Trials / Conditions / Total Knee Arthroplasty

Total Knee Arthroplasty

345 registered clinical trials studyying Total Knee Arthroplasty — 70 currently recruiting.

Status	Trial	Sponsor	Phase
Not Yet Recruiting	Utilization of a 3D Printed Mechanical Balancer During Total Knee Arthroplasty (TKA) NCT06654661	NYU Langone Health	N/A
Not Yet Recruiting	Oral Tranexamic Acid After Total Knee Arthroplasty NCT06894719	Rush University Medical Center	Phase 4
Not Yet Recruiting	A RCT Using Methadone in the Management of Post-Operative Pain in Total Knee Replacement NCT07485803	AdventHealth	Phase 4
Not Yet Recruiting	Local Infiltration Analgesia Versus Quadruple Nerve Blocks in Total Knee Arthroplasty. NCT07477730	CMC Ambroise Paré	N/A
Not Yet Recruiting	Adductor Canal Block Methods in Bilateral Total Knee Arthroplasty NCT07506629	Yonsei University	N/A
Recruiting	Femoral Triangle Block vs Adductor Canal Block on Early Quadriceps Function After Total Knee Arthroplasty NCT07524387	Social Medical Corporation Daiyukai	N/A
Not Yet Recruiting	Binaural Beats for Postoperative Pain and Anxiety Reduction NCT07437469	University of Miami	N/A
Not Yet Recruiting	Oral vs Intravenous Dexamethasone in Total Knee Arthroplasty NCT07442812	Haseki Training and Research Hospital	—
Not Yet Recruiting	AI-based Rehabilitation for Hip and Knee Surgery Patients NCT07505628	Gangnam Severance Hospital	N/A
Recruiting	REST-Knee: A Pilot RCT of 72-Hour Knee Immobilization and Pain Outcomes NCT07511842	Université de Sherbrooke	N/A
Not Yet Recruiting	The Effects of Dual-Task Exercises on Parameters After Total Knee Arthroplasty NCT07416877	Yuzuncu Yil University	N/A
Recruiting	Methylene Blue in Total Knee Arthroplasty (TKA) NCT07324954	University of Miami	Phase 1
Not Yet Recruiting	Infiltration or Nerve Blocks in Addition to Adductor Canal Block NCT06920186	GCS Ramsay Santé pour l'Enseignement et la Recherche	N/A
Not Yet Recruiting	Risk of Serious Adverse Events Following Unsupervised vs Supervised Rehabilitation After Knee Arthroplasty NCT07067060	Copenhagen University Hospital, Hvidovre	—
Recruiting	ERAS-Based Preoperative Nutrition and Fasting in Total Knee Arthroplasty NCT07336160	Nermin Ocaktan	N/A
Not Yet Recruiting	Impact of ABC-X Model Nursing on Psychological Resilience and Family Function in TKA Patients NCT07335809	The Fourth Affiliated Hospital of Zhejiang University School of Medicine	—
Not Yet Recruiting	Postoperative Analgesic Efficacy Between Adductor Canal Block + IPACK Block and Adductor Canal Block + Genicul NCT07324486	Konya Beyhekim Training and Research Hospital	N/A
Recruiting	Minimal Sedation During Knee Replacement Surgery NCT07371390	Mayo Clinic	N/A
Completed	The Effect of Quadriceps Sets Exercise on Knee Joint Biomechanics and Functional Outcomes of Post-Total Knee A NCT07233005	Cairo University	N/A
Recruiting	Effect of iPACK and BiFeS Blocks on Quality of Recovery After Total Knee Arthroplasty NCT07248072	Ataturk University	N/A
Recruiting	Supplementary Nerve Blocks Added to the Adductor Canal Block for Postoperative Pain Management in Primary Tota NCT07242170	Erzincan University	N/A
Not Yet Recruiting	Biological Link Between Anxiety and Outcomes Post Knee Arthroplasty NCT07102563	Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust	—
Recruiting	Mako Cementless TKA vs Mako Cemented TKA NCT06929871	University College, London	N/A
Recruiting	Analgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthrop NCT06740214	The University of Hong Kong	Phase 3
Not Yet Recruiting	IMProving Outcomes With ACT After Knee Surgery NCT06483191	Belfast Health and Social Care Trust	N/A
Not Yet Recruiting	Virtual Reality During Passive Motion After Knee Surgery NCT07177573	Celal Bayar University	N/A
Recruiting	Investigating Patient Satisfaction With Smart Knee Implants NCT06968143	University of Chicago	N/A
Completed	Ntelligently Integrated Digital Rehabilitation Model Combining mHealth and ERAS in Total Hip and Knee Arthropl NCT07199478	The Affiliated Hospital Of Southwest Medical University	N/A
Completed	Frontal QRS Axis Changes in Patients Undergoing Total Knee Arthroplasty With Spinal Anesthesia (FQRS-TKA) NCT07112313	Sevim Şenol Karataş	—
Recruiting	Study on BT-114143 Reducing Perioperative Bleeding in Total Knee Arthroplasty（TKA） NCT07127042	ScinnoHub Pharmaceutical Co., Ltd.	Phase 2
Recruiting	Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery NCT06946368	The Cleveland Clinic	N/A
Not Yet Recruiting	Patients' Experiences of Information After Total Knee Arthroplasty - A Qualitative Interview Study NCT06994884	Vastra Gotaland Region	—
Recruiting	Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery NCT07020312	Rush University Medical Center	Phase 2
Recruiting	Regional Anesthesia in TKA: Impact on Postoperative Joint Motion and Patient Satisfaction NCT07124494	Konya City Hospital	N/A
Recruiting	Comparison of Two Different Regional Anesthetic Methods in Total Knee Arthroplasty Patients NCT07092982	SB Istanbul Education and Research Hospital	N/A
Completed	Hemoglobin Drop and Need for Blood Transfusion in Primary Knee Arthroplasty With or Without Drain Insertion NCT07494708	Shifa International Hospital	N/A
Recruiting	Vibration Applications After Total Knee Arthroplasty in Osteopenic Women NCT06988033	Istinye University	N/A
Recruiting	Dual Subsartorial Versus Adductor Canal Block Versus Femoral Nerve Block for Postoperative Analgesia in Patien NCT07082374	Tanta University	N/A
Enrolling By Invitation	Patient-navigation-based Preoperative Rehabilitation Exercise Program in Patients Undergoing TKA NCT07047079	Anna Sun	N/A
Active Not Recruiting	The Effect of Benson's Relaxation Exercise on Anxiety and Kinesiophobia in Patients With Total Knee Arthroplas NCT07035496	Satı Danacı	N/A
Recruiting	The Benefits Of Cryoablation In Patients Undergoing Total Knee Arthroplasty NCT06991231	NYU Langone Health	N/A
Enrolling By Invitation	Infection-related Revision Rates After Single-dose Versus Multiple-dose Antibiotic Prophylaxis in Primary Hip NCT07053943	JointResearch	—
Not Yet Recruiting	Robotic-Assisted Total Knee Arthroplasty: Cruciate-Retaining Versus Bi-Cruciate Stabilized NCT06838663	Chinese University of Hong Kong	N/A
Completed	Rebound Pain After Peripheral Nerve Blocks in Total Knee Arthroplasty NCT06966011	Konya City Hospital	—
Completed	Heart Rate Variability as a Predictor of Rebound Pain Following Total Knee Arthroplasty NCT06977191	Konya City Hospital	—
Recruiting	Intraosseous (IO) Cefazolin and Vancomycin in Primary Total Knee Arthroplasty (TKA) NCT06640491	The Methodist Hospital Research Institute	Phase 1 / Phase 2
Recruiting	Implementation of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty NCT06953375	University of Colorado, Denver	N/A
Not Yet Recruiting	Gait in Fixed Or Rotating Cementless Total Knee Arthroplasties NCT06483178	Belfast Health and Social Care Trust	N/A
Completed	Effect of Hemovac Drain Removal on Early Outcomes After Total Knee Arthroplasty NCT07342894	Ankara City Hospital Bilkent	—
Completed	The Effect of Tele-Health Application on Functional Status, Self-Care Ability and Activities of Daily Living i NCT07380724	Sakarya Applied Sciences University	N/A
Completed	Effects of 10 Versus 20 mL Local Anesthetic for Popliteal Plexus Block on Opioid Consumption, Pain, and Patien NCT06908837	Regionshospitalet Silkeborg	Phase 4
Enrolling By Invitation	Intra-Articular Catheter Total Knee Arthroplasty NCT06580899	OrthoCarolina Research Institute, Inc.	Phase 4
Recruiting	Kinematic and Mechanical Alignment Randomized Trial NCT06787417	McMaster University	Phase 4
Recruiting	Combined Intrathecal Dexmedetomidine and Adductor Canal Block for Analgesia After Total Knee Arthroplasty NCT06837844	Kafrelsheikh University	N/A
Recruiting	Simulation-Based Preoperative Education in Total Knee Arthroplasty NCT07310303	Nermin Ocaktan	N/A
Completed	Distraction Techniques for Postoperative Pain After Total Knee Arthroplasty: A Randomized Controlled Trial NCT07375472	Izmir Tinaztepe University	N/A
Withdrawn	Gut Microbiome in Orthopaedics NCT06371950	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	N/A
Recruiting	Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplast NCT06083480	Vanderbilt University Medical Center	Phase 4
Withdrawn	A Prospective Clinical Study Evaluating the Newton™ TKA Protocol NCT06678750	Newton-Wellesley Hospital	N/A
Recruiting	Can the Use of Virtual Reality Improve TKA Outcomes NCT06962046	Belfast Health and Social Care Trust	N/A
Completed	Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Total Knee Arthroplasty NCT06753448	Ankara Etlik City Hospital	—
Completed	Interventional Study Exploring the Occurrence of Surgical Site Infections. NCT06661473	Molnlycke Health Care AB	N/A
Recruiting	Observation of Wheeled Device Use After TKA NCT06080152	Stanford University	N/A
Recruiting	Impact of Different Perioperative Tourniquets on Blood Loss and Surgeon Satisfaction in Total Knee Arthroplast NCT06947655	University Hospital, Bonn	N/A
Recruiting	Analgesic Efficacy of Preemptive Stepwise Infiltration Anesthesia for Perioperative Analgesia After TKA NCT06600815	First Affiliated Hospital of Fujian Medical University	N/A
Completed	NEUROCUPLE™ in TKA Patients to Enhance Pain Management NCT06460350	nCap Medical	N/A
Recruiting	Multimodal Biopsychosocial Teleprehabilitation for Total Knee Arthroplasty NCT06565377	Universitair Ziekenhuis Brussel	N/A
Recruiting	Effect of Different Cold Therapy Programs in Patients Received Total Knee Arthroplasty Operation NCT07021287	The Fourth Affiliated Hospital of Zhejiang University School of Medicine	N/A
Active Not Recruiting	Comparing Temperature in Burr vs Saw Cutting for Knee Arthroplasty NCT07010809	East Suffolk and North Essex NHS Foundation Trust	—
Recruiting	A Prospective, Randomized Parallel Group Study of the Efficacy of Vancomycin Administered Through Intraarticul NCT07282782	University of California, San Diego	Phase 4
Completed	Effect of Preoperative Cold Therapy on Early Postoperative Outcomes in Total Knee Arthroplasty NCT07134283	Ankara City Hospital Bilkent	N/A
Not Yet Recruiting	In Vivo Kinematics for Subjects Having a MicroPort Medial Pivot or DePuy Attune PCR TKA NCT04103502	The University of Tennessee, Knoxville	—
Enrolling By Invitation	Return to Activity After Total Knee Arthroplasty NCT07006545	University Hospital, Bonn	—
Recruiting	Comparing Efficiency of Mirogabalin and Pregabalin in Primary TKA NCT06328062	Thammasat University Hospital	N/A
Enrolling By Invitation	The Use of Smart Glasses for Saphenous Nerve Adductor Canal Block NCT07213622	MetroHealth Medical Center	N/A
Not Yet Recruiting	Open and Closed Platform Robotic-assisted Versus Conventional Total Knee Arthroplasty NCT06305065	Chinese University of Hong Kong	N/A
Enrolling By Invitation	Persona IQ Cohort Study NCT06089291	Zimmer Biomet	—
Completed	A Post-Market, Retrospective Study on 3D Metal Tibial and Femoral Cones NCT06578897	Medacta International SA	—
Recruiting	Performance and Safety Evaluation of the FHK®-CK Knee Prosthesis NCT06124482	FH ORTHO	N/A
Unknown	The Medially Pedicled IPFP ﬂap in TKA NCT06704776	First Affiliated Hospital of Fujian Medical University	N/A
Completed	Fall Prevention in Total Knee Replacement Patients NCT06977529	University of Gaziantep	N/A
Unknown	Oral Fluid vs IV Fluid After Primary TKA NCT06288815	Thammasat University Hospital	N/A
Withdrawn	Clinical Evaluation of the Next Science SurgX Antimicrobial Wound Gel Impact on Surgical Site Complications NCT05517278	Northwell Health	N/A
Active Not Recruiting	Polyethylene Wear Particle Analysis of TKA NCT06426641	Osaka Metropolitan University	—
Completed	The Effect of Sedation on Rebound Pain in Knee Arthroplasty NCT06555458	Ankara City Hospital Bilkent	N/A
Unknown	Continuous Adductor Canal Block in Fast Track Total Knee Arthroplasty NCT05962970	Samuel Lunenfeld Research Institute, Mount Sinai Hospital	N/A
Completed	Comparison of Modified Post-Anesthetic Discharge Scoring System (PADSS) Between 6 and 24 Hours in Patients Und NCT06233435	Thammasat University Hospital	N/A
Unknown	Muscles Strength and Gait Parameteres After TKA NCT06061367	Medical University of Warsaw	—
Recruiting	Persona MC vs PS RCT With ROSA NCT05391828	NYU Langone Health	N/A
Unknown	Feasibility Study of Peripheral Venous Cannulation Pain in Predicting Acute Pain After Total Knee Arthroplasty NCT06002724	RenJi Hospital	—
Completed	Effectiveness of Telerehabilitation in Total Knee Arthroplasty NCT06101355	Hacettepe University	N/A
Active Not Recruiting	Incidence of Adductor Canal Catheter Dislodgment NCT05961085	Sunnybrook Health Sciences Centre	—
Completed	Subvastus vs. Medial Parapatellar Approaches in Total Knee Arthroplasty With Quadriceps Muscle Elastography NCT06297746	Istanbul University - Cerrahpasa	N/A
Unknown	Accelerated Recovery for Total Knee Replacement Surgery With Preoperative Intravenous Iron Combined With Human NCT05911438	West China Hospital	N/A
Recruiting	Enhanced Recovery After Major Surgery and Chronic Pain for Total Knee Arthroplasty NCT05981105	Hospital for Special Surgery, New York	N/A
Completed	Low-Load Blood Flow Restriction Training With Patients Who Underwent a Total Knee Arthroplasty: a Feasibility NCT05843773	HES-SO Valais-Wallis	N/A
Completed	Effection of Total Knee Arthroplasty on Knee Joint NCT05965765	KTO Karatay University	N/A
Completed	Correlation Between Preoperative Knee Extension Lag and Functional Outcome After Total Knee Arthroplasty NCT05833152	Peking University Third Hospital	—
Active Not Recruiting	Surgery Induced Trauma After Total Versus Medial Unicompartmental Knee Arthroplasty (SITA) NCT05735847	Hvidovre University Hospital	—
Completed	Ultrasound-Guided PASC Block vs Femoral-Sciatic Nerve Block for Postoperative Analgesia After Total Knee Arthr NCT07320833	Ain Shams University	N/A
Completed	Reinfection and Re-revision Rates of Periprosthetic Knee Infection Under Four Different Surgical Strategies NCT07232771	First Affiliated Hospital of Fujian Medical University	—
Unknown	Effect of Postoperative Oral Carbohydrate Administration in Total Knee Arthroplasty Elderly Patients NCT05603364	Nanjing First Hospital, Nanjing Medical University	EARLY_Phase 1
Active Not Recruiting	ALknee Follow-up Study of the Cementless ATTUNE Rotating Platform and the Cementless LCS Rotating Platform Kne NCT05623215	Spaarne Gasthuis	—
Terminated	Medial Peel Release Technique TKA Randomized Clinical Trial NCT05154058	Emory University	N/A
Completed	Assessing Function and Pain After Total Knee Arthroplasty With Combined Femoral and Popliteal Nerve Block NCT06196359	University of Haifa	N/A
Completed	Early Radiographic and Clinical Outcomes of Robotic-Arm-Assisted Versus Conventional TKA NCT05987839	Peking University Third Hospital	N/A
Completed	Joint Movement to Increase Range of Motion in Knee Joint After Primary Total Knee Arthroplasty NCT06188091	Nordsjaellands Hospital	N/A
Unknown	Phase Ⅱ Study of Adductor Canal Block With HR18034 for Postsurgical Pain Management NCT05561309	Shanghai Hengrui Pharmaceutical Co., Ltd.	Phase 2
Unknown	Clinical and Functional Outcomes of Tourniquet Use in Primary Total Knee Arthroplasty NCT05581563	Mongi Slim Hospital	N/A
Completed	Analgesic Effect of Adductor Canal Block, IPACK Block, and Genicular Nerve Block NCT06686095	Hitit University	N/A
Completed	Trial of Liposomal Bupivacaine for TKA NCT05635916	Northern Light Mercy Hospital	Phase 4
Completed	Perineural Dexamethasone for Continuous Femoral Nerve Block NCT05487001	Gangnam Severance Hospital	N/A
Active Not Recruiting	NitrX Total Knee Arthroplasty RSA NCT05151315	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	N/A
Completed	Acute Effects of Strengthening Lower Limbs Operated by Total Knee Arthroplasty NCT05444400	University of Valencia	N/A
Unknown	Single-injection Modified 4 in 1 Block as Postoperative Analgesia in Total Knee Arthroplasty NCT05447871	Mansoura University	N/A
Completed	Evaluating the Feasibility and Effectiveness of Using a Smartphone Application During Rehabilitation in Patien NCT05434767	Singapore General Hospital	N/A
Recruiting	Multigen Plus CCK and AMF TT Cones Follow Up Study NCT05314491	Limacorporate S.p.a	—
Completed	Remimazolam Total Intravenous Anesthesia Under Analgesia Nociception Index-guidance NCT05322902	Gangnam Severance Hospital	N/A
Completed	Ultrasound-Guided Popliteal Plexus Block Versus Fascia Iliaca Block After Total Knee Arthroplasty NCT05390450	Tanta University	N/A
Recruiting	Evaluation of Two Surgical Strategies for Robotic Implantation of Total Knee Prostheses (Stryker), Cemented Ve NCT04692714	Hospices Civils de Lyon	N/A
Recruiting	Clinical Utility and Gait Analysis of NextAR System AUS NCT05863741	Medacta International SA	—
Unknown	The Ultrasonographic Measurement of Quadriceps Muscle Thickness and the Shape of the Femoral Nerve in Patients NCT05382507	Yonsei University	—
Completed	Efficacy of Combined Adductor and Tibial Nerve Blocks for Pain Management in Knee Arthroplasty NCT06552897	Ankara City Hospital Bilkent	N/A
Recruiting	Intraoperative VR for Older Patients Undergoing TKA NCT04748549	Beth Israel Deaconess Medical Center	N/A
Recruiting	Improving Rehabilitation for Veterans After Total Knee Arthroplasty Using Individualized Recovery Trajectories NCT05288803	VA Office of Research and Development	—
Completed	Early Clinical Benefits of Robot-Assisted vs Manual Total Knee Arthroplasty (RATKA-EARLY) NCT07078149	Hospital Universitario Santa Cristina	N/A
Completed	Periarticular Bupivacaine + Meloxicam ER Solution Versus Standard Practice During Total Knee Arthroplasty NCT05188053	Mayo Clinic	Phase 4
Unknown	Personalized Information Before and After Total Knee Arthroplasty: PAK-study NCT05266482	Kliniek ViaSana	N/A
Completed	Effect of Emotional Freedom Technique on Postoperative Pain and Anxiety in Patients Undergoing Total Knee Repl NCT05541666	Ataturk University	N/A
Terminated	Medrol Dosepak Taper for Delayed Post-op Recovery After TKA NCT05113901	Rush University Medical Center	Phase 4
Recruiting	Medrol Dosepak for Outpatient Total Knee Arthroplasty NCT05097976	Rush University Medical Center	Phase 4
Unknown	Graded Motor Imagery and Total Knee Arthroplasty NCT05138406	Inonu University	N/A
Completed	GENIFEM Trial: Postoperative Pain After Total Knee Arthroplasty (TKA) NCT05156476	Ziekenhuis Oost-Limburg	Phase 3
Unknown	Comparison Between Brainlab Knee 3 Computer-assisted Navigation Systems and Conventional Instruments in TKA: a NCT04960345	Peking University Third Hospital	—
Completed	Dexamethasone and Functional Outcome After TKA NCT05137080	Slagelse Hospital	Phase 4
Unknown	Esketamine vs. Ketorolac for Prevention of Postoperative Pain and Cognitive Dysfunction After Total Knee Arthr NCT05132595	Tianjin Medical University General Hospital	N/A
Completed	The Effect of Preoperative Active Warming on Intraoperative Body Temperature NCT05334589	Burdur Mehmet Akif Ersoy University	N/A
Completed	Duloxetine RCT on Postop TKA Outcomes NCT05086393	Rush University Medical Center	Phase 4
Completed	Dexamethasone in Total Knee Arthroplasty NCT05018091	Rush University Medical Center	Phase 4
Unknown	Efficiency Assessment of the Methodology for the Follow-up of Patients With Knee Prostheses NCT04850300	University of Valencia	Phase 3
Completed	Genicular Nerve Radiofrequency Ablation for Chronic Knee Pain After Total Knee Arthroplasty NCT05130216	University of Utah	—
Withdrawn	Using Peripheral Nerve Stimulation (PNS) to Treat Chronic Post-surgical Pain (CPSP) After Knee Surgery NCT04670042	Stanford University	N/A
Recruiting	Prediction of Postoperative Outcomes After TKA Using Instrumented Insoles and DNN NCT07367789	Yonsei University	—
Unknown	Journey 2 Multi Center Kinematic Study NCT05107414	The University of Tennessee, Knoxville	—
Completed	Comparison Of Outcomes After Knee Arthroplasty Using Posterior-Substituting Versus Cruciate-Retaining Prosthes NCT06170931	Bezmialem Vakif University	N/A
Completed	Swelling Management After Total Knee Arthroplasty NCT04841356	University of Colorado, Denver	N/A
Unknown	Study on Fear of Movement After Total Knee Arthroplasty NCT04963361	Peking University Third Hospital	—
Completed	Dronabinol in Total Knee Arthroplasty (TKA) NCT04734080	Hospital for Special Surgery, New York	Phase 4
Completed	Outcomes for Manual Lymphatic Drainage NCT04795011	Selcuk University	N/A
Completed	Systemic Lidocaine Versus Ultrasound-guided Adductor Canal Block for Patients Undergoing Total Knee Arthroplas NCT04828083	Rhode Island Hospital	Phase 4
Completed	Manual Lymphatic Drainage Before and After Total Knee Replacement, a Single-center Observer-blinded Randomized NCT05119764	Moritz Wagner	N/A
Suspended	PMCF Study of MPS-Flex® Knee System in TKA NCT04427722	Zimmer Biomet	—
Withdrawn	BFRT vs Standard PT After Total Knee Arthroplasty NCT04366336	Norton Healthcare	N/A
Suspended	How Muscle and Tendon Properties Contribute to Functional Change Prior to and Following Knee Replacement NCT04740073	University of British Columbia	—
Completed	Reliability, Concurrent Validity and Minimal Detectable Change of the Step Up and Down Test in Patients With T NCT06344182	Dokuz Eylul University	—
Withdrawn	Impact of Crutch Type on Gait and Functional Outcomes Post-knee Surgery NCT04258917	University of Calgary	N/A
Unknown	Comparison of Opioid and Duloxetine for Postoperative Pain Control After Total Knee Arthroplasty: RCT NCT04719585	The Catholic University of Korea	N/A
Completed	Peri-Articular-Multimodal Drug and Oral Celecoxib in Management of Postoperative Pain of Total Knee Arthroplas NCT05324995	Isfahan University of Medical Sciences	Phase 2
Completed	Postoperative Painful Chronicization After Knee Replacement Surgery : Exploratory Study of BDNF's Kinetics NCT04604847	University Hospital, Montpellier	N/A
Completed	Dexmedetomidine as an Adjuvant for Femoral Nerve Block and Functional Recovery After Total Knee Arthroplasty NCT04642651	Peking University First Hospital	Phase 4
Completed	RCT Foley Catheter Study for Elective TJA NCT05428020	Rush University Medical Center	N/A
Unknown	Comparison of TKAs Using Force Plate Analysis NCT04163445	Russell Nevins, M.D.	N/A
Completed	In Vivo Kinematics for Subjects With Smith & Nephew Journey II BCS TKA, Journey II CR TKA, Or Journey II XR TK NCT04612036	The University of Tennessee, Knoxville	—
Unknown	A Study to Evaluate the Outcomes of Cannabinoid (CBD) Roll-on Topical Stick in Primary Total Knee Arthroplasty NCT04585230	Rothman Institute Orthopaedics	N/A
Completed	Treatment of Post-Operative Pain Following Orthopedic Surgery With SPRINT® Peripheral Nerve Stimulation (PNS) NCT04341948	SPR Therapeutics, Inc.	N/A
Terminated	Observational Study to Evaluate Clinical Performance and Safety in Total Knee Arthroplasty NCT04872855	Corin	—
Unknown	Comparison of Surgical Glove Contamination During Total Knee Arthroplasty Procedure : a Randomized Controlled NCT04308798	Khon Kaen University	Phase 3
Unknown	Efficiency of Donepezil in Elderly Patients for Prevention of POCD Dysfunction NCT04423276	RenJi Hospital	Phase 4
Unknown	Adductor Canal Block in Outpatient Clinic for Pain Control After Knee Arthroplasty NCT04883034	Gadjah Mada University	N/A
Completed	Single-injection Adductor Canal Block for Total Knee Arthroplasty Under Spinal Anesthesia NCT04400708	Seoul National University Hospital	N/A
Unknown	Cemented vs Cementless in Bilateral TKA NCT04496102	Thammasat University	N/A
Completed	Analysis of Competitive Posterior Cruciate Retaining (PCR) and Posterior Stabilized (PS) Total Knee Arthroplas NCT04321356	The University of Tennessee, Knoxville	—
Recruiting	GMK Sphere TiNb Total Knee Arthroplasty PMS Study NCT04801654	Medacta International SA	—
Completed	Effects of Anesthesia Type on Inflammatory Response NCT06984315	Tokat Gaziosmanpasa University	—
Completed	Is Self-transfusion Safe After Total Knee Arthroplasty in Terms of Nephrotoxicity of Gentamicin From Bone Ceme NCT04505748	University Hospital, Alexandroupolis	N/A
Completed	Efficacy of NSAID and Acetaminophen in the Control of Post-Operative Pain in Patients Undergoing Total Knee Re NCT05393414	University of Puerto Rico	N/A
Completed	Combined NMES and BFR Training After TKA NCT04347343	University of Colorado, Denver	N/A
Unknown	Effect of Fast Inpatient Rehabilitation After TKA NCT04458480	Peking University Third Hospital	—
Completed	Comparison of the Supervised and Home-Based Progressive Resistant Training in Female Total Knee Arthroplasty P NCT05618015	Pamukkale University	N/A
Completed	Value of Continuous Passive Motion in Rehabilitation After Total Knee Replacement NCT06381752	Johannes Gutenberg University Mainz	N/A
Completed	MAKv1 Exoskeleton for TKA Patients: a Safety, Usability and Clinical Effects Trial of an Early Intervention NCT05544409	MarsiBionics	N/A
Active Not Recruiting	Safety and Performance Study of the Legion Porous System in Total Knee Arthroplasty NCT03720782	Smith & Nephew, Inc.	—
Completed	Tow Techniques of Adductor Canal Block for Analgesia After Total Knee Replacement NCT03942133	Peking Union Medical College Hospital	N/A
Unknown	Visual Field Infiltration of Tranexamic Acid Reduced the Blood Loss in Total Knee Arthroplasty NCT03934047	Second Affiliated Hospital, School of Medicine, Zhejiang University	N/A
Completed	Trial Comparing a Multi-Modal Pain Protocol With and Without Opioids Following Total Joint Arthroplasty NCT03845881	Mayo Clinic	EARLY_Phase 1
Terminated	Is There an Alternative to Immediate Home Physical Therapy Following Total Knee Arthroplasty NCT04060251	Wolfgang Fitz, M.D.	N/A
Completed	Exercise Device in Total Knee Arthroplasty NCT03876431	Istanbul University	N/A
Terminated	Compressive Stockings Therapy After TKA NCT04434222	Balgrist University Hospital	N/A
Unknown	The Efficacy of Using CR and PS Prosthesis in Total Knee Replacement NCT03877042	Xijing Hospital	N/A
Completed	The Relationship Between Preoperative Serum Cytokine Level and Lenght of Stay in Hospital, Postoperative Pain NCT04487535	Hacettepe University	N/A
Completed	Intraoperative Direct vs Postoperative Ultrasound Guided Adductor Canal Nerve Block After Total Knee Arthropla NCT03733509	Pontificia Universidad Catolica de Chile	N/A
Completed	Effectiveness of a Community-based Multi-modal Tai Chi Rehabilitation Program for Patients After Total Knee Ar NCT03565380	The Hong Kong Polytechnic University	N/A
Completed	Comparison of Analgesic Efficiency Between IPACK Block and Surgical Infiltration After Total Knee Arthroplasty NCT03704831	University Hospital, Montpellier	—
Unknown	IPACK Block in Total Knee Arthroplasty NCT03692858	Asklepieion Voulas General Hospital	Phase 2
Completed	In Vivo Kinematics for Subjects Implanted With Klassic Total Knee Arthroplasty (TKA) NCT04113785	The University of Tennessee, Knoxville	—
Completed	Femoral Triangle and Adductor Canal Blocks Versus Femoral Nerve Block for Total Knee Arthroplasty NCT03645954	Lithuanian University of Health Sciences	N/A
Active Not Recruiting	Safety and Performance Using Legion™ CR Oxinium and CoCr Femoral Implants Combined With Legion™/Genesis™ II XL NCT03687593	Smith & Nephew, Inc.	—
Completed	Comparing Surgical and Economical Parameters of Total Knee Replacement. NCT03427047	Medacta USA	N/A
Unknown	Using a Smartphone App to Aid in Functional Mobility Return Following Total Knee Arthroplasty NCT03607461	Lagniappe Physical Therapy	N/A
Unknown	Effect of Preoperative Ferric Carboxymaltose After Simultaneous Bilateral Total Knee Arthroplasty NCT03561506	The Catholic University of Korea	Phase 4
Unknown	Effect of Postoperative Ferric Carboxymaltose NCT03561480	The Catholic University of Korea	Phase 4
Completed	The Effect of the Educational Plan Prepared According to the Health Literacy Levels of Patients NCT05088551	Bozok University	N/A
Unknown	Adductor Canal Block in an Enhanced Recovery Program After Total Knee Arthroplasty NCT03915522	Institut de Recerca Biomèdica de Lleida	N/A
Unknown	Total Knee Arthroplasty Robot Assisted With MAKO™ Robotic System Compared to the Conventional Total Knee Arthr NCT03566875	University Hospital, Grenoble	N/A
Unknown	Analgesic Efficacy of Adding SCB With Low Concentration Bupivacaine Combined With Dexamethasone on Pain After NCT03486548	Mahidol University	Phase 4
Withdrawn	Obstructive Sleep Apnea in Elective Orthopaedic Surgery NCT03166462	University of Miami	N/A
Completed	Movement Pattern Biofeedback Training After Total Knee Arthroplasty NCT03325062	University of Colorado, Denver	N/A
Unknown	Activity Trackers for Monitoring During Rehabilitation After Total Knee Arthroplasty NCT03368287	Peking University People's Hospital	N/A
Completed	Patients' Views on Outcomes Following Total Knee Arthroplasty: a Focus-group Study NCT03064334	University of Salford	—
Unknown	Pulsed Shortwave Therapy Adjunct Pain and Recovery in Total Knee Replacement NCT03395444	BioElectronics Corporation	N/A
Completed	Lymphodreinage Integrated With Kinesio Tape in TKA Patients NCT03452995	Istituto Ortopedico Rizzoli	N/A
Completed	Optimizing Physical Activity Outcomes After Total Knee Arthroplasty NCT03226106	VA Office of Research and Development	N/A
Completed	Navio With Total Knee Arthroplasty NCT03317834	Smith & Nephew, Inc.	—
Completed	Treatment With Iovera° for Total Knee Arthroplasty (TKA) Post-Operative Pain NCT03327220	Pacira Pharmaceuticals, Inc	N/A
Completed	Analysis of Patient Outcome Questionnaire Following Primary Knee Replacement NCT03132077	University of Salford	—
Terminated	US Guided GNB vs Saline Injection for TKA NCT03316118	Northwestern University	Phase 4
Completed	Electrical Stimulation for the Treatment of Pain Following Total Knee Arthroplasty Using the SPRINT Beta Syste NCT03286543	SPR Therapeutics, Inc.	N/A
Unknown	Tourniquet Application on Total Knee Arthroplasty NCT03256058	The Affiliated Hospital of Xuzhou Medical University	N/A
Completed	The Health Impact of Mindfulness Based Stress Reduction on Total Knee Arthroplasty NCT03228745	University of Manitoba	N/A
Completed	The Effect of Popliteal Plexus Block on Pain After Total Knee Arthroplasty NCT03198403	Regionshospitalet Silkeborg	Phase 4
Unknown	Forgotten Joint Score After Reversed Gap Technique NCT03044457	University of Jena	N/A
Completed	Using Mobilization Exercises on Total Knee Arthroplasty Rehabilitation NCT03215160	Istanbul University	N/A
Unknown	Enhanced Recovery After Surgery for Total Knee Arthroplasty, Left Colectomy and Hysterectomy NCT03552913	Assistance Publique - Hôpitaux de Paris	—
Completed	Epidural Morphine for Postoperative Analgesia After Total Knee Arthroplasty NCT03203967	Peking University First Hospital	N/A
Active Not Recruiting	A Study Using Metaphyseal Cones Versus a Cemented Stem Construct in Revision TKR NCT03169634	Royal Devon and Exeter NHS Foundation Trust	N/A
Completed	A PROMs Based Educational Tool (PROM-DA) for Patients Considering Total Knee Arthroplasty NCT03240913	University of Calgary	N/A
Completed	Adductor Canal Block Versus Liposomal Bupivacaine in TKA NCT04086186	Good Samaritan Regional Medical Center, Oregon	Phase 4
Completed	An Exploration of Outcomes Post-total Knee Arthroplasty in Middle East NCT02998125	University of Salford	—
Terminated	Study to Evaluate Long Term Performance and Safety of the Knee Prosthesis (HLS KneeTec Deep Dish) NCT05211141	Corin	—
Completed	Effect of Music in Intraoperative Period NCT04485650	Abant Izzet Baysal University	N/A
Completed	Single Injection Adductor Canal Block Versus Continuous Adductor Canal Infusion for Total Knee Arthroplasty NCT02991404	Wake Forest University Health Sciences	EARLY_Phase 1
Completed	Conventional vs. Sensor Guided Soft Tissue Balancing in TKA RCT NCT02976428	Hamilton Health Sciences Corporation	N/A
Unknown	Measuring Every Day (MED) Study NCT03010605	The Christ Hospital	N/A
Completed	Journey II Bi-Cruciate Stabilized (BCS) Total Knee System Retrospective Study NCT03292003	Smith & Nephew, Inc.	—
Terminated	Study of Local Administration of DepoTXA for Reduced Postsurgical Bleeding in Subjects Undergoing TKA NCT02922582	Pacira Pharmaceuticals, Inc	Phase 2
Withdrawn	Single Versus Multi-Dose Oral Tranexamic Acid in Patients at High Risk for Blood Transfusion After Total Joint NCT02926651	Rush University Medical Center	Phase 4
Completed	Effect of Preoperative Exercise in Patients Undergoing Total Knee Arthroplasty NCT03160534	Balgrist University Hospital	N/A
Completed	Ultrasound-guided Continuous Adductor Canal Block for Analgesia After Total Knee Replacement: Comparison of Sh NCT02799797	Cui Xulei	N/A
Completed	Single Injection Adductor Canal Block vs Catheter for Total Knee Arthroplasty NCT02798835	University of British Columbia	Phase 4
Unknown	Blood Flow Restriction Training Following Total Knee Arthroplasty NCT02763488	San Antonio Military Medical Center	N/A
Completed	Total Knee Arthroplasty Combined With Psychological Intervention for Patients With Psychological Disorders NCT03715608	Peking University Third Hospital	N/A
Unknown	Dexamethasone in Total Knee and Total Hip Arthroplasty NCT02760043	University Health Network, Toronto	Phase 2 / Phase 3
Completed	interACTION: A Portable Joint Function Monitoring and Training System for Remote Rehabilitation Following TKA NCT02646761	James J. Irrgang	N/A
Completed	Total Knee Arthroplasty With and Without Tourniquet: Comparative Study NCT04130009	Hawler Medical University	N/A
Completed	Improved Pain Management in Knee Osteoarthritis-related Surgeries NCT06124170	Peng Liu	—
Unknown	The Effect of Continuous Femoral Nerve Block With Modulation of Depth of Anesthesia on Prognosis of Patients R NCT02576015	Min Su	N/A
Completed	Antero-Posterior Knee Stability NCT03387839	David F. Scott, MD	—
Completed	Kinematic Analysis: Posterior Stabilized, Fixed Bearing Total Knee Arthroplasty With Attune Knee System - Phas NCT02613338	The University of Tennessee, Knoxville	—
Completed	Single Shot vs 24hr vs 48hr Continuous Adductor Canal Block After TKA NCT02730728	University of Pennsylvania	N/A
Completed	Electrical Stimulation for the Treatment of Pain Following Total Knee Arthroplasty (TKA) Using the SPRINT Syst NCT02468934	SPR Therapeutics, Inc.	N/A
Withdrawn	Peri-articular Injection Utilizing a Pain Cocktail With and Without Exparel NCT02571283	University of Louisville	Phase 4
Completed	Local Infiltration Analgesia in Total Knee Arthroplasty NCT03206554	Asklepieion Voulas General Hospital	Phase 2
Withdrawn	Ultrasound-guided Continuous Proximal Adductor Canal vs Continuous Femoral Nerve Block for Postoperative Pain NCT02495805	Yale University	N/A
Completed	Tissue Adhaesive in Wound Closure Following Primary Total Knee Arthroplasty NCT03289247	Hvidovre University Hospital	N/A
Completed	Effects of Catheter Location on Postoperative Analgesia for Continuous Adductor Canal and Popliteal-Sciatic Ne NCT02523235	University of California, San Diego	Phase 4
Completed	ATTUNE TM Video-fluoroscopy Study NCT02358434	Dr. Renate List	—
Completed	Stereo Radiography of TKA Patella Mechanics NCT02532933	University of Denver	N/A
Completed	Oral Carbohydrate in DM Patients Undergoing Total Knee Arthroplasty NCT02432781	Severance Hospital	N/A
Active Not Recruiting	Hybrid Versus Cemented TKA Using the NexGen LPS Prosthesis NCT02798432	Jesus Moreta Suarez	N/A
Withdrawn	Efficacy of Single Injection Femoral Nerve Block With Liposomal Bupivacaine for Total Knee Arthroplasty NCT01977339	St. Luke's-Roosevelt Hospital Center	Phase 4
Unknown	Continuous Femoral Nerve Block Versus Local-wound Infiltration Analgesia For Patients Receiving Total Knee Art NCT02284620	First Affiliated Hospital of Chongqing Medical University	Phase 4
Completed	Relaxation Treatment in Total Knee Arthroplasty NCT04845204	Hacettepe University	N/A
Withdrawn	Cemented Versus Uncemented Total Knee Arthroplasty : a Prospective Randomized Study NCT02355652	Hospices Civils de Lyon	Phase 4
Completed	The Effects of Manual Lymphatic Drainage and Kinesiotaping on Lower Extremity Edema NCT04164927	Hacettepe University	N/A
Terminated	Manual Lymph Drainage NCT02360735	Anne Arundel Health System Research Institute	N/A
Completed	Kinematic Analysis: Posterior Stabilized, Fixed Bearing Total Knee Arthroplasty With Attune Knee System NCT02204748	The University of Tennessee, Knoxville	—
Completed	Knee Arthroplasty Rehabilitation Outcomes Study NCT02426190	MedStar National Rehabilitation Network	N/A
Completed	Interferential Current Therapy After Total Knee Arthroplasty NCT03542981	Ege University	N/A
Completed	Predictability of the Ability to Perform an Emergency Stop NCT02175160	University Hospital Tuebingen	N/A
Completed	Peripheral Nerve Blocks vs Periarticular Local Anesthetic Injection for Total Knee Arthroplasty (TKA) NCT02223364	Mayo Clinic	Phase 4
Completed	Comprehensive Assessment of the Musculoskeletal System NCT02156011	Swiss Federal Institute of Technology	—
Unknown	Effectiveness of Intraoperative Exparel for Postoperative Pain Control in Total Knee Arthroplasty NCT02808728	DeClaire LaMacchia Orthopaedic Institute	Phase 4
Terminated	Continuous Local Anesthesia Versus Continuous Femoral Nerve Bloc After Total Knee Arthroplasty: Impact on Mean NCT02006355	University Hospital, Strasbourg, France	Phase 4
Completed	Inpatient Versus Outpatient Rehabilitation After TKA NCT02120313	University of Rostock	N/A
Completed	Adductor Canal Block and Recovery After Total Knee Replacement Surgery NCT02411149	University Health Network, Toronto	Phase 4
Withdrawn	Total Knee Prosthesis With Continuous Block of Adductor Canal and Outcome NCT02082067	ASST Gaetano Pini-CTO	Phase 4
Completed	Protracted Effect of Combined Nerve Blocks After Total Knee Arthroplasty NCT02067078	Regionshospitalet Silkeborg	Phase 4
Unknown	Comparison of Two Periarticular Injection Medications for Adjunctive Pain Management Following Total Knee Arth NCT02060591	Rothman Institute Orthopaedics	N/A
Completed	Effectiveness of Passive and Active ROM Exercises Following TKA NCT02062138	University of Rostock	N/A
Completed	Impact of Prehabilitation in Total Knee Replacement NCT01844934	Allina Health System	N/A
Completed	Can Dexmedetomidine For Procedural Sedation In Knee Arthroplasty Reduce Postoperative Pain? A Randomized Contr NCT02026141	University of Saskatchewan	Phase 4
Completed	Understanding GMK Sphere Implant Tibiofemoral Kinematics by Means of Dynamic Videofluoroscopy NCT03041857	Dr. Renate List	—
Completed	Is the STOP-BANG Predictive of Worsening OSA in the Early Postop Period in Patients Undergoing TJA? NCT02123225	United States Naval Medical Center, San Diego	—
Completed	Does Duloxetine Reduce Sub-Acute Pain After Knee Arthroplasty? NCT02005601	Hospital for Special Surgery, New York	Phase 4
Completed	Bupivacaine Liposome Suspension Versus a Concentrated Multi Drug Periarticular Injection NCT02299349	TriHealth Inc.	N/A
Completed	Perfusion Assessment of Wound Closure Techniques in Primary Total Knee Arthroplasty NCT01924403	Mayo Clinic	N/A
Completed	Return Physical Activities After Total Knee Arthroplasty NCT04746144	Cincinnati Sportsmedicine Research and Education Foundation	—
Completed	Comparison of Continuous Femoral Nerve Block and Adductor Canal Block After Total Knee Replacement Therapy NCT02125903	Philipps University Marburg	N/A
Completed	Continuous Versus Intermittent Sciatic Block for Total Knee Arthroplasty NCT01843153	Kreiskrankenhaus Dormagen	Phase 4
Completed	The Efficacy of Peripheral Nerve Blocks With Intrathecal Morphine in Improving Analgesia After Unilateral Tota NCT02135120	American University of Beirut Medical Center	N/A
Completed	Pain After Total Knee Arthroplasty: A Trial Examining Combined Adductor-canal Nerve Block and Periarticular In NCT01797588	North York General Hospital	Phase 4
Completed	The Effect of Home-based Velocity Training in Individuals With Total Knee Replacement NCT01808781	Texas Woman's University	N/A
Completed	Analgesia After Total Knee Replacement Surgery NCT01489631	St. Antonius Hospital	N/A
Completed	Periarticular Injection Versus Fascia Iliaca Block for Total Knee Arthroplasty NCT02047331	Baskent University	Phase 4
Completed	Tourniquet and Quadricepsforce NCT01808859	Region Skane	N/A
Completed	Optimizing Pain and Rehabilitation After Knee Arthroplasty NCT01616836	Sunnybrook Health Sciences Centre	Phase 3
Withdrawn	Duration of Leg Nerve Blocks With Dexamethasone Added to Local Anesthetic NCT01511211	University of New Mexico	Phase 4
Completed	Plasma Concentrations of Bupivacaine After Peri-articular Injection in Total Knee Arthroplasty NCT01636869	Mahidol University	Phase 4
Completed	The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Inj NCT01638624	Diskapi Teaching and Research Hospital	Phase 4
Terminated	Clinical Outcomes and Cost-effectiveness Analysis of ShapeMatch Technology NCT01483066	University of Alberta	Phase 4

Showing the 300 most recent trials. Use search for older records.