NCT07485803

A RCT Using Methadone in the Management of Post-Operative Pain in Total Knee Replacement

A Prospective, Randomized Trial Utilizing Methadone in the Management of Post-Operative Pain in Total Knee Replacement

• Status: Not Yet Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 192 (estimated)
• Sponsor: AdventHealth · Academic / Other
• Sex: All
• Age: 21 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The goal of this study is to determine whether one dose of IV methadone given right before surgery will help patients' pain management after a total knee replacement and reduce the amount of pain medications taken in the weeks after surgery.

Conditions

• Total Knee Arthroplasty

Interventions

Type	Name	Description
DRUG	Methadone	Subjects randomized to receive methadone will be given one dose of methadone 0.15mg/kg intravenously dosed based on ideal body weight administered by the anesthesia team prior to surgical incision

Timeline

• Start date: 2026-06-01
• Primary completion: 2028-04-01
• Completion: 2028-06-01
• First posted: 2026-03-20
• Last updated: 2026-03-20

Regulatory

• FDA-regulated drug study