NCT02005601

Does Duloxetine Reduce Sub-Acute Pain After Knee Arthroplasty?

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 106 (actual)
• Sponsor: Hospital for Special Surgery, New York · Academic / Other
• Sex: All
• Age: 25 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

We are investigating the impact of duloxetine ("Cymbalta"), a serotonin and norepinephrine reuptake inhibitor, on pain after total knee arthroplasty (TKA). Specifically, the investigators will determine whether duloxetine, 60 mg daily for 2 weeks, reduces pain scores 2 weeks after TKA.

Conditions

• Total Knee Arthroplasty

Interventions

Type	Name	Description
DRUG	Placebo	Patients will receive placebo drug with no active ingredients per dose. 1 capsule will be taken pre-operatively. One capsule once a day until end of POD14.
DRUG	Duloxetine 60mg	Patients will receive 60mg of duloxetine per dose. 1 capsule will be taken pre-operatively. One capsule once a day until end of POD14.

Timeline

• Start date: 2013-11-01
• Primary completion: 2015-05-01
• Completion: 2015-08-01
• First posted: 2013-12-09
• Last updated: 2017-08-29
• Results posted: 2017-08-29

Locations

1 site across 1 country: United States