NCT06753448

Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Total Knee Arthroplasty

Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Primary Total Knee Arthroplasty

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 190 (actual)
• Sponsor: Ankara Etlik City Hospital · Other Government
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to find out the efficacy of diosmin and hesperidin on postoperative early rehabilitation after primary total knee arthroplasty. The main questions it aims to answer are: Does diosmin and hesperidin combined drug decreases the lower extremity swelling, pain and increases the range of motion after primary total knee arthroplasty surgery compared to standard therapy group? Does diosmin and hesperidin combined drug decreases inflammation after total knee arthroplasty surgery. Participants will take diosmin and hesperidin in addition to standard therapy for 14 days after total knee arthroplasty surgery. Lower extremity swelling, pain and range of motion of the patients will be recorded in every visit.

Conditions

• Total Knee Arthroplasty
• Venous Insufficiency of Leg

Interventions

Type	Name	Description
DRUG	Diosmin and Hesperidin Combination	Participants will take diosmin and hesperidin combination for 14 days after total knee replacement surgery.

Timeline

• Start date: 2024-10-08
• Primary completion: 2025-06-10
• Completion: 2025-06-10
• First posted: 2024-12-31
• Last updated: 2025-07-15

Locations

1 site across 1 country: Turkey (Türkiye)