Trials / Completed
CompletedNCT01638624
The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Injury
The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Injury in Total Knee Arthroplasty
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 36 (actual)
- Sponsor
- Diskapi Teaching and Research Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
The release of tourniquet produces reactive oxygen species which can cause injury. Propofol is chemically similar to phenol-based free radical scavengers. Plasma total antioxidant capacity is a well-established marker of the overall protective effect of antioxidants in body fluids.The aim of the study is to investigate the effects of propofol on ischemia-reperfusion injury in total knee arthroplasty (TKA).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Propofol | Propofol :Propofol is an anesthetic agent, has structure similar to that of known such as alfa tocopherol. |
| DRUG | Placebo |
Timeline
- Start date
- 2012-06-01
- Primary completion
- 2012-10-01
- Completion
- 2012-11-01
- First posted
- 2012-07-12
- Last updated
- 2016-06-13
Locations
1 site across 1 country: Turkey (Türkiye)
Source: ClinicalTrials.gov record NCT01638624. Inclusion in this directory is not an endorsement.