NCT05487001

Perineural Dexamethasone for Continuous Femoral Nerve Block

Analgesic Effect of Dexamethasone as a Perineural Adjuvant for Continuous Femoral Nerve Block After Total Knee Arthroplasty: a Prospective Randomized Placebo-controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Gangnam Severance Hospital · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

An alternative to improve the quality of postoperative analgesia is to use various perineural adjuvants applicable to peripheral nerve block along with local anesthetics to increase the analgesic effect. Dexamethasone is a strong and long-acting corticosteroid, which reduces postoperative nausea and vomiting and increases the duration of nerve blockade. Most of the existing clinical studies compared the analgesic effect with the placebo group after adding an adjuvant in a single shot nerve block, and there were very few cases of comparing the analgesic effect with the placebo group after adding the adjuvant in peripheral nerve block through continuous catheter infusion. Therefore, we designed this study to investigate whether the use of dexamethasone as a peripheral adjuvant for continuous femoral nerve block has a better pain and recovery profile.

Conditions

• Total Knee Arthroplasty

Interventions

Type	Name	Description
PROCEDURE	dexamethasone group	1\) Arm l (dexamethasone group) Ultrasound-guided femoral nerve block with 1% lidocaine 15 ml after the end of surgery Postoperative femoral nerve patient controlled analgesia * Total volume 250 ml (0.375% ropivacaine 60 ml + normal saline 188 ml + dexamethasone 10 mg (2 ml)) * Basal rate 4 mL/hr, Bolus volume 2 mL, Lock-out time 15 min
PROCEDURE	sham group	2\) Arm ll (sham group) Ultrasound-guided femoral nerve block with 1% lidocaine 15 ml after the end of surgery Postoperative femoral nerve patient controlled analgesia * Total volume 250 ml (0.375% ropivacaine 60 ml + normal saline 190 ml * Basal rate 4 mL/hr, Bolus volume 2 mL, Lock-out time 15 min

Timeline

• Start date: 2022-08-09
• Primary completion: 2024-01-19
• Completion: 2024-01-19
• First posted: 2022-08-04
• Last updated: 2024-02-23

Locations

1 site across 1 country: South Korea