Trials / Unknown
UnknownNCT04423276
Efficiency of Donepezil in Elderly Patients for Prevention of POCD Dysfunction
Efficiency of Donepezil in Elderly Patients Undergoing Orthopedic Surgery Due to Underlying Postoperative Cognitive Dysfunction, a Multicenter Randomized Controlled Trial
- Status
- Unknown
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 360 (estimated)
- Sponsor
- RenJi Hospital · Academic / Other
- Sex
- All
- Age
- 60 Years
- Healthy volunteers
- Not accepted
Summary
Postoperative cognitive dysfunction (POCD) occurs mainly in aged patients. POCD may increase the mortality and morbidity. However, the mechanism of POCD is not clear yet and no effective therapy method was proved. According to our previous study, the central cholinergic system impaired by the anesthesia and surgery play a very important role in the POCD and donepezil an acetylcholinesterase inhibitor can prevent the POCD after isoflurane anesthesia in aged mice. Donepezil is a commercial medicine used for the Alzheimer Disease, which is tolerable and has minimal adverse events. In present study a multi-center randomized case control study was conducted and we hypothesized that donepezil attenuate the POCD.
Conditions
- Total Knee Arthroplasty
- Fracture of Head of Femur Articular Displaced
- Protrusion of Intervertebral Disc
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Donepezil | Donepezil a cholinesterase inhibitor, 5mg(1 pill)/ day for 7 days Po, was administrated from the day before surgery. |
| DRUG | Placebo | Placebo, 1 pill/ day for 7 days Po, was administrated from the day before surgery. |
Timeline
- Start date
- 2020-06-14
- Primary completion
- 2021-12-01
- Completion
- 2022-12-01
- First posted
- 2020-06-09
- Last updated
- 2020-12-29
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT04423276. Inclusion in this directory is not an endorsement.