Trials / Unknown
UnknownNCT05034029
Effect of Metformin on Patients With Osteoarthritis
Effect of Metformin on Tibiofemoral Cartilage Volume and Knee Symptoms Among Overweighted Knee Osteoarthritis patients-a Randomized Clinical Trial
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 262 (estimated)
- Sponsor
- Guangzhou First People's Hospital · Academic / Other
- Sex
- All
- Age
- 50 Years – 75 Years
- Healthy volunteers
- Not accepted
Summary
This randomized controlled trial aims to investigate if metformin has osteoarthritis protective effects among overweighted knee osteoarthritis patients. The co-primary outcomes are changes in tibiofemoral cartilage volume and Western Ontario and McMaster Universities Arthritis Index (WOMAC) from baseline to month 24. The secondary outcomes are changes in visual analog scale (VAS)-assessed knee pain, tibiofemoral cartilage defect, effusion-synovitis volume, and tibiofemoral bone marrow lesion maximum size from baseline to month 24.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Metformin hydrochloride sustained release tablets | Oral |
| DRUG | Placebo | Placebo |
Timeline
- Start date
- 2021-08-01
- Primary completion
- 2024-12-31
- Completion
- 2024-12-31
- First posted
- 2021-09-05
- Last updated
- 2022-01-06
Locations
5 sites across 1 country: China
Source: ClinicalTrials.gov record NCT05034029. Inclusion in this directory is not an endorsement.