Trials / Completed
CompletedNCT04657926
A Trial of APPA in the Treatment of Knee Osteoarthritis
A Placebo-controlled, Double-blinded, Randomized, Trial Using a Combination of Apocynin and Paeonol (APPA) for the Treatment of Knee Osteoarthritis
- Status
- Completed
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 152 (actual)
- Sponsor
- AKL Research and Development · Industry
- Sex
- All
- Age
- 18 Years – 75 Years
- Healthy volunteers
- Not accepted
Summary
A placebo controlled study of APPA in 150 participants with Osteoarthritis of the knee
Detailed description
This is a multicenter, randomized, double-blind, placebo-controlled, parallel group, 4-week trial of a fixed-dose combination of apocynin and paeonol (APPA) administered orally twice daily versus placebo twice daily. Approximately 150 subjects will be randomized to one of the two treatment groups.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | APPA | APPA, an oral combination of two isomers: 4-hydroxy-3-methoxyacetophenone (4H3MA) \& 2-hydroxy-4-methoxyacetophenone (2H4MA). |
| DRUG | Placebo | Placebo capsules |
Timeline
- Start date
- 2020-09-09
- Primary completion
- 2021-09-30
- Completion
- 2021-10-01
- First posted
- 2020-12-08
- Last updated
- 2021-11-17
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT04657926. Inclusion in this directory is not an endorsement.