NCT04654871

Effects of Glucosamine and Chondroitin Sulfate Supplementation in Addition to Resistance Exercise Training and Manual Therapy in Patients With Knee Osteoarthritis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Foundation University Islamabad · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Osteoarthritis (OA) IS one of the most common joint disorders, affecting not only the joints but also the surrounding muscles, which become weak. Resistance exercise reduces pain and improves function in patients with OA of the knee. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used by patients with OA to reduce pain and thereby maintain the ability to perform daily activities. However, there is accumulating evidence for a negative effect of NSAIDs, thus many patients with OA are treated with dietary supplementations such as glucosamine and chondroitin sulfate, and some studies show a beneficial effects on cartilage and pain. However, their effect on OA symptoms and cartilage remains controversial. Thus, it is important to investigate whether a potentially beneficial effect of glucosamine and chondroitin sulfate with resistance exercise and manual therapy in patients with knee OA.

Conditions

• Osteoarthritis
• Osteoarthritis, Knee

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Chondroitin Sulfate	Glucosamine 500 mg Chondroitin sulfate sodium 400mg 3/day
PROCEDURE	Resistance exercise training	Treadmill walking 5-10 min for warm up Strength training: (80% of 8RM) Supervised exercise thrice a week and Home Exercise 4 times a week Leg press knee extension Knee flexion Terminal knee extension Mini squats 3 sets 8 reps 10-15 s rep rest interval 1-2 min set rest interval
PROCEDURE	Manual therapy / Joint Mobilization	Ant. tib-fem glide Post tib-fem glide thrice a week Pattelo-femoral joint mobilization
PROCEDURE	THE therapy	Interferential and Heating for 20 min

Timeline

• Start date: 2020-01-01
• Primary completion: 2020-09-01
• Completion: 2020-11-01
• First posted: 2020-12-04
• Last updated: 2020-12-04

Locations

1 site across 1 country: Pakistan