| Recruiting | Study to Assess the Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]GRT6019 Healthy Male Volunteers | Phase 1 | 2026-03-25 |
| Recruiting | A First-in-human Trial of GRT7041 in Healthy Participants Treatment of Pain | Phase 1 | 2026-01-14 |
| Active Not Recruiting | A Trial to Investigate the Safety and Pharmacokinetics of GRT6019 in Healthy Male Participants Duchenne Muscular Dystrophy (DMD) | Phase 1 | 2026-01-06 |
| Completed | A Trial to Investigate Safety and Pharmacokinetics of GRT6019, Including Food Effect, in Healthy Male Particip Duchenne Muscular Dystrophy (DMD) | Phase 1 | 2025-11-21 |
| Completed | Comparison of a Single RTX-GRT7039 and Placebo Intra-articular Injection for Pain Associated With Osteoarthrit Osteoarthritis | Phase 3 | 2022-09-26 |
| Completed | Open-label Trial to Check the Safety and Tolerability of RTX-GRT7039 Injections for Pain Associated With Osteo Osteoarthritis | Phase 3 | 2022-09-15 |
| Completed | Efficacy and Safety of RTX-GRT7039 in Adult Subjects With Knee Osteoarthritis Osteoarthritis | Phase 3 | 2022-08-26 |
| Withdrawn | Bioequivalence of Two Fixed-dose Combination Tablets Containing Estradiol and Nomegestrol Acetate Bioequivalence | Phase 1 | 2019-10-01 |
| Withdrawn | A Study to Investigate Differences in the Extent and Rate of Absorption of Doxylamine/Pyridoxine From 2 Differ Bioavailability | Phase 1 | 2019-06-01 |
| Completed | Characterization of the Pharmacokinetics of a Vaginal Ring With 2.0 g Progesterone in Post-menopausal Women Pharmacokinetics | Phase 1 | 2018-11-01 |
| Terminated | A Clinical Study to Compare MAR-CUTIS With Dermabond Advanced Wounds and Injuries, Lacerations, Surgical Incision | N/A | 2018-10-30 |
| Completed | A Comparison of How Likely it is That Different Tablets of Oxycodone Will be Broken up and Snorted by Adults W Substance Abuse | Phase 1 | 2018-07-24 |
| Terminated | Efficacy and Safety of Intravenous Neridronic Acid in Complex Regional Pain Syndrome (CRPS) Complex Regional Pain Syndrome (CRPS) | Phase 3 | 2018-05-31 |
| Terminated | Efficacy and Safety of Intravenous Neridronic Acid in CRPS Complex Regional Pain Syndrome (CRPS) | Phase 3 | 2018-05-30 |
| Terminated | A Study in Healthy Male Volunteers to Investigate the Safety and Tolerability of a Single Dose of Neosaxitoxin Anesthesia, Anesthesia, Local, Analgesia | Phase 1 | 2018-01-30 |
| Withdrawn | A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of a New and a Mar Opioid-Related Disorders, Pain, Acute, Pain, Postoperative | Phase 1 | 2017-09-01 |
| Withdrawn | A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of Different Amoun Opioid-Related Disorders, Pain, Acute, Pain, Postoperative | Phase 1 | 2017-09-01 |
| Completed | Tramadol/Diclofenac Fixed-dose Combination Phase III Trial in Acute Pain After Third Molar Extraction Acute Pain | Phase 3 | 2017-08-26 |
| Completed | Administration of Tramadol and Ketorolac Separately and Simultaneously to Assess a Potential Pharmacokinetic I Pharmacokinetics | Phase 1 | 2017-06-05 |
| Completed | Safety of Intravenous Neridronic Acid in CRPS Complex Regional Pain Syndrome | Phase 3 | 2016-12-20 |
| Completed | Intra-articular Lopain (MTX-071) Phase I/IIa Study in Chronic Osteoarthritic Knee Joint Pain Osteoarthritis, Knee | Phase 1 | 2016-04-01 |
| Completed | Pharmacokinetic Non-interaction Study With a Fixed-dose Combination Tablet With Tramadol and Diclofenac Pharmacokinetics | Phase 1 | 2015-06-07 |
| Completed | A Study to Look at Tapentadol Tablets in Children and Adolescents in Pain Pain | Phase 2 / Phase 3 | 2015-04-29 |
| Completed | Efficacy and Safety of Intravenous Neridronic Acid in CRPS-I Complex Regional Pain Syndrome, Type I | Phase 2 / Phase 3 | 2015-04-01 |
| Completed | A Study to Look at Tapentadol Oral Solution in Children and Adolescents in Pain Acute Pain | Phase 3 | 2015-02-19 |
| Terminated | Use of Tapentadol Oral Solution for Pain After Surgery in Children From Newborn to Less Than 2 Years Old Moderate to Severe Acute Postoperative Pain | Phase 2 | 2014-11-05 |
| Completed | Efficacy Study of a Cervical Pessary Containing Progesterone for the Prevention of Preterm Delivery Preterm Birth | Phase 2 | 2013-09-02 |
| Completed | Tapentadol Prolonged Release (PR) Versus Oxycodone/Naloxone Prolonged Release in Severe Chronic Low Back Pain Back Pain, Low Back Pain, Neuropathic Pain | Phase 4 | 2013-04-01 |
| Completed | Pharmacokinetic, Efficacy and Safety Study of Tapentadol Oral Solution in Children With Postoperative Pain Postoperative Pain, Acute Pain | Phase 2 | 2012-11-01 |
| Completed | Efficacy and Tolerability of Lidocaine Plaster for Treatment of Long-term Local Nerve Pain Pain, Chronic Pain, Neuropathic Pain | Phase 3 | 2012-10-01 |
| Terminated | A Study to Assess the Safety and Efficacy of 7 Days Treatment With a Novel Analgesic in Subjects With Peripher Neuralgia | Phase 2 | 2012-02-01 |
| Completed | Intravenous Tapentadol in Post-Bunionectomy Pain Bunion, Pain | Phase 2 | 2011-09-01 |
| Terminated | Tapentadol in Chronic Malignant Tumour Related Pain Cancer, Chronic Pain, Pain | Phase 3 | 2011-03-01 |
| Completed | Comparison of Increasing Doses of Tapentadol Versus a Combination of Tapentadol and Pregabalin Low Back Pain, Neuropathic Pain | Phase 4 | 2011-03-01 |
| Terminated | Lidocaine 5% Medicated Plaster in Chronic Neuropathic Postoperative Pain Pain, Chronic Pain, Neuropathic Pain | Phase 2 | 2010-08-01 |
| Completed | Efficacy and Safety of EN3324 (Axomadol) in Subjects With Chronic Low Back Pain Chronic Low Back Pain | Phase 2 | 2009-12-01 |
| Terminated | A Trial in Painful Diabetic Peripheral Neuropathy With GRT3983Y Painful Diabetic Neuropathy | Phase 2 | 2009-11-01 |
| Terminated | Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low B Pain, Chronic Pain, Low Back Pain | Phase 3 | 2009-10-30 |
| Completed | Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low B Chronic Pain, Low Back Pain | Phase 3 | 2009-09-30 |
| Terminated | Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to O Chronic Pain, Osteoarthritis | Phase 3 | 2009-09-01 |
| Completed | Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to O Chronic Pain, Osteoarthritis | Phase 3 | 2009-09-01 |
| Completed | A Trial to Evaluate CG5503 Efficacy and Safety in Acute Pain After Bunionectomy Bunionectomy, Pain, Postoperative Pain | Phase 3 | 2007-09-01 |
| Completed | A Study to Evaluate Tapentadol (CG5503) in the Treatment of Chronic Tumor-Related Pain Compared With Placebo a Tumor, Pain | Phase 3 | 2007-07-01 |
| Completed | A Clinical Study in Healthy Adults Who Sometimes Take Drugs for Pleasure Which Aims to Evaluate Whether GRT015 Pain, Acute Pain | Phase 1 | 2007-06-21 |
| Terminated | A Study to Evaluate the Effectiveness and Safety of CG5503 (Tapentadol) in the Treatment of Chronic Tumor Rela Pain, Neoplasm, Cancer | Phase 3 | 2007-06-01 |
| Completed | A Study to Evaluate the Efficacy and Safety of CG5503 Prolonged Release (PR) in Subjects With Moderate to Seve Pain, Knee Osteoarthritis | Phase 3 | 2007-06-01 |
| Terminated | Single Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations (Proto Healthy | Phase 1 | 2007-05-01 |
| Completed | A Study to Evaluate the Efficacy and Safety of Tapentadol (CG5503) in the Treatment of Acute Pain After Abdomi Hysterectomy, Postoperative | Phase 3 | 2007-05-01 |
| Terminated | Multiple Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations (Pro Healthy | Phase 1 | 2007-05-01 |
| Completed | Bioequivalence Trial of a New Opioid Combination Compared to Reference Healthy | Phase 1 | 2007-02-01 |
| Completed | Efficacy and Safety of Topical Versus Systemic Treatment in Postherpetic Neuralgia and Diabetic Polyneuropathi Neuropathic Pain | Phase 3 | 2006-12-01 |
| Terminated | Multiple Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations Healthy | Phase 1 | 2006-10-01 |
| Terminated | Single Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations Healthy | Phase 1 | 2006-10-01 |
| Completed | A Clinical Study in Healthy Adults Who Sometimes Take Drugs for Pleasure to Investigate the Safety and Tolerab Pain, Acute Pain, Chronic Pain | Phase 1 | 2006-01-20 |
| Completed | Clinical Pilot Study in Healthy Men to Characterize the Uptake of Buprenorphine Into and Its Elimination From Pain | Phase 1 | 2005-11-07 |
| Completed | Drug-drug Interaction Study to Evaluate the Effect of Omeprazole on CG5503 (Tapentadol) Pharmacokinetic | Phase 1 | 2005-09-28 |
| Completed | Efficacy and Safety of GRT9906 Tablets Compared to Placebo in Patients With Fibromyalgia Primary Fibromyalgia | Phase 2 | 2005-09-19 |
| Completed | Pharmacokinetic Characterization of Two Novel CG5503 Tablet Formulations in Healthy Volunteers Pharmacokinetics | Phase 1 | 2005-04-01 |
| Completed | A Clinical Study in Healthy Subjects Which Aims to Investigate the Safety, the Tolerability and the Effects of Acute Pain | Phase 1 | 2004-12-30 |
| Completed | Acceptance of Clarithromycin in a Straw Compared to Syrup in Children With Upper Respiratory Tract Infections Otitis Media, Tonsillitis, Pharyngitis | Phase 3 | 2004-09-22 |
| Completed | Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GRT9906 Prolonged Release Tablets After Dose Es Pharmacokinetics | Phase 1 | 2004-09-15 |
| Completed | Clinical Study in Healthy Men to Investigate the Uptake of Buprenorphine and Its Elimination From the Body Aft Pain, Pharmacokinetics | Phase 1 | 2004-04-05 |
| Completed | Investigation How CG5503 is Taken up and Excreted From the Body After 2 Minutes Intravenous Infusion With and Pharmacokinetic | Phase 1 | 2004-02-01 |
| Completed | A Clinical Study in Healthy Women Which Aims to Explore the Intestinal Uptake of Two Different Tablets of GRTA Pain, Neuropathic Pain, Chronic Pain | Phase 1 | 2003-10-22 |
| Completed | A Study With Lidocaine 5% Medicated Plaster in Patients Suffering From Postherpetic Neuralgia Post Herpetic Neuralgia | Phase 3 | 2003-07-16 |
| Completed | A Study With Lido-Patch and Placebo Plaster in Patients Suffering From Postherpetic Neuralgia (PHN) Post Herpetic Neuralgia | Phase 3 | 2003-04-29 |
| Completed | Effect of a Multiple-dose Oral Administration of CG5503 PR on the Electrical Activity of the Heart in 48 Healt Prolonged QTc Interval, Pharmacokinetic | Phase 1 | 2003-03-01 |