NCT06946329

WATERinMOTION Aquatic Therapy in Obese Men With Knee Osteoarthritis

Mechanistic and Functional Outcomes of WATERinMOTION Aquatic Therapy in Obese Men With Knee Osteoarthritis: A Randomized Controlled Trial With 6-Month Follow-Up

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: University of Sistan and Baluchestan · Academic / Other
• Sex: Male
• Age: 45 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This RCT evaluates whether WATERinMOTION aquatic therapy improves pain, function, and quality of life more effectively than land-based exercise in obese men with knee osteoarthritis (OA). We will assess clinical outcomes (WOMAC), serum biomarkers (COMP, IL-6), and real-world activity (accelerometry) at baseline, 8 weeks, and 6 months.

Detailed description

100 participants (BMI ≥30, age 45-65, radiographic knee OA) will be randomized to: Aquatic group: 24 sessions over 8 weeks (3x/week) in 32°C water, progressing from buoyancy-assisted to resistance exercises. Land group: Matched duration/intensity land-based rehabilitation. Primary outcomes: WOMAC pain/function. Secondary outcomes: SF-36 quality of life, serum COMP, 6-minute walk test, and accelerometer-measured step count.

Conditions

• Osteoarthritis
• Knee
• Obesity

Interventions

Type	Name	Description
BEHAVIORAL	Aquatic Exercise	Supervised WATERinMOTION sessions (60 mins, 3x/week) in heated pool. Focus on progressive resistance and mobility exercises.
BEHAVIORAL	Land-Based Rehabilitation	Matched frequency/duration land-based program emphasizing core stabilization and low-impact aerobics.

Timeline

• Start date: 2024-03-01
• Primary completion: 2024-09-30
• Completion: 2025-05-01
• First posted: 2025-04-27
• Last updated: 2025-04-27

Locations

1 site across 1 country: Iran