NCT07006701

A Population-based Cohort of Osteoarthritis: the Tsinghua University Tiantongyuan Community Osteoarthritis Study

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 4,000 (estimated)
• Sponsor: Beijing Tsinghua Chang Gung Hospital · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: —

Summary

The purpose of this study is to examine the natural history and risk factors of osteoarthritis (OA) and to explore the relationship between metabolic factors and OA progression.

Detailed description

1. To investigate the natural history of osteoarthritis (OA) in a large-sample cohort. 2. To identify OA phenotypes and their relationship with clinical symptoms and functional impairment. 3. To analyze metabolic factors (e.g., obesity, diabetes, and hypertension) as risk factors for OA onset and progression. 4. To evaluate the association between radiographic changes and OA symptoms. 5. To develop predictive models for OA progression and identify high-risk individuals for early intervention. Design: This is a prospective cohort study. Participants: The study will recruit approximately 4,000 individuals aged 50 years and above. Participants will undergo baseline assessments, including demographic data collection, medical history, dietary evaluation, physical examination, blood sample collection, and radiographic imaging. Annual follow-ups will be conducted over 10 years to monitor OA progression and related risk factors.

Conditions

• Osteoarthritis

Timeline

• Start date: 2025-06-03
• Primary completion: 2034-12-31
• Completion: 2034-12-31
• First posted: 2025-06-05
• Last updated: 2025-06-05

Locations

1 site across 1 country: China