NCT01670305

Photodynamic Therapy and Periodontal Therapy. A Clinical, Microbiological and Immunoenzymatic Analysis

Photodynamic Therapy and Periodontal Therapy. A Clinical, Microbiological and Immunoenzymatic Analysis.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: Paulista University · Academic / Other
• Sex: All
• Age: 30 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Residual pockets and furcation defects are challenging sites that require additional periodontal therapy. The aim of this study is evaluate 1)the effect of a single photodynamic therapy (PDT) as monotherapy residual pockets in single rooted teeth and 2) the effect of PDT in association with scaling and root planing (SRP) in class II furcation lesions with probing pocket depth (PPD) \>5mm and bleeding on probing (BoP). A blind randomized controlled clinical trial was conducted in subjects presenting at least three residual pockets in single root teeth and subjects with at least one molar presenting class II furcation defect. To evaluate the effect of a single PDT as monotherapy in residual pockets, the selected sites were assigned to receive: PDT alone, photosensitizer alone or SRP alone. To evaluate the effect of PDT in association with SRP in class II furcation lesions, the selected sites were assigned to PDT+SRP or SRP alone. Clinical, microbiological and immunoenzymatic analyses were assessed at baseline, 3 and 6 months post-therapies.

Detailed description

Residual pockets and class II furcation lesions are challenging sites that require additional periodontal therapy. The aims of this study were to evaluate: 1\) the effect of a single PDT as monotherapy residual pockets in single rooted teeth and 2) the effect of PDT in association with SRP in class II furcation lesions. A blind randomized controlled clinical trial was conducted in subjects presenting at least three residual pockets in single root teeth and subjects with at least one molar presenting class II furcation involvement. To evaluate the effect of a single PDT as monotherapy in residual pockets, the selected sites were assigned to receive one of following therapies: PDT alone, photosensitizer alone or SRP alone. To evaluate the effect of PDT in association with SRP in class II furcation lesions, the selected sites were assigned to receive PDT+SRP or SRP alone. Microbiological, immunoenzymatic analyses and clinical parameters: probing pocket depth (PPD), position of the gingival margin (PGM), relative clinical attachment level (RCAL), full mouth plaque (FMPS) and bleeding score (FMBS), will be assessed at baseline,3 and 6 months post-therapies.

Conditions

• Periodontal Disease

Interventions

Type	Name	Description
PROCEDURE	Residual pockets will be treated by laser + photosensitizer	Experimental group: Residual pockets will be treated by laser + photosensitizer
PROCEDURE	Residual pockets will be treated only photosensitizer	Placebo Comparator: Residual pockets will be treated only photosensitizer
PROCEDURE	Residual pockets will be treated scaling and root planing	Active Comparator: Residual pockets will be treated scaling and root planing
PROCEDURE	laser + photosensitizer associated with scaling and root planing	Experimental group: furcation defects will be treated by laser + photosensitizer associated with scaling and root planing
PROCEDURE	furcation defects will be treated by scaling and root planing	Active Comparator: furcation defects will be treated by scaling and root planing

Timeline

• Start date: 2011-02-01
• Primary completion: 2011-05-01
• Completion: 2013-03-01
• First posted: 2012-08-22
• Last updated: 2013-09-12

Locations

1 site across 1 country: Brazil