NCT07520968

ABX Versus CHX in NSPT: a RCT

Enamel-repair Microcrystal Mouthwash Enriched With an Antibacterial Complex (ABX) Versus Chlorhexidine (CHX) Mouthwash as an Adjunct to Non-surgical Periodontal Therapy

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: University of Roma La Sapienza · Academic / Other
• Sex: All
• Age: 30 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The study aims to compare the efficacy of a novel mouthwash based on microRepair ABX and an antibacterial complex with that of 0.12% chlorhexidine, both used as adjuncts to scaling and root planing.

Detailed description

This study will be conducted in the Department of Odontostomatological and Maxillofacial sciences, in the Screening and Prevention Unit directed by me. Study Population Subjects diagnosed with periodontal disease and requiring non-surgical periodontal therapy were enrolled. Sample Size A total of 40 patients were included in the study, with 20 subjects allocated to each treatment group. Group A- TEST GROUP: NSPT+ ABX; GROUP B- CONTROL GROUP: NSPT+ CHX. All participants underwent a comprehensive periodontal examination, including full-mouth periodontal charting. Standardized intraoral periapical radiographs were obtained using positioning devices to assess radiographic bone loss. All patients subsequently received non-surgical periodontal therapy (NSPT) following a full-mouth disinfection protocol, performed with both hand and ultrasonic instruments. Oral hygiene instructions were reinforced at each scheduled visit. A first re-evaluation was conducted at 8 weeks, and a second re-evaluation at 6 months to assess periodontal stability. Patients in the control group received NSPT in combination with a 0.12% chlorhexidine mouthwash, administered twice daily for 60 seconds over a 14-day period starting immediately after completion of mechanical instrumentation. Patients in the test group received NSPT in combination with a high-density Biorepair Plus mouthwash, administered twice daily for 60 seconds over a 14-day period starting immediately after completion of mechanical instrumentation

Conditions

• Periodontal Disease
• Periodontal Disease Stage 2
• Periodontal Disease, AVDC Stage 3

Interventions

Type	Name	Description
OTHER	ABX Mouthwash as adjunctive to non surgical periodontal treatment	Group A: a novel mouthwash with microRepair ABX will be used for the first timen in adjunct to non surgical periodontal therapy
OTHER	CHX as adjunctive to non surgical periodontal treatment	Group B - chlorhexidine mouthwash in adjunct to nonsurgical periodontal therapy

Timeline

• Start date: 2025-09-09
• Primary completion: 2026-11-01
• Completion: 2027-03-01
• First posted: 2026-04-09
• Last updated: 2026-04-09

Locations

1 site across 1 country: Italy