NCT01201746

Influence of Periodontal Treatment on Systemic Inflammatory Mediators

Influence of Periodontal Treatment on Systemic Inflammatory Mediators:hsC-reactive Protein, Fibrinogen and White Blood Cells in CHD Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 317 (actual)
• Sponsor: Sheikh Zayed Federal Postgraduate Medical Institute · Academic / Other
• Sex: All
• Age: 31 Years
• Healthy volunteers: Not accepted

Summary

Currently the research issue in establishing the role of periodontal disease (PD) in coronary heart disease (CHD) risk is to define the pathways that lead to cause-effect relationship between PD and CHD. There is no consensus on definition of a periodontal disease case or the threshold level that may give clear indication for this relationship. Periodontal therapy has been used in different studies with the hope that a change in periodontal disease status may modify the factors associated with CHD risk. Many of these studies, on role of periodontal therapy in the reduction of CHD associated risk-factors, were based on small study samples, and very few studies were randomized controlled trials. So a need for large prospective studies is warranted in literature.----------- A single-blind parallel-arm randomized controlled clinical trial was designed to observe the influence of periodontal treatment on serum inflammatory mediators of hsC-reactive protein, white blood cells and fibrinogen in CHD patients. Hypothesis: Periodontal therapy in CHD patients, by reducing periodontal inflammation, may decrease the host systemic inflammatory burden associated with atherogenic processes.

Conditions

• Periodontal Disease
• Coronary Heart Disease

Interventions

Type	Name	Description
PROCEDURE	Delayed treatment	Scaling, Root Planing and oral hygiene instruction
PROCEDURE	Periodontal therapy	Scaling, root planning and oral hygiene instructions

Timeline

• Start date: 2008-07-01
• Primary completion: 2009-04-01
• Completion: 2009-05-01
• First posted: 2010-09-15
• Last updated: 2016-10-14

Locations

1 site across 1 country: Pakistan