NCT01785355

The Impact Of Periodontal Disease Treatment On The General Health Status In Chronic Haemodialyzed Patients

Periodontal Disease, Inflammation, Nutritional Status And Anaemia Response To Erythropoietin In Chronic Haemodialyzed Patients - The Impact Of Treatment For Periodontal Disease

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Anemia Working Group Romania · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Several studies revealed a direct relationship between the severity of periodontal inflammation and CRP (NHANES III, Dumitriu HT et al, 1998). In patients without any other source of inflammation but PDD, proper dental treatment of the disease decreased CRP to normal levels (Dumitriu H.T. et al., 1998; D'Aiuto F. et al, 2004; Borawski J. et al., 2007) Moreover, a direct link between high levels of CRP and atherosclerotic complications has been found in studies conducted both in general population (Ridker PM, et al., 1998; Koenig W, et al., 1999) and in HD subjects (Westhuyzen J, et al., 2000; Iseki K., et al., 1999; Zimmermann J, et al. 1998).

Detailed description

Patients will be recruited according to eligibility criteria. Initial oral and general status will be evaluated and recorded. The evaluated parameters are listed at the study description section. Also, quality of life will be assessed by using the SF-36 and OHIP-14 questionnaires. Patients will undergo a series of dental interventions with the final scope of eliminating all oral inflammation. Participants will also be instructed regarding correct oral hygiene habits. Following dental and periodontal treatments, the oral and general status will be reassessed and the obtained dat analysed.

Conditions

• Periodontal Disease
• Chronic Kidney Disease

Interventions

Type	Name	Description
OTHER	Dental treatment	1. The preliminary stage deals with: * assessment of the clinical state of the patient by completing a detailed dental and periodontal chart * education of the patient regarding correct oral hygiene habits; 2. Phase I Therapy: * plaque control : removal of dental plaque, calculus and root planning; antimicrobial therapy (local or systemic) * evaluation of response to the treatment 3. Phase II Therapy - surgical phase: * extraction of hopeless teeth * evaluation of the surgical results. 4. Maintenance phase: * periodic reevaluation of plaque and calculus and of periodontal conditions.

Timeline

• Start date: 2012-09-01
• Primary completion: 2021-09-01
• Completion: 2022-06-01
• First posted: 2013-02-07
• Last updated: 2019-07-23

Locations

1 site across 1 country: Romania