NCT02750956

Endocan, VEGF and TNF-alpha Levels in Periodontal Disease and After Treatment

Effect of Non-surgical Periodontal Treatment on Gingival Crevicular Fluid and Serum Endocan, Vascular Endothelial Growth Factor-A and Tumor Necrosis Factor Alpha Levels

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 40 (actual)
• Sponsor: Bulent Ecevit University · Academic / Other
• Sex: All
• Age: 25 Years – 49 Years
• Healthy volunteers: Accepted

Summary

The primer aim of the study was to determine serum and gingival crevicular fluid (GCF) endocan levels in periodontal diseases pathogenesis supported with vascular endothelial growth factor (VEGF) and tumor necrosis factor alpha (TNF-α) levels.

Detailed description

The study consist of three groups: periodontally healthy individuals (group 1; n = 20), individuals with generalized chronic periodontitis (group 2; n = 20), the same patients with chronic periodontitis after they had been treated with scaling and root planing (SRP) were considered as Group 3. Clinical measurements were recorded; GCF and serum samples were obtained from each participant before and 6 weeks after therapy. Endocan, VEGF-A and TNF-α levels were measured by enzyme-linked immunosorbent assay.

Conditions

• Periodontal Disease

Interventions

Type	Name	Description
PROCEDURE	Non-surgical periodontal treatment	Non-surgical periodontal therapy is an anti-infective therapy which includes both mechanical and chemotherapeutic approaches to minimize or eliminate microbial biofilm, the primary etiology of gingivitis and periodontitis

Timeline

• Start date: 2015-06-01
• Primary completion: 2015-12-01
• Completion: 2016-03-01
• First posted: 2016-04-26
• Last updated: 2016-04-26