NCT03227367

Osteoclast Impairment in Chronic Periodontitis by Regenerative Materials.

Platelet Rich Fibrin/Biphasic Calcium Phosphate Impairs Osteoclasts Differentiation and Promotes Apoptosis by the Intrinsic Mitochondrial Pathway in Chronic Periodontitis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Meenakshi Ammal Dental College and Hospital · Academic / Other
• Sex: All
• Age: 25 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The present study is an effort to investigate the hypothesis that Platelet Rich Fibrin/Biphasic Calcium Phosphate may play a role in inhibiting osteoclasts differentiation and in bone loss.

Detailed description

Study design Fifty-five individuals from a suburban population were recruited. Out of them, 5 individuals refused to participate in the study. Finally, 50 participants were selected and divided into two groups, control group \[Healthy individuals\]: 25 Males/Females, aged 25 to 35 years and test group \[Chronic periodontitis patients\]: 25 Males/Females aged 30 to 45 years. Demographic variables and periodontal parameters were measured in both the groups.The investigators explored the effect of Platelet rich fibrin (PRF)/Biphasic calcium phosphate (BCP) on differentiation and survival of osteoclasts obtained from peripheral blood of Chronic Periodontitis patients.

Conditions

• Periodontal Disease
• Periodontal Bone Loss
• Osteoclastic Bone Loss

Interventions

Type	Name	Description
OTHER	other : PRF	mononuclear cells from the peripheral blood of chronic periodontitis patients were intervened with PRF, BCP and PRF/BCP combination

Timeline

• Start date: 2014-03-17
• Primary completion: 2016-04-13
• Completion: 2017-03-18
• First posted: 2017-07-24
• Last updated: 2017-07-26