NCT02126267

Evaluation of Techniques for Scaling and Root Planing and One Stage Full Mouth Disinfection

Clinical and Microbiological Evaluation of Techniques for Scaling and Root Planing Per Quadrant and One Stage Full Mouth Disinfection Associated With Azithromycin or Chlorhexidine: Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 77 (actual)
• Sponsor: Centro Universitario de Lavras · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Evaluate and compare the effectiveness in a clinical and microbial perspective one stage full-mouth disinfection technique in relation to scaling and root planing per quadrant associated with chlorhexidine or azithromycin.

Detailed description

Seventy -seven systemically healthy subjects with chronic periodontitis were randomly included in 6 different predefined groups. The following periodontal parameters were evaluated: probing depth , clinical attachment level , plaque index, gingival index and percentage of areas affected by periodontal disease. Microbiologically were evaluated the bacterial load and specific load of five bacterias: The quantification of the bacteria was performed by real-time Polymerase Chain Reaction . The clinical and microbial baseline evaluations were performed ( periodontal pre- therapy) , 90 and 180 days after treatment.

Conditions

• Periodontal Disease
• Chronic Periodontitis

Interventions

Type	Name	Description
PROCEDURE	Scaling and root planing	Scaling procedures were performed per quadrant (30 min. per quadrant) at weekly intervals between sessions;
PROCEDURE	Full mouth disinfection	Procedures for scaling and root planing were performed in a single stage (24 hours) divided into two sessions (60 min per session) on two consecutive days
DRUG	Chlorhexidine gel and gluconate	application of chlorhexidine (CX) (1%) gel in pockets after scaling, brushing tongue for 1 min. with CX (1%) gel and mouthwash at the beginning and end of each session with CX 0.2% for 30 seconds (with the form of a gargle in the last 10 seconds)
DRUG	Chlorhexidine gluconate solution	Home use fo CX 0.2% for 60 consecutive days after the end of the first session of scaling.
DRUG	Azithromycin	Azithromycin (500 mg) once daily for 3 consecutive days.

Timeline

• Start date: 2013-01-01
• Primary completion: 2014-02-01
• Completion: 2014-03-01
• First posted: 2014-04-29
• Last updated: 2014-04-29

Locations

1 site across 1 country: Brazil