| Recruiting | Vector® System vs Mini-Five Curettes in Non-Surgical Periodontal Therapy NCT07452640 | Hacettepe University | N/A |
| Not Yet Recruiting | Metformin Versus Chlorhexidine Gel as Adjuncts to Scaling and Root Planing in Stage II Grade B Periodontitis NCT07215156 | Kafrelsheikh University | N/A |
| Completed | Role of NLRP6 in Chronic Periodontitis NCT06400069 | Babol University of Medical Sciences | — |
| Recruiting | Study on Treatment Results and Bone Changes After Replanting Severely Affected Teeth - A Before-and-After Stud NCT06893107 | University of Fujairah | N/A |
| Completed | Efficacy of Herbal Dentifrice in Treatment of Chronic Periodontitis NCT06043687 | Dr. D. Y. Patil Dental College & Hospital | Phase 3 |
| Completed | Efficacy of Herbal Dentifrice for Management of Dentinal Hypersensitivity NCT05852366 | Dr. D. Y. Patil Dental College & Hospital | Phase 3 |
| Unknown | NSPT On Vitronectin And Fetuin-A Levels In Patients With Periodontitis And Coronary Artery Disease NCT05663476 | Meenakshi Ammal Dental College and Hospital | N/A |
| Withdrawn | Effectiveness of Non-surgical Periodontal Treatment on HbA1c Levels in a Patient With Type 2 Diabetes Mellitus NCT04051866 | Gerencia de Atención Primaria, Madrid | N/A |
| Completed | Evaluation of Acacia Catechu and Low-Level Laser in the Treatmentof Stage II Periodontitis NCT06805292 | Faculty of Dental Medicine for Girls | N/A |
| Completed | Estimation of (suPAR) in Chronic Periodontitis With Post-radiotherapy on HNCs Patients NCT06529588 | Al-Maarif University College | — |
| Completed | suPAR is a Potential Biomarker of in Chronic Periodontitis Through the Impact of Post-radiotherapy on HNCs Pat NCT06481059 | Al-Maarif University College | — |
| Recruiting | Utilization of a Videoscope in Periodontal Regeneration NCT05275192 | University of Illinois at Chicago | N/A |
| Completed | Perio. Maint. With Diode LBR NCT05276817 | Biolase Inc | Phase 1 |
| Completed | Bovine Bone With or Without Concentrated Growth Factor in the Treatment of Chronic Periodontitis NCT07108790 | Tanta University | N/A |
| Not Yet Recruiting | The Link Between Periodontitis, Smoking and Oral Cancer NCT04047212 | Cairo University | — |
| Unknown | NSPT on Calprotectin and Periostin Levels NCT05618743 | Meenakshi Ammal Dental College and Hospital | N/A |
| Completed | To Study the Healing Effect of 0.25% Lemongrass Oil Mouthwash on Chronic Periodontitis Patients. NCT05502627 | Postgraduate Medical Institute, Lahore | — |
| Unknown | Effect of Frankincense Extract Gel on Non-Surgical Treatment of Chronic Periodontitis NCT05005767 | Tanta University | Phase 2 |
| Completed | Beta-Tricalcium Phosphate and Concentrated Growth Factors in Treatment of Intra-bony Defect Randomized Clinica NCT04698317 | Tanta University | Phase 2 |
| Completed | Regenerative Potential of Advanced Platelet Rich Fibrin and Bioactive Glass (Perioglas®). NCT04767243 | Maharishi Markendeswar University (Deemed to be University) | Phase 4 |
| Completed | CBD Effects on Periodontal Health of Patients With Chronic Periodontitis NCT05498012 | Palacky University | Phase 1 / Phase 2 |
| Unknown | Comparative Study of APRF/CGF Technology in GTR NCT04953260 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Completed | A Study to Evaluate the Efficacy and Safety of ALH-L1005 in Patients With Chronic Periodontitis NCT04503746 | AngioLab, Inc. | Phase 2 |
| Completed | Antimicrobial Photodynamic Therapy in Chronic Periodontitis and Diabetes Mellitus NCT04857346 | King Saud University | Phase 2 / Phase 3 |
| Unknown | Clinical and Anti-inflammatory Effect of Curcumin Oral Gel as Adjuncts in Treatment of Periodontal Pocket NCT04355416 | University of Baghdad | EARLY_Phase 1 |
| Completed | Evaluation Efficacy of Melatonin Gel as Adjunctive Therapy in Chronic Periodontitis NCT05759416 | Al-Azhar University | Phase 4 |
| Unknown | Comparison of Clinical and Radiographic Parameters in the Application of Cross-linked Hyaluronic Acid 1.8% and NCT04274244 | University of Valencia | Phase 4 |
| Completed | Treatment of Periodontitis in Menopausal Patients NCT06254118 | Hadir F. El-Dessouky | Phase 4 |
| Completed | Evaluation of Indian Gooseberry/ Amla in the Management of Chronic Periodontitis NCT07531823 | Mahatma Gandhi Postgraduate Institute of Dental Sciences | N/A |
| Unknown | Effect of the Diode Laser on Bacteremia Associated With Periodontal Flap Surgery: A Clinico-Microbiological St NCT04207034 | Krishnadevaraya College of Dental Sciences & Hospital | N/A |
| Completed | Comparison of the Effect of Gingival Massage of Aloe-vera Gel and Sidr Honey on Chronic Periodontitis NCT05231096 | Dow University of Health Sciences | N/A |
| Unknown | Evaluation of Possible Genes in Periodontal Diseases by Genetic Methods NCT04026828 | Kocaeli University | — |
| Unknown | Injectable Platelet Rich Fibrin With Non Surgical Periodontal Therapy NCT04070729 | Institute of Dental Sciences, Bareilly, Uttar Pradesh, India | N/A |
| Completed | Comparison of the Effectiveness of Hypochlorous Acid and Chlorhexidine as a Post-surgical Antimicrobial Agent NCT05952921 | Universidad El Bosque, Bogotá | N/A |
| Unknown | The Effect of Zinc on the Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patient NCT03923829 | Cairo University | N/A |
| Unknown | Adjunctive Use of Salvadora Persica in Chronic Periodontitis NCT03749369 | King Saud University | EARLY_Phase 1 |
| Completed | Impact of Photodynamic Therapy as an Adjunct to Non-surgical Periodontal Treatment on Clinical and Biochemical NCT05122117 | Zohaib Akram | N/A |
| Unknown | PDT As An Adjunct To SRP In The Management of Chronic Periodontitis NCT03770819 | KLE Society's Institute of Dental Sciences | N/A |
| Unknown | Use of the xCELLigence System for Quantification of Bacterial Biofilm's Real Time Formation and Antibiotics Se NCT03863249 | University of Valencia | Phase 4 |
| Completed | Complex Phytoadaptogenes in Chronic Periodontitis Treatment. NCT04623164 | Vladikavkaz Scientific Center of the Russian Academy of Sciences | Phase 4 |
| Active Not Recruiting | Minimally-invasive Non-surgical Therapy of Intrabony Defects NCT03741374 | Queen Mary University of London | N/A |
| Completed | New Periodontitis Treatment Based on Hyaluronic Acid and Melatonin NCT03656484 | Concordia Dent Srl | Phase 2 |
| Completed | Effects of Herbal Mouth Rinse for Chronic Periodontitis NCT04074915 | Institute of Dental Sciences, Bareilly, Uttar Pradesh, India | N/A |
| Completed | Interplay of miRNA-146a and miRNA-126 in Chronic Periodontitis Patients With Coronary Artery Disease NCT04583085 | Meenakshi Ammal Dental College and Hospital | — |
| Completed | Nanocrystalline Hydroxyapatite Bone Substitute for Treating Periodontal Intrabony Defects NCT04643288 | Weam Ahmed Elbattawy | N/A |
| Completed | The Adjunctive Effect of Probiotics to Non Surgical Treatment of Chronic Periodontitis NCT04697199 | Tanta University | Phase 1 |
| Completed | Evaluation of Local Delivery of Aloe Vera Gel as an Adjunct to Non-surgical Treatment in Patients With Chronic NCT04615585 | Nourhan M.Aly | N/A |
| Active Not Recruiting | Comparing Inflammatory Markers in Patients With and Without Depression With Chronic Periodontitis NCT03553095 | University of Alabama at Birmingham | N/A |
| Completed | Autologous Fibrin Glue Application as an Adjunct to Nonsurgical Periodontal Treatment of Chronic Periodontitis NCT04082949 | Inonu University | EARLY_Phase 1 |
| Unknown | Porous Metronidazole Loaded Matrix for Local Treatment of Periodontitis. NCT03791099 | Wroclaw Medical University | Phase 4 |
| Unknown | Identification of EMT Indicators in Healthy and Periodontally Diseased Gingival Samples NCT03462953 | Cairo University | N/A |
| Completed | Teh Effect of Subgingival Irrigation Wif Ketorolac and Chlorhexidine in Patients Wif Chronic Periodontist NCT03836781 | Amirhossein Farahmand | Phase 2 / Phase 3 |
| Completed | Evaluation of Antimicrobial Photodynamic Therapy in Multiple Applications as a Coadjuvant in the Surgical Ther NCT03498404 | University of Sao Paulo | Phase 4 |
| Completed | Tissue Plasminogen Activator & Plasminogen Activator Inhibitor Type-1 In Gingival Tissues Of Chronic Periodont NCT03803176 | Cairo University | — |
| Completed | Thyroid Disease and Chronic Periodontitis NCT03369405 | University at Buffalo | — |
| Completed | Assessment of Response to the Conventional Periodontal Treatment Based on the Blood Group Phenotypes. NCT03644901 | Damascus University | — |
| Completed | Glycemic Control in T2DM Through Non-Surgical Periodontal Therapy NCT03343366 | Dow University of Health Sciences | Phase 2 / Phase 3 |
| Completed | Influence of Gingival Biotype on the Outcome of Open Flap Debridement NCT03882138 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Completed | Effect of Ashwagandha on Salivary Antioxidant and Serum c Reactive Protein in Chronic Generalized Periodontiti NCT03533972 | Tatyasaheb Kore Dental College | Phase 1 / Phase 2 |
| Completed | Effect Of A Locally Delivered Probiotic Sacchraomyces Boulardii In The Management Of Chronic Periodontitis NCT03516370 | Tatyasaheb Kore Dental College | Phase 1 / Phase 2 |
| Completed | Effect of Switching From Cigarette Smoking to the Use of IQOS on Periodontitis Treatment Outcome NCT03364751 | Philip Morris Products S.A. | N/A |
| Completed | Novel PAradigm to Improve Inflammatory Burden in ESRD (rePAIR): A Pilot and Feasibility Randomized Controlled NCT03241511 | UConn Health | N/A |
| Completed | Adjunctive Probiotics in Chronic Periodontitis NCT03499184 | Ziauddin Hospital | N/A |
| Completed | GCF IL-17 Levels and Oxidative Status of Smoking and Non-smoking Individuals With Periodontitis NCT04115176 | Ondokuz Mayıs University | — |
| Unknown | Amoxicillin to Prevent Bacteria and Inflammatory Biomarkers After Intensive Periodontal Therapy NCT03354338 | Universidad El Bosque, Bogotá | Phase 2 |
| Unknown | Comparison of Salivary Interleukin-1β and Matrix Metalloproteinase-8 Levels in Individuals With Chronic Period NCT03270280 | University of Health Sciences Lahore | Phase 2 |
| Unknown | Effects of Scaling and Root Planing With and Without Er:YAG Laser in Chronic Periodontitis Patients NCT03003689 | Tufts University School of Dental Medicine | N/A |
| Completed | Hyaluronic Acid With Scaling & Root Planing In Chronic Periodontitis Patients With Diabetes Mellitus Type 2 NCT03807596 | Cairo University | N/A |
| Completed | Interaction Between Immune Cells and Bacteria Associated With Periodontitis NCT03225950 | University of Copenhagen | — |
| Completed | Tissue Alterations in Aggressive and Chronic Periodontitis NCT03625414 | Tokat Gaziosmanpasa University | — |
| Completed | Chronic Periodontitis in Critically Ill Patients: Diagnosis and Epidemiology NCT02672384 | University Hospital, Brest | N/A |
| Completed | Apoptotic Changes in Gingiva Caused by Smoking NCT03631498 | Tokat Gaziosmanpasa University | — |
| Completed | Different Surgical Modalities in the Treatment of Periodontitis NCT01642641 | Queen Mary University of London | N/A |
| Unknown | Influence of Mouth Breathing on Periodontal Healing NCT03169322 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Completed | Dose Parameters for Photodynamic Therapy on Periodontal Disease NCT03262077 | University of Nove de Julho | N/A |
| Unknown | Prevalence of Porphyromonas Gingivalis Fimbrial Subunit Genotype in Smokers and Nonsmokers After Periodontal T NCT02879903 | Universidade Federal Fluminense | EARLY_Phase 1 |
| Unknown | Laser Assisted Nonsurgical Periodontal Treatment NCT03387371 | Bezmialem Vakif University | N/A |
| Completed | Chronic Periodontitis Microbiota in Type 2 Diabetes Mellitus Patients NCT03786133 | University of Bologna | — |
| Unknown | Effects of Omega-3 Plus Low-dose Aspirin as Adjunct to Periodontal Debridement for Chronic Periodontitis in Di NCT02800252 | Universidade Estadual Paulista Júlio de Mesquita Filho | N/A |
| Completed | Alterations in Subgingival Microbiota and Hypoxia in Occlusal Trauma NCT03621891 | Tokat Gaziosmanpasa University | — |
| Completed | To Compare Efficacy of Low Dose Diclofenac (25mg) in Management of Postoperative Pain After Periodontal Flap S NCT03519152 | Tatyasaheb Kore Dental College | Phase 1 / Phase 2 |
| Completed | Local Host Modulating Agents Alendronate & Aloe Vera for Treatment of Furcation Defects in Chronic Periodontit NCT03204097 | Government Dental College and Research Institute, Bangalore | Phase 2 / Phase 3 |
| Completed | Serum TRAP-5b Levels in Patients With Generalized Chronic Periodontitis NCT03043066 | Meenakshi Ammal Dental College and Hospital | N/A |
| Completed | Adjunct Photodynamic Therapy in Chronic Periodontitis Among Cigarette-smokers. NCT03308019 | King Saud University | N/A |
| Completed | Locally Delivered Metformin & Rosuvastatin for Treatment of Intrabony Defects in Chronic Periodontitis NCT03204058 | Government Dental College and Research Institute, Bangalore | Phase 2 / Phase 3 |
| Completed | Locally Delivered Metformin and Aloe Vera for Treatment of Intrabody Defects in Chronic Periodontitis NCT03204071 | Government Dental College and Research Institute, Bangalore | Phase 2 / Phase 3 |
| Completed | Periodontal Therapy in Thalassemia Major Patients NCT03311243 | King Saud University | N/A |
| Completed | Effect of Pranayama on Periodontal Health NCT02967861 | Meenakshi Ammal Dental College and Hospital | EARLY_Phase 1 |
| Completed | Simvastatin Gel With Perforated Resorbable Membranes in Treatment of Intrabony Defects in Chronic Periodontiti NCT03419429 | Ain Shams University | Phase 4 |
| Unknown | Efficacy of AloeVera Gel Gum Massaging and Adjunct to Scaling and Root Planing in Chronic Periodontitis Patien NCT03083535 | Government College of Dentistry, Indore | N/A |
| Completed | Effect of Tooth Cleaning in Smokers and Non Smokers With Gum Disease. NCT02930356 | Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre | N/A |
| Completed | Efficacy of Turmeric in Gingival Massaging and Adjunct to Scaling and Root Planing in Chronic Periodontitis Pa NCT02890771 | Government College of Dentistry, Indore | N/A |
| Completed | A Phase II Clinical Trial of YH23537 in Patients With Chronic Periodontal Disease. NCT02585596 | Yuhan Corporation | Phase 2 |
| Completed | Estimation of Pentrexin-3 Levels in GCF and Saliva of Patients With Periodontal Disease NCT03128502 | Cairo University | — |
| Terminated | Effect of Periodontal Therapy in the Systemic Status of Individuals With Chronic Periodontitis and Diabetes Ty NCT02589314 | University of Brasilia | — |
| Completed | 1.2% Rosuvastatin Subgingivally Delivered In Chronic Periodontitis With Type 2 Diabetes Mellitus NCT02985099 | Government Dental College and Research Institute, Bangalore | Phase 2 / Phase 3 |
| Completed | Gingival Crevicular Fluid Levels of Protein Carbonyl Following the Use of Lycopene in Chronic Periodontitis NCT03203746 | Maie Sami tawfik | Phase 1 / Phase 2 |
| Completed | microRNA 155 Levels and Periodontal Microflora (Bacteria and Virus) in Preeclampsia. NCT04277390 | Meenakshi Ammal Dental College and Hospital | — |
| Completed | Non-surgical Peridontal Treatment on Cardiovascular Risk Markers NCT04540328 | Kırıkkale University | N/A |
| Completed | To Study the Beneficial Effect of Mustard Oil and Salt Massaging With Oral Prophylaxis in Patients With Gum Di NCT02638740 | Government College of Dentistry, Indore | N/A |
| Completed | Evaluation of Local Doxycycline in Smokers With Chronic Periodontitis NCT02726646 | University of Campinas, Brazil | Phase 2 |
| Completed | Evaluation of Amnion Chorion Membrane and Demineralized Bone Matrix Putty Allograft in Periodontal Intrabony D NCT02679209 | Cairo University | N/A |
| Unknown | Efficacy of Oral Probiotic and Antibiotic Administration in Patients With Chronic Periodontitis NCT02839408 | University of Chile | Phase 2 |
| Completed | 1.2% Rosuvastatin Gel As A Local Agent In Smokers With Chronic Periodontitis NCT03043196 | Government Dental College and Research Institute, Bangalore | Phase 2 / Phase 3 |
| Completed | Effect of Arthrospira Platensis (Spirulina) as an Adjunct to Scaling and Root Planing on Salivary Antioxidant NCT02886676 | Tatyasaheb Kore Dental College | Phase 4 |
| Completed | Locally Delivered Atorvastatin & Rosuvastatin for Treatment of Furcation Defects in Chronic Periodontitis NCT02800902 | Government Dental College and Research Institute, Bangalore | Phase 2 / Phase 3 |
| Completed | Clinical Efficacy of 0.75% Boric Acid Gel in Chronic Periodontitis NCT02903108 | Government Dental College and Research Institute, Bangalore | Phase 2 / Phase 3 |
| Recruiting | B Cell Functions in Periodontitis NCT02833285 | University Hospital, Brest | — |
| Unknown | Amoxicillin and Metronidazole During Periodontal Treatment NCT02954393 | Belén Retamal-Valdes | N/A |
| Completed | Smoking Influence on Apoptosis in Periodontitis NCT02111005 | Damascus University | — |
| Completed | Effect on Teeth and Gum Cleaning in Patients With Gum and Kidney Disease NCT02901743 | Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre | Phase 4 |
| Completed | Comparison Between Two Non-surgical Periodontal Treatment Procedures With and Without Interdental Hygiene Devi NCT04339309 | Cairo University | N/A |
| Terminated | Influence of Periodontal Diseases on Vascular Parameters in Patients Suffering of Hypertension NCT02394860 | University Hospital, Strasbourg, France | — |
| Completed | Evaluation of the Efficacy of Probiotics in Chronic Periodontitis Patients NCT02390687 | Next Gen Pharma India Pvt. Ltd. | Phase 3 |
| Completed | Evaluation of Nano-crystalline Hydroxyapatite Silica Gel in Management of Periodontal Intrabony Defects NCT02507596 | Cairo University | N/A |
| Completed | Grape Seeds Extract Gel as an Adjunct for the Treatment of Chronic Periodontitis NCT02767115 | Riyadh Colleges of Dentistry and Pharmacy | Phase 2 |
| Unknown | Efficacy and Safety of a Commercially Available Injectable Hyaluronic Acid Dental Filler for Periodontal Pocke NCT02391974 | Teoxane SA | Phase 4 |
| Completed | Pre-procedural Mouthwash in Reducing Bacteria in Dental Aerosols NCT02875769 | University of Guarulhos | Phase 3 |
| Completed | Estimation of Pentraxin3 and PGingivalis Levels in Patients With Knee Joint and Gum Diseases NCT02503046 | Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre | — |
| Completed | Effect of Probiotics on Chronic Periodontitis in Smoker and Non- Smokers NCT02329353 | Next Gen Pharma India Pvt. Ltd. | Phase 3 |
| Completed | Impact of Periodontal Treatment on Serum Levels of Hepcidin and Hemoglobin NCT02641210 | Federal University of Maranhao | Phase 4 |
| Completed | Platelet-rich Fibrin With 1.2% Rosuvastatin in Chronic Periodontitis Treatment NCT02645227 | Government Dental College and Research Institute, Bangalore | Phase 2 / Phase 3 |
| Completed | IL-34 Levels in Various Types of Periodontitis NCT04223869 | Bulent Ecevit University | N/A |
| Completed | Effect of Scaling and Root Planing on Serum Renal Function Markers in Chronic Periodontitis Subjects. NCT02636114 | Maharashtra University of Health Sciences | N/A |
| Completed | Effectiveness of Locally Delivered Morus Alba Gel on Moderate Periodontitis NCT03475394 | KLE VK Institute of Dental Sciences | N/A |
| Completed | Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor NCT03171675 | Ain Shams University | — |
| Completed | Comparison of Rosuvastatin With Atorvastatin in Chronic Periodontitis NCT02600520 | Government Dental College and Research Institute, Bangalore | Phase 2 / Phase 3 |
| Completed | 1% Metformin Gel in the Treatment of Class II Furcation Defects NCT02580331 | Government Dental College and Research Institute, Bangalore | Phase 2 / Phase 3 |
| Completed | Advantages of Autologous Platelet-Rich Fibrin Membrane on Growth Factor Levels and Periodontal Healing NCT02898675 | Ataturk University | N/A |
| Completed | Combined Use of Er:YAG and Nd:YAG Laser NCT02851823 | Izmir Katip Celebi University | N/A |
| Completed | Platelet Rich Fibrin+1% Alendronate in Treatment of Chronic Periodontitis NCT02518152 | Government Dental College and Research Institute, Bangalore | Phase 2 / Phase 3 |
| Completed | Effects of Ozone Therapy on Clinical Parameters and Inflammatory Cytokines in Chronic Periodontitis Patients NCT03874390 | Ataturk University | N/A |
| Completed | Evaluation of Antimicrobial Photodynamic Therapy as an Adjunct to Periodontal Treatment in Smokers NCT03039244 | University of Sao Paulo | N/A |
| Completed | Comparison of Autologous PRF, 1% Alendronate and 1.2% Atorvastatin Gel in Chronic Periodontitis Treatment NCT02516111 | Government Dental College and Research Institute, Bangalore | Phase 2 / Phase 3 |
| Completed | Effect of Probiotic Inersan and Doxycycline in Chronic Periodontitis NCT02174757 | CD Pharma India Pvt. Ltd. | Phase 3 |
| Unknown | Effect of Periodontal Treatment on Salivary Biomarkers NCT02159781 | The Baruch Padeh Medical Center, Poriya | N/A |
| Completed | Gingival Crevicular Fluid Vaspin and Omentin Levels in Type 2 Diabetic Patients With Chronic Periodontitis NCT02544347 | Bulent Ecevit University | N/A |
| Completed | Effect of Omega 3 on Periodontitis in Postmenopausal Women NCT02764879 | October 6 University | Phase 2 |
| Completed | Efficacy of a Probiotic Lozenges in Chronic Periodontitis Patients. NCT02121665 | CD Pharma India Pvt. Ltd. | Phase 3 |
| Completed | Comparison of Alendronate With Atorvastatin in Chronic Periodontitis NCT02455869 | Government Dental College and Research Institute, Bangalore | Phase 2 / Phase 3 |
| Completed | Alendronate Compared to Metformin in Chronic Periodontitis NCT02461667 | Government Dental College and Research Institute, Bangalore | Phase 2 / Phase 3 |
| Completed | Chemerin and IL-6 Levels in Diabetes and Periodontitis NCT02596581 | Bulent Ecevit University | N/A |
| Unknown | Efficacy of Oral Probiotic Administration in Patients With Chronic Periodontitis NCT02283736 | Jorge Gamonal | Phase 2 |
| Completed | IgY Efficacy on Periodontitis Patients NCT02705885 | Immunology Research Institute in Gifu | N/A |
| Completed | Locally Delivered Aloe Vera Gel in the Treatment of Chronic Periodontitis Patients With Diabetes Mellitus NCT02437747 | Dr. D. Y. Patil Dental College & Hospital | Phase 4 |
| Completed | Aloe Vera in Chronic Periodontitis With Type 2 Diabetes Mellitus NCT02386020 | Government Dental College and Research Institute, Bangalore | Phase 2 / Phase 3 |
| Completed | Relationship Between Chronic Periodontitis and Vitamin D and Calcium in Men NCT02127346 | Damascus University | — |
| Completed | Disruption of Immune Homeostasis in Type 2 Diabetics With Generalized Chronic Periodontitis NCT02172716 | University of Sao Paulo | N/A |
| Completed | Nitro-oxidative Stress in Periodontitis NCT02127203 | Damascus University | — |
| Completed | Effects of Adjunct Photodynamic Therapy in the Treatment of Type 2 Diabetic Patients With Chronic Periodontiti NCT02627534 | Universidade Estadual Paulista Júlio de Mesquita Filho | N/A |
| Unknown | Diagnosis of Periodontal Disease Using Genetic Marker in Saliva NCT02069574 | Asan Medical Center | N/A |
| Completed | Autologous Alveolar Bone Marrow Mesenchymal Stem Cells for the Reconstruction of Infrabony Periodontal Defects NCT02449005 | Aristotle University Of Thessaloniki | Phase 1 / Phase 2 |
| Unknown | Intervention Study of Two Protocols for Non-surgical Treatment of Chronic Periodontitis NCT02168621 | Göteborg University | N/A |
| Completed | Effect of a Locally Delivered Probiotic in Periodontitis NCT02645669 | SVS Institute of Dental Sciences | Phase 2 |
| Completed | Treatment of Chronic Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy NCT02734784 | University of Sao Paulo | Phase 4 |
| Completed | Low-level Laser Therapy in the Treatment of Chronic Periodontitis in Type 2 Diabetics NCT02817152 | Universidade Estadual Paulista Júlio de Mesquita Filho | N/A |
| Completed | The Effectiveness of Titanium-Prepared Platelet-Rich Fibrin on Angiogenic Biomarkers in Gingival Crevicular Fl NCT02692079 | Kırıkkale University | N/A |
| Terminated | Effect of Disinfective Solution as an Adjunct to Maintenance Therapy of Inflamed Periodontal Pockets NCT02316652 | University of Nebraska | N/A |
| Completed | Decontaminant Agent in the Treatment of Chronic Periodontitis NCT02657096 | University of Messina | N/A |
| Completed | Furcation Therapy With Enamel Matrix Derivative NCT02907528 | Ohio State University | N/A |
| Completed | Efficacy of Locally Delivred 1.2% Rosuvastatin Gel in Chronic Periodontitis NCT02283515 | Government Dental College and Research Institute, Bangalore | Phase 2 / Phase 3 |
| Completed | Determining the Relationship Between the Atherosclerosis and Periodontopathogenic Microorganisms NCT02977351 | Izmir Katip Celebi University | N/A |
| Completed | RELATIONSHIP BETWEEN INITIAL PROBING DEPTH AND CHANGES IN CLINICAL PARAMETERS FOLLOWING NON-SURGICAL PERIODONT NCT02861326 | Marmara University | N/A |
| Completed | Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel NCT02442453 | Tatyasaheb Kore Dental College | Phase 4 |
| Completed | Evaluation of SilOss® in Periodontal Surgery NCT02639572 | SVS Institute of Dental Sciences | Phase 2 |
| Completed | Simvastatin and Metformin in Chronic Periodontitis NCT02372656 | Government Dental College and Research Institute, Bangalore | Phase 2 / Phase 3 |
| Terminated | Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis NCT01993368 | Centre Hospitalier Universitaire de Nice | N/A |
| Completed | Atorvastatin in the Treatment of Mandibular Degree II Furcation Defects NCT02386033 | Government Dental College and Research Institute, Bangalore | Phase 2 / Phase 3 |
| Completed | Changes of GCF Levels of RANKL and Osteoprotegerin in Postmenopausal Osteoporosis NCT02808988 | Ondokuz Mayıs University | Phase 4 |
| Completed | Burs Versus Curettes in Root Planing. NCT02875470 | Ege University | Phase 1 |
| Completed | Leptin and Visfatin in Diabetic Patients With Periodontitis Before and After Periodontal Therapy NCT02174146 | Cairo University | N/A |
| Terminated | Influence of Stress on Non Surgical Periodontal Treatment NCT02568163 | University Hospital, Strasbourg, France | N/A |
| Completed | Efficacy of Subgingivally Delivered Doxycycline Plus Ketoprofen Gel as an Adjunct to Non-surgical Periodontal NCT02538224 | Islamic Azad University, Sanandaj | Phase 2 / Phase 3 |
| Completed | Efficacy of a Probiotic Lozenge (Inersan) in Patients With Chronic Periodontitis NCT01870362 | CD Pharma India Pvt. Ltd. | Phase 3 |
| Completed | Photodynamic Therapy During Supportive Periodontal Therapy NCT02666573 | National University of Singapore | Phase 4 |
| Completed | The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Peri NCT02355977 | Zhejiang University | Phase 4 |
| Completed | Effect of Non-surgical Periodontal Treatment on HbA1c in Type 2 Diabetic Patients NCT02652026 | University of Barcelona | N/A |
| Completed | Short-term Effect of 2% Atorvastatin Dentifrice in Periodontal Status. NCT01929135 | Universidad de los Andes, Chile | Phase 2 |
| Unknown | STUDY ON THE EFFECTS OF PERIODONTAL TREATMENT ALONG WITH THE USE OF ANTIBIOTICS OVER HIGH SENSITIVE C-REACTIVE NCT01906450 | Universidad del Valle, Colombia | N/A |
| Completed | Chronic Periodontitis and Polycystic Ovary Syndrome NCT02954120 | Bezmialem Vakif University | — |
| Completed | Osteoprotegerin Before and After Periodontal Surgery NCT02160613 | Cairo University | N/A |
| Completed | Comparison of Autogenous Periosteal Pedicle Graft and Collagen Membrane in Management of Periodontal Intrabony NCT02248103 | Cairo University | N/A |
| Completed | Diode Laser Therapy As An Adjunct To Scaling And Root Planing NCT03028727 | KLE Society's Institute of Dental Sciences | N/A |
| Completed | Clinical and Microbiological Efficacy of Systemic Ayurvedic Immunomodulator Septilin in the Treatment of Chron NCT02013323 | Government Dental College and Research Institute, Bangalore | Phase 2 |
| Unknown | Clinical Trial of PeriZone PerioPatch in Subjects With Chronic Periodontitis NCT01808703 | MIS Implant Technologies, Ltd | N/A |
| Completed | PRF Growth Factors Levels in Diabetic Patients With Chronic Periodontitis NCT02304497 | Bulent Ecevit University | — |
| Completed | Periodontal Treatment in Non-controlled Type 2 Diabetes Mellitus Patients. Clinical Trial NCT01904422 | Universidad de los Andes, Chile | N/A |
| Completed | Gene Expression Profiles in Chronic Periodontitis NCT02467283 | Kocaeli University | — |
| Completed | 1.2% Atorvastatin and 1.2% Simvastatin in Treatment of Chronic Periodontitis NCT02060032 | Government Dental College and Research Institute, Bangalore | Phase 2 / Phase 3 |
| Completed | Clinical Efficacy Of 810 Nanometer Diode Laser As An Adjunct To Mechanical Periodontal Treatment Of Residual P NCT02531555 | Marmara University | N/A |
| Unknown | Clinical and Microbiological Evaluation of Periodontal Treatment of Diabetic Patients: A Longitudinal Study NCT02643771 | Eduardo Aleixo Figueira | Phase 2 |
| Completed | Evaluation of Techniques for Scaling and Root Planing and One Stage Full Mouth Disinfection NCT02126267 | Centro Universitario de Lavras | N/A |
| Completed | Applied The Platelet Rich Fibrin in Chronic Periodontitis NCT02594605 | Ataturk University | Phase 2 |
| Unknown | Propolis In The Treatment Of Periodontitis NCT01943877 | Rajarajeswari Dental College & Hospital | N/A |
| Completed | Impact of Periodontal Intervention on Vascular Dysfunction NCT01917292 | First Affiliated Hospital, Sun Yat-Sen University | Phase 3 |
| Completed | Benefits of Platelet Rich Fibrin In Mandibular Molar Furcation Defects NCT02430519 | Dr.Syed Asimuddin | N/A |
| Completed | Omega-3 Fatty Acids in Chronic Periodontitis. NCT01997853 | Tatyasaheb Kore Dental College | Phase 4 |
| Completed | Use of the Ozone in Periodontal Treatment NCT03444350 | Çanakkale Onsekiz Mart University | N/A |
| Completed | The Effect of Azithromycin in the Treatment of Chronic Periodontitis NCT01921738 | Isfahan University of Medical Sciences | Phase 2 |
| Completed | Clinical, Anti-Inflammatory And Anti-Infective Properties Of Amniotic Membranes Used For Guided Tissue Regener NCT02033226 | SVS Institute of Dental Sciences | Phase 3 |
| Completed | Role of Leukotriene Receptor Antagonists in Treatment of Chronic Periodontitis NCT02014532 | Tatyasaheb Kore Dental College | Phase 4 |
| Completed | Role of Herbal Immunomodulators in the Treatment of Chronic Periodontitis NCT01997814 | Tatyasaheb Kore Dental College | Phase 4 |
| Completed | Role of Infected Blood Dendritic Cells in Heart Disease Risk NCT01568944 | Augusta University | N/A |
| Terminated | Glucosamine Periodontal Adjunctive Therapy NCT02214095 | Ain Shams University | EARLY_Phase 1 |
| Completed | Comparison of PRP & DFDBA vs. DFDBA in Intrabony Periodontal Defects NCT05886699 | Government Dental College and Hospital, India | N/A |
| Unknown | White Blood Cell Signaling and Defense Mechanisms in Patients With Diabetes Mellitus Type 2 and Periodontitis NCT01848379 | Zentrum fuer Zahn-, Mund- und Kieferheilkunde | N/A |
| Completed | A Clinical Trial of YH14642 in Patients With Chronic Periodontal Disease NCT01499225 | Yuhan Corporation | Phase 2 |
| Completed | Effect of Nonsurgical Periodontal Therapy Verses Oral Hygiene Instructions on Patients With Chronic Periodonti NCT02208739 | University of Malaya | N/A |
| Unknown | Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy NCT01532674 | Francisco Alpiste Illueca | Phase 4 |
| Completed | Efficacy of INERSAN in Patients With Chronic Periodontitis as Adjunctive to Full Mouth Disinfection NCT01438333 | University of L'Aquila | N/A |
| Completed | Analysis of Neutrophil Response in Chronic Periodontitis NCT01233765 | Birmingham Community Healthcare NHS | — |
| Completed | MTZ Plus AMX in the Treatment of Smokers and Non-smokers NCT01837199 | University of Guarulhos | Phase 4 |
| Unknown | Dose and Duration of Metronidazole and Amoxicillin for Treatment of Chronic Periodontitis NCT02735395 | University of Guarulhos | Phase 4 |
| Completed | Probiotics Effects to Initial Periodontal Treatment NCT05408364 | Marmara University | N/A |
| Completed | Plaque Formation Rate and Toothpaste NCT02697539 | University Hospital Muenster | N/A |
| Completed | Effect of Root Planing on Surface Topography. NCT01945632 | Universidad de Granada | N/A |
| Completed | Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis NCT01246596 | Centre Hospitalier Universitaire de Nice | N/A |
| Completed | Clinical and Radiological Effect Of Platelet Rich Fibrin on the Healing of Periodontal Intrabony Periodontal D NCT02836314 | Baskent University | N/A |
| Completed | Study to Compare Laser Assisted New Attachment Procedure (LANAP) to Traditional Treatments of Chronic Periodon NCT01282229 | Institute for Advanced Laser Dentistry | N/A |
| Completed | Treatment of Intrabony Periodontal Defects With Enamel Matrix Derivatives and Autogenous Bone Graft NCT02218515 | Haner Direskeneli, Prof | Phase 4 |
| Unknown | Adjunctive Photodynamic Therapy in the Treatment of Chronic Periodontitis NCT01330082 | Tehran University of Medical Sciences | Phase 2 / Phase 3 |
| Completed | Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Pr NCT01195493 | University Hospital, Ghent | Phase 4 |
| Completed | Adjunctive Photodynamic Therapy in Treatment of Chronic Periodontitis NCT01034501 | University of Sao Paulo | Phase 4 |
| Completed | Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to NCT01211223 | University of Chile | Phase 4 |
| Completed | Short-term Changes on C-Reactive Protein (CRP) Levels After Non-surgical Periodontal Treatment NCT01433744 | State University of Maringá | N/A |
| Unknown | Periodontal Ligament Stem Cell Implantation in the Treatment of Periodontitis NCT01082822 | Air Force Military Medical University, China | Phase 1 / Phase 2 |
| Completed | Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System NCT02190773 | Hacettepe University | — |
| Completed | The Periodontal Disease and Diabetes Mellitus Interrelationship Among Adult Malaysians NCT01951547 | University of Malaya | N/A |
| Completed | Diabetes and Periodontal Therapy Trial NCT00997178 | Stony Brook University | Phase 3 |
| Completed | Dietary Supplementation With Low-Dose Omega-3 Reduces Salivary TNF-α Levels in Patients With Chronic Periodont NCT02719587 | İlker KESKINER | EARLY_Phase 1 |
| Completed | 1% Alendronate Gel in Treatment of Chronic Periodontitis Among Smokers NCT02168543 | Government Dental College and Research Institute, Bangalore | Phase 2 |
| Completed | Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole on Patients With Chronic Periodontitis NCT00805558 | Facultad Nacional de Salud Publica | Phase 4 |
| Completed | Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing NCT02197260 | University of Geneva, Switzerland | Phase 4 |
| Completed | Treatment of Periodontitis Using Er:YAG Laser vs. Conventional Treatment Modalities NCT00669253 | University Hospital, Ghent | N/A |
| Completed | Photodynamic Therapy Associated With Full-mouth Ultrasonic Debridement in the Treatment of Severe Chronic Peri NCT01535690 | Escola Bahiana de Medicina e Saude Publica | N/A |
| Completed | Methodological Evaluation of Gingival Crevicular Fluid Volume and Elastase Level NCT02676362 | Baskent University | N/A |
| Completed | The Effect Of Glycemic Control On Malondialdehyde, Glutathione Peroxidase, Glutathione And Paraoxonase NCT01467674 | Suleyman Demirel University | — |
| Completed | Full-mouth Periodontal Debridement and Metronidazole Gel in Patients With Chronic Periodontitis NCT01938183 | University of Campinas, Brazil | Phase 2 |
| Completed | Full-mouth Treatment Approaches in Severe Chronic Periodontitis. NCT04038801 | Aydin Adnan Menderes University | N/A |
| Completed | The Effect of Periodontal Therapy in Chronic Periodontitis Patients With and Without Acute Myocardial Infarcti NCT03005886 | Gazi University | N/A |
| Completed | Randomized Clinical Trial of Enamel Matrix Derivative: Radiographic Analysis NCT02195765 | University of Sao Paulo | N/A |