NCT02503046

Estimation of Pentraxin3 and PGingivalis Levels in Patients With Knee Joint and Gum Diseases

Estimation of Pentraxin 3 and Porphyromonas Gingivalis Levels in Patients With Rheumatoid Arthritis and Periodontitis- An Observational Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 90 (actual)
• Sponsor: Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre · Academic / Other
• Sex: All
• Age: 30 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Periodontitis and Rhematoid arthritis are chronic inflammatory diseases which share common risk factors The purpose of this study is to determine if Pentraxin 3 and Porphyromonas Gingivalis levels play an important role in the progression of both the diseases.

Detailed description

Periodontal disease progression might play a significant role in the severity and outcome of systemic diseases like rheumatoid arthritis. Pentraxin3 is a newly discovered inflammatory biomarker. It is a member of acute phase proteins and it has been observed from previous studies that plasma pentraxin3 levels have increased with increasing severity of cardiac and renal problems. Porphyromonas gingivalis proteinase is responsible for the epitope development in RF-Fc region These proteinases are important virulence factors which lead to degradation of host tissue. Porphyromonas gingivalis is also a key periodonto pathogen. Thus the aim of this study is to compare the plasma pentraxin3 and p.gingivalis levels in patients with periodontitis and rheumatoid arthritis.

Conditions

• Rheumatoid Arthritis
• Chronic Periodontitis

Interventions

Type	Name	Description
OTHER	Estimation of Pentraxin3	5ml of blood to be collected from each subject, centrifuged, to separate the plasma for estimation of Pentraxin3 (Quantikine ELISA)
GENETIC	Estimation of P.Gingivalis levels	Pooled plaque sample will be collected and sent for DNA Extraction by PCR for assessment of levels of PGingivalis

Timeline

• Start date: 2015-02-01
• Primary completion: 2015-11-01
• Completion: 2015-12-01
• First posted: 2015-07-20
• Last updated: 2016-08-29

Locations

1 site across 1 country: India