NCT01568944

Role of Infected Blood Dendritic Cells in Heart Disease Risk

Peripheral Blood Dendritic Cells and Periodontitis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Augusta University · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Accepted

Summary

The investigators hypothesize that blood dendritic cells harbor pathogens from the oral cavity in chronic periodontitis and disseminate these pathogens to atherosclerotic plaques.

Detailed description

To address this hypothesis, a clinical study in humans with moderate to severe chronic periodontitis has been designed. This is an interventional study involving scaling and root planing and two arms: 1. treatment with PO amoxocillin/metronidazole plus chlorhexidine oral rinse; 2. no antibiotics or oral rinse. It is expected that the antibiotics plus chlorhexidine will prevent the dendritic cell response to infection (bacteremia) elicited by scaling and root planing.

Conditions

• Chronic Periodontitis

Interventions

Type	Name	Description
DRUG	Oral Antibiotic and Oral Rinse	PO Amoxicillin in 500 mg / Metronidazole 250 mg of each TID for 8 days plus 2 ounces of 0.12% chlorhexidine mouthrinse used BID
PROCEDURE	Standard Treatment	Full mouth scaling and root planing using hand instrumentation (curettes) and ultrasonic scalers

Timeline

• Start date: 2012-03-01
• Primary completion: 2014-09-01
• Completion: 2014-09-01
• First posted: 2012-04-02
• Last updated: 2020-05-12
• Results posted: 2020-05-12

Locations

1 site across 1 country: United States