NCT02190773

Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System

Effect of Surgical Periodontal Therapy on the RANKL/OPG System : Do we Need Osteo-immune Modulation Targeting RANKL?

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 65 (actual)
• Sponsor: Hacettepe University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

In the present clinical study including chronic, aggressive periodontitis and healthy individuals, the investigators aimed to determine the RANKL, osteoprotegrin (OPG), Interleukin-1 (IL-1β), IL-10, IL-1β levels in gingival crevicular fluid(GCF) before and after surgical periodontal treatment and search out the relationship of clinical parameters with these cytokine levels.

Conditions

• Chronic Periodontitis
• Aggressive Periodontitis
• RANKL/OPG Ratio
• Gingival Crevicular Fluid

Timeline

• Start date: 2010-01-01
• Primary completion: 2013-04-01
• Completion: 2013-04-01
• First posted: 2014-07-15
• Last updated: 2014-07-15

Locations

1 site across 1 country: Turkey (Türkiye)