| Recruiting | Single-cell and Spatial Transcriptomic Profiling of Gingival Tissues in Aggressive and Chronic Periodontitis: NCT07487272 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Recruiting | The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive Periodo NCT05043935 | Kafrelsheikh University | N/A |
| Completed | Effect of Non Surgical Periodontal Therapy on Inflammatory Markers in Chronic Periodontitis Patients NCT05295576 | Future University in Egypt | — |
| Completed | Non Surgical Periodontal Treatment Effect on Il-17 and Il-18 in Aggressive Periodontitis NCT05297084 | Future University in Egypt | — |
| Completed | Concentrated Growth Factors in Treatment of Intrabony Defects in Localized Aggressive Periodontitis NCT05001919 | Tanta University | Phase 1 / Phase 2 |
| Unknown | Transplantation of Bone Marrow Mesenchymal Stromal Cells for Periodontal Regeneration NCT05975892 | Instituto Venezolano de Investigaciones Cientificas | Phase 1 / Phase 2 |
| Completed | Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis NCT03093246 | Universidade Estadual Paulista Júlio de Mesquita Filho | Phase 2 / Phase 3 |
| Completed | Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Period NCT03093207 | Universidade Estadual Paulista Júlio de Mesquita Filho | Phase 2 / Phase 3 |
| Unknown | Influence of Smoking on Clinical, Microbiological and Immunologic Parameters in Patients With Aggressive Perio NCT04051255 | University of Campinas, Brazil | N/A |
| Completed | Interaction Between Immune Cells and Bacteria Associated With Periodontitis NCT03225950 | University of Copenhagen | — |
| Completed | Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodont NCT03025204 | University of Campinas, Brazil | Phase 4 |
| Completed | Estimation of Pentrexin-3 Levels in GCF and Saliva of Patients With Periodontal Disease NCT03128502 | Cairo University | — |
| Unknown | Efficacy of Three Antibiotic Protocols for Aggressive Periodontitis Treatment NCT02839421 | Facultad Nacional de Salud Publica | Phase 4 |
| Recruiting | B Cell Functions in Periodontitis NCT02833285 | University Hospital, Brest | — |
| Completed | Smoking Influence on Apoptosis in Periodontitis NCT02111005 | Damascus University | — |
| Completed | Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis NCT02969928 | Universidade Estadual Paulista Júlio de Mesquita Filho | Phase 2 / Phase 3 |
| Completed | Antimicrobial Photodynamic Therapy in Treatment of Aggressive Periodontitis (Stage III, Grade C Periodontitis) NCT05655338 | University of Ljubljana | N/A |
| Completed | IL-34 Levels in Various Types of Periodontitis NCT04223869 | Bulent Ecevit University | N/A |
| Completed | Nitro-oxidative Stress in Periodontitis NCT02127203 | Damascus University | — |
| Completed | Clarithromycin as Adjuvant to Periodontal Debridement NCT02829983 | Universidade Estadual Paulista Júlio de Mesquita Filho | N/A |
| Completed | Doxycycline in the Treatment of Aggressive Periodontitis NCT03727620 | Mohammed V Souissi University | Phase 1 / Phase 2 |
| Completed | Effects of Er,Cr:YSGG, Diode Lasers on GCF Cytokines Levels NCT03034824 | Yuzuncu Yil University | N/A |
| Terminated | Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis NCT01993368 | Centre Hospitalier Universitaire de Nice | N/A |
| Completed | Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy NCT02049008 | University of Sao Paulo | Phase 4 |
| Completed | Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients NCT02466646 | Marmara University | Phase 4 |
| Unknown | The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis NCT01510808 | Hadassah Medical Organization | — |
| Completed | Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis NCT02125812 | Facultad Nacional de Salud Publica | Phase 4 |
| Completed | Alternative Antibiotic Regime in the Treatment of GAgP NCT02223702 | Kocaeli University | Phase 4 |
| Completed | Gingival Crevicular Fluid Levels Of Monocyte Chemoattractant Protein-1 NCT02927704 | Abant Izzet Baysal University | — |
| Completed | Frequency Of MCP-1 And CCR2 Gene Polymorphisms And Its Effect On Gene Expression In Patients With AgP NCT02817568 | Abant Izzet Baysal University | — |
| Completed | Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis NCT01246596 | Centre Hospitalier Universitaire de Nice | N/A |
| Completed | Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients NCT02282800 | Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre | — |
| Completed | Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System NCT02190773 | Hacettepe University | — |
| Completed | Mechanisms and Treatment Response of Aggressive Periodontitis in Children NCT01330719 | University of Florida | N/A |