NCT05043935

The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive Periodontitis

The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Treatment of Aggressive Periodontitis Patients: A Randomized Controlled Clinical Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Kafrelsheikh University · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Antimicrobial photodynamic therapy (aPDT) is associated with photosensitizing agents which promote the generation of free radicals and singlet oxygen, which are cytotoxic to certain bacteria. Leukocyte and platelet-rich fibrin (L-PRF) has been used extensively in the treatment of intrabony defects and achieved excellent results. It acts as an immune regulation node with inflammation control abilities, including a slow continuous release of growth factors which stimulates periodontal regeneration. The aim of this study is to evaluate the adjunctive effects of aPDT with and without L-PRF in aggressive periodontitis patients.

Conditions

• L-PRF
• Photodynamic Therapy
• Aggressive Periodontitis

Interventions

Type	Name	Description
PROCEDURE	L-PRF with antimicrobial photodynamic therapy	Application of L-PRF with antimicrobial photodynamic therapy in the defect
PROCEDURE	antimicrobial photodynamic therapy without L-PRF	application of antimicrobial photodynamic therapy without L-PRF in the defect

Timeline

• Start date: 2021-11-22
• Primary completion: 2024-09-01
• Completion: 2024-10-01
• First posted: 2021-09-14
• Last updated: 2024-04-11

Locations

1 site across 1 country: Egypt