NCT02829983

Clarithromycin as Adjuvant to Periodontal Debridement

Clarithromycin as Adjuvant to Periodontal Debridement in the Treatment of Generalized Aggressive Periodontitis: Randomized Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Universidade Estadual Paulista Júlio de Mesquita Filho · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

To assess the periodontal clinical response and the possible adverse effects of the clarithromycin combined to periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis.

Detailed description

To assess the periodontal clinical response and the possible adverse effects of the clarithromycin combined to periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis.Forty patients were select and randomly assigned into two groups: Group clarithromycin with 20 subjects that received one-stage full-mouth ultrasonic debridement (FMUD) associated with clarithromycin (500 mg - 12/12 hours) for 3 days; group placebo with 20 subjects that received FMUD associated with placebo. Probing depth (PD), gain in clinical attachment level (CAL) and bleeding on probing (BOP) were evaluated at baseline, 3 and 6 months post- operatively.

Conditions

• Aggressive Periodontitis

Interventions

Type	Name	Description
DRUG	Clarithromycin	Use of 500mg of Clarithromycin twice a day for 3 days
DRUG	Placebo	Use of placebo tablets twice a day for 3 days.
OTHER	One-stage full-mouth ultrasonic debridement (FMUD)	One session of Periodontal debridement using ultrasonic device.

Timeline

• Start date: 2014-03-01
• Primary completion: 2015-08-01
• Completion: 2015-11-01
• First posted: 2016-07-12
• Last updated: 2017-11-21
• Results posted: 2017-10-17