NCT02467283

Gene Expression Profiles in Chronic Periodontitis

Gene Expression Profiles in Chronic Periodontitis: A Gene Network-based Microarray Analysis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 46 (actual)
• Sponsor: Kocaeli University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Current concepts of the causes of periodontitis implicate a bacterial infection as the primary cause of the disease. Several bacterial species residing in a biofilm on tooth surfaces are closely associated with periodontitis. Chronic periodontitis (CP) is initiated and sustained by bacterial plaque, but host defense mechanisms play an integral role in its pathogenesis. Gene expression profiling is a powerful means of generating comprehensive genome-level data sets on diseases such as cancer, asthma, rheumatoid disorders and periodontitis, and provides significant insight information for these diseases. Gene expression profiling may provide an evidence for involving genes in the pathogenesis of CP and generate further information other than clinical signs and symptoms of CP. The aim of this study was to identify gene-expression patterns of patients with chronic periodontitis by whole-transcriptome gene-expression analyses.

Conditions

• Chronic Periodontitis

Interventions

Type	Name	Description
GENETIC	Genom-based whole-genome transcriptomic	Gene expression profiling is a powerful means of generating comprehensive genome-level data sets.

Timeline

• Start date: 2013-02-01
• Primary completion: 2015-08-01
• Completion: 2017-05-01
• First posted: 2015-06-10
• Last updated: 2018-02-12