NCT03553095

Comparing Inflammatory Markers in Patients With and Without Depression With Chronic Periodontitis

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 92 (actual)
• Sponsor: University of Alabama at Birmingham · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Accepted

Summary

This study will evaluate whether use of antidepressants can reduce gingival inflammation in patients with periodontal (gum) disease.

Detailed description

The primary purpose of this study is to evaluate whether use of antidepressants can reduce gingival inflammation in patients with periodontal (gum) disease. This study will also investigate the link between oral and systemic inflammation in patients diagnosed with depression and periodontal disease. Researcher will collect gingival crevicular fluid, plaque, tissue and blood serum samples to evaluate the link between these two diseases. The collection of gingival crevicular fluid, plaque and blood serum is relatively non-invasive, elicits minimal discomfort and does not require use of any anesthesia. The soft tissue sample will be collected as part of an otherwise planned periodontal surgical procedure under local anesthesia. In periodontal therapy (surgical procedures i.e. gum surgery, tooth extraction and or dental implant surgery) there is enough availability of remnant tissue for the collection of samples, which is otherwise discarded.

Conditions

• Chronic Periodontitis
• Depression

Interventions

Type	Name	Description
PROCEDURE	Periodontal Surgery	Samples will be collected from patient in need of periodontal therapy (surgical procedures i.e. gum surgery, tooth extraction and or dental implant surgery). As standard during this procedures remnant tissue is otherwise discarded.

Timeline

• Start date: 2018-07-12
• Primary completion: 2019-12-30
• Completion: 2026-12-30
• First posted: 2018-06-12
• Last updated: 2025-12-12

Locations

1 site across 1 country: United States