NCT02898675

Advantages of Autologous Platelet-Rich Fibrin Membrane on Growth Factor Levels and Periodontal Healing

Investigation of the Contributions of Platelet Rich Fibrin Combined With Open Flap Debridement on Periodontal Healing

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (actual)
• Sponsor: Ataturk University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Platelet rich fibrin is a second generation platelet concentration which contains various growth factors. The aim of this study is to evaluate the clinical and biochemical efficacy of PRF in subjects of chronic periodontitis in the operation of conventional periodontal flap.

Detailed description

PRF was developed in 2001 by Choukroun in France, it was the second generation fibrin adhesive, and was used to accelerate the soft and hard tissue healing. Many studies have shown beneficial effects of PRF on osteoconductive filler material in sinus lift operations, treatment of periodontal sulcus defect and treatment of furcation defects. Also PRF contains many growth factors. PRF accelerates periodontal regeneration through the gradually excreted growth factors and contributes to the bone regeneration. In this study, the investigators evaluated the effect of PRF on growth factors and its contribution to periodontal regeneration in subjects with chronic periodontitis.

Conditions

• Chronic Periodontitis

Interventions

Type	Name	Description
DEVICE	Platelet rich fibrine	Platelet rich fibrin increases the growth factors. So it was applied for treatment of periodontal bone loss.
DEVICE	Open Flap Debridement	Only open flap debridement treatment the bone loss limitedly

Timeline

• Start date: 2014-10-01
• Primary completion: 2015-06-01
• Completion: 2016-05-01
• First posted: 2016-09-13
• Last updated: 2016-09-13