NCT03043066

Serum TRAP-5b Levels in Patients With Generalized Chronic Periodontitis

The Effect of Non-surgical Periodontal Therapy With or Without Systemic Administration of Amoxicillin and Metronidazole on Serum Levels of TRAP-5b in Patients With Generalized Chronic Periodontitis - A Comparative Clinical Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Meenakshi Ammal Dental College and Hospital · Academic / Other
• Sex: All
• Age: 30 Years – 45 Years
• Healthy volunteers: Accepted

Summary

To compare the effect of non-surgical periodontal therapy with or without systemic administration of amoxicillin and metronidazole on the concentration of serum levels of TRAP-5b in patients with generalized chronic periodontitis.

Detailed description

30 Chronic periodontitis subjects were divided into two groups- group A underwent scaling and root planing and group B underwent scaling and root planing with systemic administration of amoxicillin of 500 mg and metronidazole of 400 mg thrice daily for 7 days. Periodontal parameters probing pocket depth and clinical attachment level were measured at baseline and at 3rd month. Serum TRAP-5b levels were also measured at baseline, 1 month and at 3rd month.

Conditions

• Chronic Periodontitis

Interventions

Type	Name	Description
PROCEDURE	Scaling and root planing	subjects underwent full mouth supragingival and subgingival scaling
DRUG	scaling and root planing along with antibiotic intervention	subjects underwent full mouth supragingival and subgingival scaling along with antibiotic intervention of amoxicillin of 500 mg and metronidazole of 400 mg thrice daily for 7 days

Timeline

• Start date: 2016-03-01
• Primary completion: 2016-07-31
• Completion: 2016-10-01
• First posted: 2017-02-03
• Last updated: 2017-02-03