| Recruiting | Assessment of HPHC Exposure in Smokers Switching to THS/TP18 With Different Device Variants Smoking | N/A | 2026-02-19 |
| Active Not Recruiting | Pharmacokinetics and Pharmacodynamics of THS With LEVIA Compared to THS With TEREA and to Cigarettes Nicotine | N/A | 2026-02-01 |
| Active Not Recruiting | Exploratory Randomized, Controlled, Dose-response Study on the Impact of Nicotine From Five Variants of a Nico Attention | N/A | 2025-10-28 |
| Active Not Recruiting | Nicotine Pharmacokinetics and Pharmacodynamics of Two Variants of VM 1.0 Compared to Cigarettes in Adult Curre Nicotine | N/A | 2025-07-17 |
| Recruiting | Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS COPD, Smoking, Tobacco Use | N/A | 2025-04-02 |
| Completed | Pharmacokinetics and Comparative Bioavailability of Nicotine From Two Variants of NP2, NP2-4mg and NP2-6mg, Co Tobacco Use | N/A | 2023-10-20 |
| Withdrawn | Effect of Switching From Cigarette Smoking to THS on Systemic Endothelial Function in Subjects With Establishe Cardiovascular Diseases, Smoking, Tobacco Use | N/A | 2023-03-15 |
| Completed | Nicotine Pharmacokinetics of THS Single Use of a Regular or a Menthol Stick Compared to CIG Smoking, Tobacco | N/A | 2023-02-16 |
| Terminated | Effect of Switching From Cigarette Smoking to THS on Disease Progression in Mild to Moderate COPD Subjects Wit COPD, Smoking, Tobacco Use | N/A | 2022-12-16 |
| Completed | Reduced Exposure to HPHC in Smokers Switching From Cigarettes to Different Versions of THS Smoking, Tobacco Smoking, Tobacco Use | N/A | 2022-11-04 |
| Completed | Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoki Nicotine, Vaping, Nicotine Vaping | N/A | 2022-07-15 |
| Completed | Reduction of Exposure, Inflammation, and Oxidative Stress Following At Least 2 Years of Switching to THS Use C Inflammation, Oxidative Stress, Smoking | — | 2022-06-13 |
| Completed | Nicotine Pharmacokinetics Following Use of the P4M3 Gen 2.0 E-Cigarette Compared to Smoking Cigarettes Nicotine Vaping, Nicotine, Vaping | N/A | 2022-04-28 |
| Completed | Nicotine Pharmacokinetics and Subjective Effects of Nicotine Pouch 1.0 Compared to Velo® Ice Cool and Zyn® Coo Smoking, Nicotine | N/A | 2022-03-15 |
| Completed | Product Use and Adaptation, Safety and Tolerability of P3P in Adult Healthy Smokers Switching to it Pharmacokinetics | N/A | 2019-04-23 |
| Completed | Effect of Switching From Cigarette Smoking to IQOS on Exercise Capacity Smoking, Exercise Capacity | N/A | 2019-02-01 |
| Completed | Comparison of Abdominal Aortic Aneurysm Growth in Adult Smoking Patients Who Either Switch to IQOS, Continue S Smoking, Abdominal Aortic Aneurysm, IQOS Use | N/A | 2018-10-03 |
| Terminated | Cross-Sectional Survey on the Use of Tobacco Products - Italy Tobacco Use | — | 2018-03-20 |
| Terminated | Cross-Sectional Survey on the Use of Tobacco Products - Germany Tobacco Use | — | 2018-03-12 |
| Terminated | Cross-Sectional Survey on the Use of Tobacco Products - London (UK) Tobacco Use | — | 2018-03-08 |
| Completed | Real-Life Passive Exposure Assessment of IQOS Environmental Exposure | — | 2017-12-05 |
| Completed | Nicotine Pharmacokinetics and Pharmacodynamics, Safety and Tolerability of P3P Pharmacokinetics | N/A | 2017-11-07 |
| Completed | Effect of Switching From Cigarette Smoking to the Use of IQOS on Periodontitis Treatment Outcome Periodontal Diseases, Chronic Periodontitis, Periodontal Pocket | N/A | 2017-11-07 |
| Completed | Study to Investigate the Nicotine Pharmacokinetic Profiles and Pharmacodynamic Effects of P4M3 Variants Vaping, Nicotine Absorption | N/A | 2017-07-11 |
| Completed | Prefatory Study to Explore Changes in Nasal Mucociliary Clearance and to Standardize Nasal Scraping Procedure Smokers, Never Smokers | N/A | 2017-01-21 |
| Terminated | Japanese Post-Market Cohort Study Smoking, Tobacco Product | — | 2016-04-01 |
| Completed | Reduced Exposure Study Using the CHTP 1.2 With 5 Days in a Confinement Setting Followed by 85 Days in an Ambul Smoking | N/A | 2016-01-01 |
| Completed | User Acceptability of a Nicotine Lactate Delivery System (P3L) Smoking | N/A | 2015-11-01 |
| Completed | Nicotine Pharmacokinetic and Pharmacodynamics Profile, Safety and Tolerability of P3L Smoking | N/A | 2015-10-01 |
| Completed | A 26-week Extension of the ZRHR-ERS-09-US Study Evaluating Biological and Functional Changes in Healthy Smoker Smoking | N/A | 2015-09-30 |
| Completed | Reduced Exposure Study Using CHTP 1.0 During 5 Days in Confinement. Smoking | N/A | 2015-07-01 |
| Completed | A Smoking Cessation Study to Understand the Biological and Functional Changes After One Year of Smoking Cessat Cigarette Smoking | — | 2015-05-05 |
| Completed | Nicotine Pharmacokinetic Profile of the CHTP 1.1 M Smoking | N/A | 2015-05-01 |
| Completed | Evaluation of Biological and Functional Changes in Healthy Smokers After Switching to THS 2.2 for 26 Weeks Smoking | N/A | 2015-03-12 |
| Completed | Reduced Exposure Study Using THS 2.2 Menthol With 5 Days in a Confinement Setting Followed by 86 Days in an Am Smoking | N/A | 2013-12-01 |
| Completed | Nicotine Pharmacokinetic Profile and Safety of the Tobacco Heating System 2.2 (THS 2.2) Smoking | N/A | 2013-11-01 |
| Completed | Nicotine Pharmacokinetic Profile and Safety of the Tobacco Heating System 2.2 Menthol (THS 2.2 Menthol) Smoking | N/A | 2013-10-01 |
| Completed | Reduced Exposure Study Using THS 2.2 Menthol With 5 Days in a Confinement Setting and 85 Days in an Ambulatory Smoking | N/A | 2013-08-01 |
| Completed | Nicotine Pharmacokinetic Profile and Safety of the Tobacco Heating System 2.2 Menthol (THS 2.2 Menthol). Smoking | N/A | 2013-08-01 |
| Completed | Nicotine Pharmacokinetic Profile and Safety of the Tobacco Heating System 2.2 (THS 2.2) Smoking | N/A | 2013-07-01 |
| Completed | Reduced Exposure Study in Smokers Using the Tobacco Heating System 2.2 (THS 2.2) for 5 Days in a Confinement S Smoking | N/A | 2013-07-01 |
| Completed | Reduced Exposure Study in Smokers Using THS 2.2 With 5 Days in a Confinement Setting. Smoking | N/A | 2013-06-01 |
| Completed | Exploratory THS 2.1 Biomarkers of Exposure Study Smoking | N/A | 2012-06-01 |
| Completed | Exploratory THS 2.1 Nicotine Pharmacokinetics and Safety Study Smoking | N/A | 2012-05-01 |
| Completed | Chronic Obstructive Pulmonary Disease (COPD) Biomarker Identification Study COPD | — | 2011-07-01 |
| Completed | Smoking Research Study Smoking, Non-smoking | N/A | 2011-07-01 |
| Completed | Investigate the Exposure to Selected Smoke Constituents in Smokers Switching to Distillation Based Smoking Art Smoking | N/A | 2008-11-01 |
| Completed | Determination of Biomarkers of Exposure and Biomarkers of Potential Harm in Asian Adult Cigarette Smokers Smoking, Healthy | — | 2007-07-01 |
| Completed | European Exposure Study Smoking | — | 2005-04-01 |