NCT07408180

Exploratory Randomized, Controlled, Dose-response Study on the Impact of Nicotine From Five Variants of a Nicotine Tablet (NICOTINE TABLET) on Attention

Impact of Nicotine From Five Variants of a Nicotine Tablet on Attention in Adult Users of Nicotine Pouches: An Exploratory, Randomized, Controlled, Double-blind, Crossover Study

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Philip Morris Products S.A. · Industry
• Sex: All
• Age: 19 Years – 60 Years
• Healthy volunteers: Accepted

Summary

This study aims to provide initial insights into the impact of orally delivered nicotine on attentional performance in adult occasional users of nicotine pouches. Nicotine will be administered via a dissolvable tablet for approximately 10 minutes. The main objective of this exploratory study is to characterize the effect of nicotine on attentional performance, using metrics derived from Continuous Performance Test (CPT). Additionally, a second CPT assessment will be conducted two hours after the first administration to explore the potential sustained effects of nicotine on attention as an exploratory objective.

Conditions

• Attention

Interventions

Type	Name	Description
OTHER	NICOTINE TABLET-0mg	NICOTINE TABLET (nicotine content 0mg; Mint flavor)
OTHER	NICOTINE TABLET-0.5mg	NICOTINE TABLET (nicotine content 0.5mg; Mint flavor)
OTHER	NICOTINE TABLET-1.0mg	NICOTINE TABLET (nicotine content 1.0mg; Mint flavor)
OTHER	NICOTINE TABLET-1.5mg	NICOTINE TABLET (nicotine content 1.5mg; Mint flavor)
OTHER	NICOTINE TABLET-2.0mg	NICOTINE TABLET (nicotine content 2.0mg; Mint flavor)

Timeline

• Start date: 2025-10-28
• Primary completion: 2026-03-16
• Completion: 2026-04-23
• First posted: 2026-02-13
• Last updated: 2026-02-18

Locations

1 site across 1 country: Sweden