NCT07108790

Bovine Bone With or Without Concentrated Growth Factor in the Treatment of Chronic Periodontitis

Comparative Study Between Bovine Bone With or Without Concentrated Growth Factor in the Treatment of Chronic Periodontitis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Tanta University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to compare bovine bone with or without concentrated growth factor in the treatment of chronic periodontitis.

Detailed description

Periodontitis is an infection-driven inflammatory disease resulting from dental plaque accumulation at the gingival margin, triggering an inflammatory response that leads to microbial alterations and may have severe consequences for the periodontium of susceptible individuals. The xenograft most commonly used in periodontal regeneration procedures is the deproteinized bovine or equine bone mineral. Platelets are known to play a significant role in guided tissue regeneration (GTR) by releasing several growth factors, such as platelet-derived growth factor (PDGF), and plasma rich in growth factors (PRGF), which are present in platelet-rich plasma (PRP), a first-generation platelet concentrate. Platelet-rich fibrin (PRF) and concentrated growth factors (CGF) are considered the second generation of platelet concentrate.

Conditions

• Bovine Bone
• Concentrated Growth Factor
• Chronic Periodontitis

Interventions

Type	Name	Description
OTHER	Concentrated growth factors, collagen membrane and xenograft bone graft	Ten sites were treated by concentrated growth factors (CGF), collagen membrane, and xenograft bone graft.
OTHER	Collagen membrane and xenograft bone graft	Ten sites were treated with a collagen membrane and a xenograft bone graft.

Timeline

• Start date: 2022-03-01
• Primary completion: 2025-01-01
• Completion: 2025-01-01
• First posted: 2025-08-07
• Last updated: 2025-08-07

Locations

1 site across 1 country: Egypt