NCT02719587

Dietary Supplementation With Low-Dose Omega-3 Reduces Salivary TNF-α Levels in Patients With Chronic Periodontitis

Dietary Supplementation With Low-Dose Omega-3 Fatty Acids Reduces Salivary TNF-α Levels in Patients With Chronic Periodontitis

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: İlker KESKINER · Academic / Other
• Sex: All
• Age: 30 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The investigators primary objective in this clinical intervention study, therefore, was to explore the impact of omega-3 PUFAs in conjunction with scaling and root planing on salivary markers (in patients with chronic periodontitis.

Detailed description

Thirty systemically healthy subjects with chronic periodontitis were enrolled and randomly allocated into two groups. The control group (n=15) was treated with scaling and root planing (SRP)+placebo whereas the test group (n=15) was treated with SRP and dietary supplementation of low-dose omega-3 PUFAs (6.25 mg EPA and 19.19 mg DHA). Clinical parameters were taken at baseline, 1, 3 and 6 months following therapy. Saliva samples were obtained at the same time intervals and analyzed for tumor necrosis factor-α (TNF-α) and superoxide dismutase (SOD).

Conditions

• Chronic Periodontitis

Interventions

Type	Name	Description
PROCEDURE	Placebo	placebo drug identical except for the fish oil supplement, were only performed at baseline.
PROCEDURE	Omega-3	omega-3 PUFAs supplement, were only performed at baseline.
PROCEDURE	SRP	Instrumentation was performed until the root surface was considered smooth and clean, according to the operator's clinical judgement.

Timeline

• Start date: 2009-04-01
• Primary completion: 2009-12-01
• Completion: 2010-01-01
• First posted: 2016-03-25
• Last updated: 2016-03-25