NCT07468929

Serum Inflammatory Protein Concentration During Dental Treatment

Systemic Molecular Markers of Surgical Trauma in Periodontitis/Peri-implantitis Patients

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Ohio State University · Academic / Other
• Sex: All
• Age: 21 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to study the molecular markers of stress in blood samples from people who are having periodontal surgery. The main question it aims to answer are: * How do the levels of inflammatory molecules in the blood change during a periodontal surgery? * How are the levels of inflammatory molecules in a person having surgery different from the levels in a person having a nonsurgical procedure? * Participants will be people who are having a periodontal surgery or a nonsurgical periodontal treatment as part of their dental care. Participants will be asked to let the investigator take blood samples from them before, during, and after the procedure is being done. The blood will later be analyzed for substances in the blood that are associated with inflammation.

Detailed description

Periodontal disease is a chronic inflammatory disease and is associated with pro-inflammatory mediators such as increased levels of Tumor necrosis factor-alpha (TNF-a), Interleukin (IL)-17, IL-6, IL-1beta, and C-reactive protein (CRP) within gingival tissues as well as gingival crevicular fluid. IL-17 is a pro-inflammatory cytokine that promotes recruitment of neutrophil and stimulates host cells to produce other pro-inflammatory factors such as IL-1, IL-6, TNF-, and CRP that are related to the acute phase of vascular inflammation. There is evidence supporting increased levels of these mediators at diseased tooth site. Based on the severity of local periodontal inflammation, some increase in circulatory serum levels of these mediators is also expected. However, the information on how periodontal treatment performed around teeth may affect circulatory serum levels of these biologic markers is limited. Thus, this study aims to assess the acute and subacute molecular systemic effects of extensive (more than 3 adjacent teeth) periodontal/peri-implant surgery and compare them with the possible effects of non-surgical therapy (control) in patients treated for generalized form of the periodontitis

Conditions

• Periodontal Disease
• Periodontal Surgery

Interventions

Type	Name	Description
OTHER	Blood samples for inflammatory markers	Blood samples will be obtained before the start of the procedure, the midpoint of the procedure, and the end of the procedure.
PROCEDURE	periodontal surgery	Periodontal/peri-implant surgical interventions, with or without IV sedation, as based on treatment needs
PROCEDURE	Periodontal maintenance	Regular cleaning to maintain health after surgical treatment for periodontal disease
PROCEDURE	Non-surgical deep cleaning	Debridement under local anesthesia, as based on treatment needs

Timeline

• Start date: 2026-02-01
• Primary completion: 2027-02-01
• Completion: 2027-02-01
• First posted: 2026-03-13
• Last updated: 2026-03-16

Locations

1 site across 1 country: United States