NCT07213752

Diode Laser-Assisted Periodontal Therapy Enhances Clinical Outcomes for Deep Periodontal Pockets in Smokers

Diode Laser-Assisted Periodontal Therapy Enhances Clinical Outcomes for Deep Periodontal Pockets in Smokers: A Randomized Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 33 (actual)
• Sponsor: Selcuk University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study investigated the adjunctive effects of diode laser therapy in smokers with severe periodontitis. Thirty-three patients were randomized to non-surgical periodontal therapy (SRP) with or without diode laser. Clinical parameters and salivary oxidative stress markers (MDA, 8-OHdG) were assessed at baseline, 1, and 3 months. Both groups showed improvements, but SRP+DL resulted in significantly greater reductions in deep pockets, PISA, PESA, PI, and MDA at 3 months. These findings suggest that diode laser therapy may enhance conventional treatment by improving clinical outcomes and reducing oxidative stress in smokers with severe periodontitis.

Conditions

• Periodontitis
• Periodontitis Stage III
• Periodontal Disease
• Diode Laser Therapy
• Smoking
• Malondialdehyde

Interventions

Type	Name	Description
DEVICE	Diode Laser Application in Deep Periodontal Pockets	A 940 nm indium-gallium-aluminum-phosphate diode laser (Ezlase, Biolase, USA) with a 400 μm fiber was used in contact mode at 1.5 W, pulse 20/20 ms, 20 s/cm², power density 1.061 W/cm², and 15 J/cm² energy in deep periodontal pockets.
PROCEDURE	Professional Mechanical Plaque Removal	Professional mechanical removal of supragingival plaque and calculus
PROCEDURE	Scaling and Root Planing	Subgingival scaling and root planing

Timeline

• Start date: 2023-12-10
• Primary completion: 2025-01-21
• Completion: 2025-06-05
• First posted: 2025-10-09
• Last updated: 2025-10-09

Locations

1 site across 1 country: Turkey (Türkiye)

Regulatory

• FDA-regulated device study