| Not Yet Recruiting | Addressing Parental Tobacco Use in Somali Immigrant Families: Adapting an Evidence-Based Intervention in Prima NCT06839729 | University of Minnesota | Phase 1 |
| Enrolling By Invitation | Using Smartwatches to Monitor Smoking in Real-life Situations NCT07067151 | National Institute on Minority Health and Health Disparities (NIMHD) | — |
| Not Yet Recruiting | Functional Capacity, Subjective Dyspnea and Fatigue in Smokers NCT07520981 | Istinye University | — |
| Not Yet Recruiting | Project DEDUCE: Digital Envirotyping to Develop Understanding of Cigarette Smoking and the Environment NCT07089901 | Duke University | Phase 4 |
| Not Yet Recruiting | Pain and Smoking Study - Interactive Voice Response NCT06442514 | VA Office of Research and Development | N/A |
| Not Yet Recruiting | A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery Systems NCT07323563 | RAI Services Company | N/A |
| Recruiting | Comparison of the Effects of Different Chest Techniques on University Students With Smoking Addiction NCT07488741 | University of Yalova | N/A |
| Recruiting | Assessment of HPHC Exposure in Smokers Switching to THS/TP18 With Different Device Variants NCT07443631 | Philip Morris Products S.A. | N/A |
| Not Yet Recruiting | Abuse Liability for Eight Electronic Nicotine Products NCT07323511 | RAI Services Company | N/A |
| Enrolling By Invitation | Engaging Pharmacists to Advance Tobacco Treatment Service Delivery NCT07501624 | Medical University of South Carolina | N/A |
| Not Yet Recruiting | Impact of Daridorexant on Sleep, Daytime Alertness, and Smoking NCT07328594 | Legacy Health System | Phase 4 |
| Not Yet Recruiting | Abuse Liability for Four Heated Tobacco Product (HTP) Consumables and Two HTP Devices NCT07267195 | RAI Services Company | N/A |
| Recruiting | Association of Periodontal Status and Smoking With Salivary Inflammasome Markers NCT07312552 | Uskudar University | — |
| Recruiting | Abuse Liability for Five Modern Oral Nicotine Products NCT07132814 | RAI Services Company | N/A |
| Recruiting | Inspire HER: Inspiring the Heart and Emotions for Radical Health NCT06966258 | University of Alabama at Birmingham | N/A |
| Recruiting | A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse NCT07223840 | Eli Lilly and Company | Phase 2 |
| Completed | Tabata Exercise on Nitric Oxide Synthases and Maresin NCT07412639 | Ataturk University | N/A |
| Not Yet Recruiting | Using Digital Health Technology to Prevent Bullying and Cyberbullying Among Elementary School Students NCT06592872 | Christopher Williams | N/A |
| Recruiting | Technology Assisted Motivational Interviewing NCT06713603 | University of California, San Francisco | N/A |
| Terminated | A RCT to Determine the Effect of ENDS Flavor Availability on Abstinence Within Smokers NCT07172438 | RAI Services Company | N/A |
| Recruiting | Precision Treatment to Promote Smoking Cessation and Survival in Oncology Patients NCT07166120 | Washington University School of Medicine | N/A |
| Recruiting | Clinical Alternatives for Reducing Harm Using E-cigarettes NCT07039292 | Medical University of South Carolina | N/A |
| Recruiting | Specimen and Clinical Data Collection Plan for LDCT Screening Participants NCT07048236 | Chung Shan Medical University | — |
| Recruiting | Actívatexto: Advancing Smoking Cessation and Physical Activity Among Latinos NCT06926608 | University of Rochester | N/A |
| Completed | Determination of RNA/DNA Damage Associated With Oxidative Stress in Periodontitis Patients NCT07279896 | Zehra Hasgül | — |
| Recruiting | Combination of Acupuncture, Auricular Acupressure and Nicotine Replacement Therapy for Smoking Cessation NCT06931054 | The University of Hong Kong | N/A |
| Recruiting | Wearable Devices Empowering Active Health Initiatives for High-Risk Stroke Populations NCT06935513 | Affiliated Hospital of Nantong University | N/A |
| Recruiting | Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS NCT07108166 | Philip Morris Products S.A. | N/A |
| Recruiting | Reduce Tobacco Use in People Living With HIV in Switzerland NCT06789692 | University Hospital, Basel, Switzerland | N/A |
| Recruiting | Bayesian Neurobehavioral Phenotyping: From Mechanism Identification to Personalized Neuromodulation Treatments NCT06991062 | M.D. Anderson Cancer Center | N/A |
| Completed | Modern Nicotine Oral Product Abuse Liability NCT06777784 | RAI Services Company | N/A |
| Recruiting | A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home NCT06693700 | Memorial Sloan Kettering Cancer Center | N/A |
| Enrolling By Invitation | Salvation Army Tobacco Quit Line Referral Implementation Trial NCT06689774 | University of Wisconsin, Madison | N/A |
| Withdrawn | Young Adults and Low Nicotine Cigarettes NCT03699865 | Abramson Cancer Center at Penn Medicine | N/A |
| Recruiting | Refer2Quit: Evaluating a Proactive, Tailored, Population Health Approach for Tobacco Treatment for Household S NCT06582693 | Children's Hospital of Philadelphia | N/A |
| Recruiting | An Internet-based Dialectical Behaviour Therapy-informed Skills Training for Promoting Smoking Cessation and I NCT06575673 | Chinese University of Hong Kong | N/A |
| Not Yet Recruiting | The Effect of an Anti-Smoking Mobile Application on Self-Efficacy, Decision Making and Breath Carbon Monoxide NCT06492772 | Ege University | N/A |
| Recruiting | Enhancing Motivation to Quit Smoking Via Self-Help Intervention Targeted to Cancer Type NCT06484179 | University of Utah | N/A |
| Recruiting | The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers NCT06264154 | Abramson Cancer Center at Penn Medicine | N/A |
| Completed | CSD231005 Nicotine Pouch Biomarkers of Exposure NCT06303115 | RAI Services Company | N/A |
| Recruiting | Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction NCT06077240 | Yale University | N/A |
| Recruiting | "Effects of Balloon-blowing Exercises With Abdominal & Lumbar Core Muscle Activation Position Among Smokers" NCT06671288 | Foundation University Islamabad | N/A |
| Not Yet Recruiting | Impact of Smoking on Salivary Interleukin (IL)-39, IL-41, IL-1β, TNF-α Levels in Periodontal Disease NCT06528522 | Necmettin Erbakan University | — |
| Not Yet Recruiting | Relationships Between Tenascin C, Smoking and Periodontal Status NCT06523205 | Necmettin Erbakan University | — |
| Recruiting | The Efficacy of Conventional Screening Versus mHealth Screening in Early Detection of Oral Potentially Maligna NCT06535867 | Memorial Sloan Kettering Cancer Center | — |
| Recruiting | App for Reducing Cravings to Smoke NCT06088498 | H. Lee Moffitt Cancer Center and Research Institute | Phase 2 |
| Recruiting | The Potential of Kava in Enabling Tobacco Cessation - Its Holistic Effects in Managing Stress and Insomnia Ass NCT05814055 | University of Florida | Phase 2 |
| Recruiting | Effect of Different Centrifuge Values on Saliva High Sensitive C-Reactive Protein (Hs-CRP) Levels in Individua NCT06561971 | Izmir Katip Celebi University | N/A |
| Enrolling By Invitation | ADHAirE : a Randomized Controlled Trial to Improve the Implementation of Tobacco-free School Policies NCT06655038 | Université Catholique de Louvain | N/A |
| Recruiting | Implementation of Transcranial Magnetic Stimulation for Smoking Cessation NCT06346028 | Centre for Addiction and Mental Health | Phase 4 |
| Recruiting | Clinical Association Between Obstructive Sleep Apnea, Facial Pigmentation, and Vasovagal Symptoms. NCT06331819 | Jordan Collaborating Cardiology Group | — |
| Recruiting | Leveraging Community Pharmacists to Optimize Smoking Cessation Services for Rural Smokers in Appalachia NCT05660525 | University of Virginia | N/A |
| Completed | Treating Caregivers Who Smoke at AFCH NCT06051474 | University of Wisconsin, Madison | Phase 4 |
| Active Not Recruiting | Smartphone-delivered Scheduled Smoking With Compliance Facilitation as an Adjunct Cessation Therapy: a Feasibi NCT05763771 | M.D. Anderson Cancer Center | N/A |
| Completed | Implementation Science to Reduce the Disparity in Tobacco Treatment Among Individuals With Serious Mental Illn NCT05952401 | Washington University School of Medicine | N/A |
| Completed | Translational Research Center in Lung Cancer Disparities (TRACER) Project 2 NCT05490251 | Virginia Commonwealth University | — |
| Completed | Project WHADE: A Partner-Based Physical Activity Program for Women NCT06350604 | Rowan University | N/A |
| Completed | Trimethylamine N-oxide (TMAO) Levels in Periodontal Disease NCT06580431 | Istanbul Medipol University Hospital | N/A |
| Active Not Recruiting | Impact of Patient-Centered Approach for Communicating Coronary Calcium on Cardiovascular Health NCT06055972 | American College of Radiology | N/A |
| Completed | Diode Laser-Assisted Periodontal Therapy Enhances Clinical Outcomes for Deep Periodontal Pockets in Smokers NCT07213752 | Selcuk University | N/A |
| Unknown | The Effect of Education Based on Health Belief Model on Smoking Behaviors of Visually Impaired Individuals NCT05910203 | Cumhuriyet University | N/A |
| Enrolling By Invitation | A Patient-Oriented Research Mentoring Program in Tobacco Dependence and Implementation Science Research NCT05852860 | Abramson Cancer Center at Penn Medicine | N/A |
| Unknown | LDCT Chest In Assessment Of Apparently Healthy Smokers NCT06070922 | Assiut University | — |
| Completed | Aim 1: App for Reducing Cravings to Smoke NCT06923033 | H. Lee Moffitt Cancer Center and Research Institute | N/A |
| Active Not Recruiting | Process and Effect Evaluation of the KickAsh! Intervention NCT05920772 | University Ghent | N/A |
| Unknown | Exercise Training for Smoking Students NCT06291558 | Kırklareli University | N/A |
| Recruiting | Personalized Tobacco Treatment in Primary Care (MOTIVATE) NCT05846841 | Washington University School of Medicine | N/A |
| Completed | Perfect Fit: Evaluation of a Virtual Coach for Smoking Cessation and Physical Activity NCT06095999 | Leiden University Medical Center | N/A |
| Unknown | Mindfulness-based, Mobile Health (mHealth) Smoking Cessation Intervention in Vietnam NCT06228976 | Hanoi University of Public Health | N/A |
| Recruiting | Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention NCT06055036 | Ohio State University | N/A |
| Completed | Adolescent Inpatient Tobacco and ENDS Intervention NCT05936099 | Children's Mercy Hospital Kansas City | N/A |
| Recruiting | Take A Break - Rural NCT05790486 | Wake Forest University Health Sciences | N/A |
| Recruiting | Self-determination Plus Instant Messaging for Smokers With Cancer NCT05643469 | Chinese University of Hong Kong | N/A |
| Completed | Effect of Lower Limb Resistance Versus Endurance Training in Smokers NCT06674174 | Riphah International University | N/A |
| Completed | E-cigarettes as a Harm Reduction Strategy NCT06277271 | Prisma Health-Upstate | N/A |
| Recruiting | Effect of Tobacco Heating System (THS) on Closed Lower Limb Fracture Healing NCT05859451 | University Hospital Tuebingen | N/A |
| Unknown | Intervention for Smoking Cessation in Pre-Surgical Patients. NCT05961813 | Hospital Universitari Vall d'Hebron Research Institute | N/A |
| Unknown | Observe the Effect of Wheatgrass and Tulsi Formulation or Individuals Taken With Other Allopathic Drugs NCT05851040 | Swalife Biotech | — |
| Active Not Recruiting | A Pragmatic Trial of Chronic Disease Approaches to Ameliorate Tobacco Related Cardiovascular Disease Health Di NCT05671380 | University of Minnesota | N/A |
| Unknown | Effect of Passive Smoking on Orofacial Dysfunction Among a Group of Egyptian Children: A Cohort Study NCT05678153 | Ahram Canadian University | — |
| Recruiting | Linking Brain Network Dynamics to Imminent Smoking Lapse Risk and Behavior NCT05572671 | Penn State University | N/A |
| Withdrawn | Effect of Switching From Cigarette Smoking to THS on Systemic Endothelial Function in Subjects With Establishe NCT05566678 | Philip Morris Products S.A. | N/A |
| Completed | Message Testing in Aging African American Smokers NCT05819086 | University of Wisconsin, Madison | N/A |
| Completed | Ginglival Health Among Smokers Visiting Dental Hospital NCT06424600 | Pakistan Institute of Medical Sciences | — |
| Enrolling By Invitation | Precision Prevention Strategy to Increase Uptake and Engagement in Lung Cancer Screening and Smoking Cessation NCT05627674 | Washington University School of Medicine | N/A |
| Completed | Effects of Yoga on Pulmonary Parameters, Posture, Body Awareness and Quality of Life Among Chronic Smokers NCT05810298 | Yeditepe University | N/A |
| Terminated | Effect of Switching From Cigarette Smoking to THS on Disease Progression in Mild to Moderate COPD Subjects Wit NCT05569005 | Philip Morris Products S.A. | N/A |
| Recruiting | Taiwan Real-world LDCT Screening Behavior and Outcome Research for High Risk Subjects Based on Health Promotio NCT05557487 | Gee-Chen Chang | — |
| Active Not Recruiting | Effect of Helpers Program On-line Training on Smoking Relapse and Social Networks NCT05641974 | University of Colorado, Denver | N/A |
| Recruiting | Integrating Financial Coaching and Smoking Cessation Coaching NCT05154669 | NYU Langone Health | Phase 3 |
| Completed | Feasibility of a Virtual Smoking Cessation Program NCT05594199 | University Health Network, Toronto | N/A |
| Completed | Transcranial Magnetic Stimulation in Smokers: an Examination of Mediating Neural Pathways. NCT05651334 | Kent State University | Phase 2 |
| Recruiting | Evaluation of Lung Cancer CT Screening Performance Among Former and Current Smokers NCT05486455 | Hospital St. Joseph, Marseille, France | N/A |
| Completed | Reduced Exposure to HPHC in Smokers Switching From Cigarettes to Different Versions of THS NCT05599451 | Philip Morris Products S.A. | N/A |
| Recruiting | Ethnic Microaggressions and Smoking Behaviors Among Latinx Adults NCT05490927 | University of Houston | N/A |
| Completed | Messages About Reduced Nicotine in Combusted Tobacco Products NCT05506046 | Georgia State University | N/A |
| Completed | Impact of New Standards for Tobacco Products Among Dual E-Cigarette/Combusted Cigarette Users - Project 2 NCT05473585 | Duke University | N/A |
| Terminated | Preoperative Smoking Cessation in Patients Undergoing Surgery NCT05192837 | Luzerner Kantonsspital | N/A |
| Completed | Testing the Efficacy of A Scalable, Telephone-Delivered, Guided Imagery Tobacco Cessation Intervention NCT05277831 | University of Arizona | N/A |
| Completed | Message Testing in Older Adult Smokers NCT05471349 | University of Wisconsin, Madison | N/A |
| Unknown | Health Behaviour Change in Brazilians NCT05460897 | University of British Columbia | N/A |
| Completed | Improving Tobacco Treatment Rates for Cancer Patients Who Smoke NCT04738643 | Abramson Cancer Center at Penn Medicine | N/A |
| Completed | Reduction of Exposure, Inflammation, and Oxidative Stress Following At Least 2 Years of Switching to THS Use C NCT05385055 | Philip Morris Products S.A. | — |
| Active Not Recruiting | Reducing Tobacco-associated Lung Cancer Risk: A Randomized Clinical Trial of AB-free Kava NCT05081882 | University of Florida | Phase 2 |
| Completed | Randomized Pilot Study of a mHealth App for Ambivalent Smokers Living With HIV NCT05339659 | Kaiser Permanente | N/A |
| Completed | CSD200902: Assessment of Indoor Air Quality for a Heated Tobacco Product With Four Non-Combusted Cigarette Var NCT05363254 | RAI Services Company | N/A |
| Completed | CSD201301: Study to Assess Elements of Abuse Liability for Four P13 Nicotine Pouches NCT05294497 | RAI Services Company | N/A |
| Unknown | Effect of Periodontal Maintenance Therapy on Tooth Loss in Regular and Irregular Compliant Smokers and Non-Smo NCT04938089 | Saint-Joseph University | — |
| Completed | E-cigarettes for Harm Reduction in Adults With Asthma NCT05278065 | Brown University | N/A |
| Unknown | Coagulation Profile in Patients Undergoing Coronary Angiography and Percutaneous Coronary Intervention NCT05336669 | Centre of Postgraduate Medical Education | — |
| Completed | CSD210903: A Study to Determine Subject Puffing Patterns of a Heated Tobacco Product With Four Non-Combusted C NCT05307822 | RAI Services Company | N/A |
| Recruiting | Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondh NCT04783857 | University of Minnesota | Phase 4 |
| Recruiting | The Man Van Project NCT06357416 | Royal Marsden NHS Foundation Trust | N/A |
| Active Not Recruiting | Factors Sustaining Tobacco Abstinence in Cancer Patients Treated With Radio-chemotherapy or Radiotherapy NCT06910566 | Centre Oscar Lambret | — |
| Completed | CSD201201: Study to Assess Elements of Abuse Liability for Electronic Nicotine Delivery System P12 NCT05210699 | RAI Services Company | N/A |
| Unknown | Smoking Prevention Program in Poland NCT05488743 | Wroclaw Medical University | — |
| Completed | Nicotine Pharmacokinetics and Subjective Effects of Nicotine Pouch 1.0 Compared to Velo® Ice Cool and Zyn® Coo NCT05317195 | Philip Morris Products S.A. | N/A |
| Completed | CSD201202: A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery System P12 NCT05239884 | RAI Services Company | N/A |
| Unknown | The Effect of Smoking and Chlorhexidine on Periodontal Tissues After Non- Surgical Periodontal Therapy in Pati NCT06191497 | University of Rijeka | N/A |
| Completed | Evaluation of Immunological, Microbiological and Metabolomic Profiles in COPD NCT06826560 | Medical University of Warsaw | — |
| Unknown | Peri-implant Marginal Bone Loss and Implant Failure in Patients With Smoking Habit NCT05390242 | University of Barcelona | — |
| Completed | CSD201203: A Study to Determine Subject Puffing Patterns of a Non-cylindrical, Closed, Electronic Nicotine Del NCT05118139 | RAI Services Company | N/A |
| Recruiting | Atorvastatin Effect on Reduction of COPD Exacerbations NCT04789057 | Medical University of Bialystok | Phase 4 |
| Completed | Supporting Smoke-Free Policy Compliance in Public Housing NCT05016505 | Columbia University | N/A |
| Completed | Promoting Early Adolescent Non-smoking With a Game Intervention Supporting Self-efficacy NCT05290103 | University of Turku | N/A |
| Completed | CSD201004: An Actual Use Study of P10 and P13 Nicotine Pouches Among U.S. Adult Smokers NCT05184920 | RAI Services Company | — |
| Unknown | Population Pharmacokinetic - Pharmacodynamic Models of Chronic Disease Therapeutics for Smokers NCT05126381 | The Second Affiliated Hospital of Chongqing Medical University | — |
| Completed | BAT3221032: A Study to Evaluate the Effects of Switching From Cigarette Smoking to Using One of Five Variants NCT05142436 | British American Tobacco (Investments) Limited | N/A |
| Completed | Testing Integrative Smoking Cessation for HIV Patients NCT05030766 | University of Miami | Phase 4 |
| Recruiting | Biopsychosocial Predictors of Nicotine Relapse NCT06470321 | University of Cyprus | N/A |
| Terminated | Remote Incentives for Smoking Cessation Among AN Pregnant Women NCT05019170 | University of Vermont | N/A |
| Completed | Evaluation of SOST, TWEAK, RANKL, OPG Levels in Smokers and Non-Smokers With Periodontitis NCT06103578 | Gazi University | — |
| Completed | CSD200907: A Study to Assess Elements of Abuse Liability for a Heated Tobacco Product With Four Non-Combusted NCT05114863 | RAI Services Company | N/A |
| Completed | CSD201001: Study to Assess Elements of Abuse Liability for Three Nicotine Pouches NCT05129657 | RAI Services Company | N/A |
| Withdrawn | Mobile Health Interventions for Medication Adherence Among PLWH NCT04191278 | Duke University | Phase 4 |
| Recruiting | Cigarette Consumption After switchinG to High or Low Nicotine strENght E-cigaretteS In Smokers With Schizophre NCT04452175 | University of Catania | N/A |
| Completed | CSD210904: Study to Assess Actual Use of a Heated Tobacco Product With Four Non-Combusted Cigarette Variants i NCT05102786 | RAI Services Company | — |
| Active Not Recruiting | Enhancing Mental and Physical Health of Women Veterans NCT05050266 | VA Office of Research and Development | N/A |
| Completed | CSD201002: Study to Assess Nicotine Uptake From P10 Nicotine Pouches NCT05081154 | RAI Services Company | N/A |
| Completed | Prevention of Oral DNA Damage by Black Raspberries NCT04372914 | Milton S. Hershey Medical Center | N/A |
| Completed | Smoking Increases the Risk of Postoperative Wound Complications: a Propensity Score-matched Cohort Study NCT05142956 | Taipei Medical University Hospital | — |
| Withdrawn | Impact of New Product Standards for JUUL Among Dual JUUL/Combusted Cigarette Users NCT04179617 | Duke University | N/A |
| Completed | Use of a Smartphone Application (App) to Assist a Cognitive-Behavioral Smoking Cessation Treatment NCT04765813 | University of Santiago de Compostela | N/A |
| Completed | The Effects of IQOS Use on Cigarette Smoking Behaviors NCT05076708 | University of Pennsylvania | EARLY_Phase 1 |
| Unknown | Perceptions and Barriers About Cessation of Smoking Among IBD Patients NCT05182996 | Keimyung University Dongsan Medical Center | N/A |
| Completed | Potential Effect for the Smoking on Periodontitis From the Perspective of Arginine Metabolites NCT05448976 | Istanbul Medipol University Hospital | N/A |
| Completed | Motivating a Spectrum of Cancer Patients to Quit Smoking NCT04914000 | H. Lee Moffitt Cancer Center and Research Institute | N/A |
| Completed | Project HEALS (Helping and Empowering pAtients for Living a Life Smoke-free NCT05362318 | H. Lee Moffitt Cancer Center and Research Institute | N/A |
| Active Not Recruiting | Improving the Reach & Effectiveness of Smoking Cessation Services Targeted to Veterans Living With HIV NCT04505371 | Seattle Institute for Biomedical and Clinical Research | N/A |
| Completed | The Effect of Scaling and Root Planing on Oral Inflammatory Biomarkers Among E-cig Users and Non-smokers NCT05745324 | Kuwait University | N/A |
| Unknown | Effectiveness of Negotiating Self-determination to Reduce Cigarette Consumption NCT02763527 | The University of Hong Kong | N/A |
| Completed | Young Adults' Reactions to Low Nicotine Cigarette Advertising NCT04906148 | Abramson Cancer Center at Penn Medicine | N/A |
| Active Not Recruiting | The Effect of Tobacco Products on Wound Healing NCT04870970 | University of Minnesota | — |
| Completed | Improving Tobacco Treatment Rates for Outpatient Cancer Patients Who Smoke NCT04737031 | Abramson Cancer Center at Penn Medicine | N/A |
| Completed | BAPS in Botswana: The Thotloetso Trial NCT04532970 | Abramson Cancer Center at Penn Medicine | N/A |
| Completed | Impact of Low Nicotine Cigarette Messaging on Perceptions and Cigarette Choices NCT04740008 | Masonic Cancer Center, University of Minnesota | EARLY_Phase 1 |
| Completed | The Effect of Motivational Interviewing Technique on Smoking Urge and Smoking Cessation Success in Teachers NCT05374707 | Celal Bayar University | N/A |
| Active Not Recruiting | A Study to Develop a Strategy to Increase Lung Cancer Screening in Women Who May Be at Risk for Lung Cancer NCT04848961 | Memorial Sloan Kettering Cancer Center | EARLY_Phase 1 |
| Completed | Clinical Learning Study for a Mobile Smoking Cessation Program NCT04857515 | Click Therapeutics, Inc. | — |
| Unknown | Lung Macrophage Populations and Functions in Chronic Obstructive Pulmonary Disease (COPD)-Susceptible Smokers NCT04722835 | University of California, San Francisco | — |
| Completed | Preference-based Tools for Smoking Cessation Among Disadvantaged Smokers, a Pragmatic Randomised Controlled Tr NCT04654585 | Société de Formation Thérapeutique du Généraliste - Recherche | N/A |
| Completed | CSD210202: A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery Systems NCT04751461 | RAI Services Company | N/A |
| Completed | STARS (Smoking Treatment And Remote Sampling) Study NCT04525755 | Medical University of South Carolina | Phase 1 / Phase 2 |
| Completed | Peer-delivered and Technology-Assisted Integrated Illness Management and Recovery NCT04481737 | Dartmouth-Hitchcock Medical Center | N/A |
| Active Not Recruiting | Digitally Enhanced Smoking Cessation for High Risk Smokers NCT04691297 | Dana-Farber Cancer Institute | N/A |
| Unknown | Clinical Features of Smoker Patients With Chronic Obstructive Pulmonary Disease NCT04711629 | Izmir Katip Celebi University | N/A |
| Active Not Recruiting | Racial Differences in Circadian and Sleep Mechanisms for Nicotine Dependence, Craving, and Withdrawal NCT03968900 | University of Alabama at Birmingham | N/A |
| Withdrawn | Opioids and Smoking Cessation NCT03857139 | University of Houston | Phase 4 |
| Completed | Metabolism Informed Smoking Treatment: The MIST RCT NCT04590404 | Vanderbilt-Ingram Cancer Center | Phase 3 |
| Completed | Alcohol and Cigarette Craving During Oxytocin Treatment NCT04071119 | Brown University | Phase 1 |
| Completed | Evaluation of the 1999 and 2018 Periodontal Disease Classifications: a Retrospective Study NCT04815772 | Okan University | — |
| Completed | Smoking Cessation Pilot for People Living With HIV (PLWH) NCT04808609 | Columbia University | N/A |
| Completed | Acute Effects of TCIG vs ECIG in PLWH NCT04568395 | University of California, Los Angeles | N/A |
| Completed | Metabolism of NNK in Japanese Americans NCT04228952 | Masonic Cancer Center, University of Minnesota | — |
| Completed | Electronic Proactive Outreach for Smokers With COPD NCT04462289 | VA Office of Research and Development | N/A |
| Completed | QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit A NCT04159571 | Wake Forest University Health Sciences | N/A |
| Active Not Recruiting | Centralized Lung Cancer EARly Detection Among Smokers (CLEAR Study) NCT04200534 | M.D. Anderson Cancer Center | EARLY_Phase 1 |
| Completed | IQOS (Non-Cigarette Tobacco Product) Pilot Study NCT04357379 | Medical University of South Carolina | N/A |
| Unknown | Influence of the Consumption of Conventional and Electric Cigarettes on Skin Circulation NCT04645914 | University Hospital Muenster | N/A |
| Completed | Salt-Based E-cigarette NCT04238832 | Medical University of South Carolina | N/A |
| Completed | CSD190601: A Study to Determine Subject Puffing Patterns of Electronic Nicotine Delivery Systems in an Ambulat NCT04308434 | RAI Services Company | N/A |
| Completed | CSD190401: A Study to Assess Elements of Abuse Liability for Nicotine-containing Pouch Tobacco Products NCT04372290 | RAI Services Company | N/A |
| Unknown | Effectiveness of Tobacco Cessation Interventions in Sweden NCT04819152 | Lund University | — |
| Completed | DELPHI in Subjects at Risk for Stroke and Dementia NCT03884647 | QuantalX Neuroscience | — |
| Completed | Three Dosing Regimens of Dextromethorphan (DXM) Reportedly Used in Major Depressive Disorder NCT04226352 | Johns Hopkins University | Phase 1 |
| Completed | The Effects of Smoking on Mortality in Patients With Acute Respiratory Syndrome Coronavirus 2 Infection NCT04874363 | Sisli Hamidiye Etfal Training and Research Hospital | — |
| Completed | Cigar Packaging Study NCT04605874 | Abramson Cancer Center at Penn Medicine | N/A |
| Recruiting | Effects of a Specific Substance in Smokers NCT04281979 | Oregon Health and Science University | N/A |
| Terminated | Peri-procedural Smoking Cessation Program in Patients With Chronic Pain NCT04605744 | The Cooper Health System | N/A |
| Terminated | PRogetto Salute Parma NCT04282694 | University of Parma | — |
| Completed | A Focus Group Study to Explore Smoking Triggers and Acceptability of Just-in-time Adaptive Intervent NCT05231421 | University of Colorado, Denver | — |
| Completed | Electronic Hookah and Endothelial Cell Function NCT04133376 | University of California, Los Angeles | N/A |
| Completed | CSD190501: A Study to Determine Subject Puffing Patterns of an Electronic Nicotine Delivery System in an Ambul NCT04226404 | RAI Services Company | N/A |
| Completed | Effectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/ Depression in People Living NCT03904186 | Massachusetts General Hospital | N/A |
| Completed | GeoScan and Remote Geo Smoking Study: Neural and Behavioral Correlates of Smokers' Exposure to Retail Environm NCT04279483 | Abramson Cancer Center at Penn Medicine | N/A |
| Completed | Connecting Alaska Native People to Quit Smoking NCT03645941 | Mayo Clinic | N/A |
| Suspended | The SmokeFree App Smoking Cessation Study NCT05094583 | Chelsea and Westminster NHS Foundation Trust | — |
| Completed | CSD190301: A Study to Assess Elements of Abuse Liability for Two Dissolvable Nicotine Lozenge Tobacco Products NCT04167384 | RAI Services Company | N/A |
| Unknown | Short Term Effect of Interscapular Cupping on Chest Expansion in Sedentary Male Smokers NCT04238182 | Cairo University | N/A |
| Withdrawn | HIV-1 and Brain Interaction on Smoking Comorbidity NCT03308331 | University of Maryland, Baltimore | N/A |
| Completed | Mobile Evidence-Based Smoking Cessation for Veterans Living With HIV (MESH) NCT04135937 | VA Office of Research and Development | Phase 4 |
| Completed | JUUL vs. Mod E-cigarette Study NCT04237272 | Medical University of South Carolina | N/A |
| Completed | CPT-SMART for Treatment of PTSD and Cigarette Smoking NCT03978442 | VA Office of Research and Development | Phase 4 |
| Completed | Varenicline Light Smoking Pilot NCT04089982 | Duke University | Phase 4 |
| Completed | CSD190203: A Study to Determine Subject Puffing Patterns of an Electronic Nicotine Delivery System in an Ambul NCT04104152 | RAI Services Company | N/A |
| Completed | Utilizing Augmented Reality as an Adjunct for Smoking Cessation NCT04101422 | H. Lee Moffitt Cancer Center and Research Institute | N/A |
| Completed | CSD190202: Study to Assess Elements of Abuse Liability for Two Electronic Nicotine Delivery Systems NCT04094363 | RAI Services Company | N/A |
| Completed | Applying Novel Technologies and Methods to Self-Regulation: Behavior Change Tools for Smoking and Binge Eating NCT03687658 | Stanford University | N/A |
| Completed | Smartphone Intervention for Smoking Cessation and Improving Adherence to Treatment Among HIV Patients NCT03999411 | University of Miami | Phase 4 |
| Completed | Deliver an Evidence-based Smoking Cessation Intervention for Smokers Attending A&E Departments in Hong Kong NCT03818360 | The University of Hong Kong | N/A |
| Completed | Preventing Relapse to Smoking Among Prisoners After Release NCT04271371 | University of Nottingham | — |
| Completed | Interaction Between Smoking, GCF Periostin, IL17A, IL17E and Non-surgical Periodontal Therapy NCT06326073 | Ondokuz Mayıs University | N/A |
| Terminated | Ciliation and Mucus Rheology Parameters Determined Via Air-liquid-interface Cell Cultures in Non-smoking, Smok NCT03187860 | University Hospital, Montpellier | N/A |
| Completed | A Pilot Study of the Learn, Connect, and Quit Mobile Application NCT03978455 | University of Wisconsin, Madison | — |
| Completed | A Comparative Pharmacokinetic and Pharmacodynamic Study of Sildenafil in Adult Smokers and Non Smokers NCT04100759 | Ain Shams University | Phase 1 / Phase 2 |
| Completed | BRP1802 Smoking Abstinence Study NCT04979013 | RAI Services Company | N/A |
| Completed | Smoking Cessation E-Visit NCT04316260 | Medical University of South Carolina | N/A |
| Completed | Impact of E-cigarette Characteristics on Reinforcement and Tobacco Use Patterns NCT03844672 | Medical University of South Carolina | N/A |
| Completed | Engaging Patients in Tobacco Cessation Resources in Dental Settings NCT03656874 | HealthPartners Institute | N/A |
| Completed | DECIDE: Developing Tools for Lung Cancer Screening Discussion Improvement NCT03891602 | Hackensack Meridian Health | — |
| Active Not Recruiting | A Longitudinal Cohort Study to Evaluate Cardiovascular Risk Factors and Disease in Haiti NCT03892265 | Weill Medical College of Cornell University | — |
| Completed | Using Mobile Technology to Improve Self-Regulation NCT03774433 | Dartmouth-Hitchcock Medical Center | N/A |
| Completed | Implementation and Dissemination of an Evidence-Based Tobacco Product Use Prevention Videogame Intervention Wi NCT03815591 | Yale University | N/A |
| Completed | Effect of Switching From Cigarette Smoking to IQOS on Exercise Capacity NCT03887117 | Philip Morris Products S.A. | N/A |
| Completed | Effect of Smoking on Periodontal Therapy in Periodontitis NCT05262153 | Marmara University | N/A |
| Completed | Preventing Smoking Relapse After Total Joint Replacement Surgery NCT03673228 | NYU Langone Health | N/A |
| Completed | Evaluation of a School-based Smoking Prevention and Cessation Programme in Negeri Sembilan NCT04378725 | University of Malaya | N/A |
| Completed | Hollings Cancer Center Varenicline Sampling Study NCT03742154 | Medical University of South Carolina | EARLY_Phase 1 |
| Completed | Trial of Indole-3-Carbinol and Silibinin NCT03687073 | Masonic Cancer Center, University of Minnesota | Phase 1 |
| Terminated | Impact of Twice-daily Measurement of Expired CO During Hospitalization on Smoking NCT03729063 | University Hospital, Montpellier | N/A |
| Completed | Effects of Smoking on Oral Tissue Samples NCT05484765 | Istanbul Medipol University Hospital | — |
| Completed | An Extended Facebook Intervention for Young Sexual and Gender Minority Smokers NCT03553992 | University of California, San Francisco | N/A |
| Terminated | In-vivo Effects of E-cigarette Aerosol on Innate Lung Host Defense NCT03700892 | University of North Carolina, Chapel Hill | N/A |
| Completed | COMET2 Project 1 Filter Ventilation Study NCT03637972 | Masonic Cancer Center, University of Minnesota | Phase 3 |
| Terminated | Mindfulness Training Plus Oxytocin Effects on Smoking Behavior NCT03819231 | University of Southern California | Phase 2 / Phase 3 |
| Completed | Comparison of Abdominal Aortic Aneurysm Growth in Adult Smoking Patients Who Either Switch to IQOS, Continue S NCT03837704 | Philip Morris Products S.A. | N/A |
| Completed | Smoke-free Air Coalitions in Georgia and Armenia NCT03447912 | Emory University | N/A |
| Completed | A Cluster-RCT of SHS Among Primary School Students NCT03380234 | The University of Hong Kong | N/A |
| Completed | Helping Ethnic Minority in Hong Kong to Quit Smoking by Understanding Their Knowledge, Attitude and Behavior R NCT04025333 | The University of Hong Kong | — |
| Completed | Addictive Potential of LCCs in Dual Users NCT03496077 | UConn Health | N/A |
| Completed | Couples Dynamics and Smoking Cessation NCT03885336 | University of Southern California | — |
| Completed | Project 2 Cigarette and E-cigarette Nicotine Content and E-liquid Flavors NCT03185546 | Wake Forest University Health Sciences | N/A |
| Withdrawn | Usability and Pilot Testing - Intervention for Smoking Cessation NCT02955095 | NYU Langone Health | N/A |
| Completed | Clinical Evaluation of Smoker Periodontal Subjects After Lactobacillus-reuteri Probiotics and Antibiotics Ther NCT04209777 | Dow University of Health Sciences | Phase 3 |
| Unknown | Predicting Sleep, Smoking, and Lung Health Disparities in African American Adults NCT03534076 | Temple University | — |
| Withdrawn | Korean Youth Smoking Cessation Study NCT02021175 | University of California, Los Angeles | N/A |
| Completed | Clinical Outcomes of a Nationwide, Naturalistic E-Cig Trial (CONNECT) NCT03453385 | Medical University of South Carolina | N/A |
| Completed | Nicotine TMS EFT Smoking Pilot Study NCT03579953 | Medical University of South Carolina | EARLY_Phase 1 |
| Completed | A Facebook Intervention for Young Sexual and Gender Minority Smokers NCT03259360 | University of California, San Francisco | N/A |
| Completed | Impact of Exclusive Use of Low Nicotine Cigarettes on Compensatory Smoking NCT03311646 | Medical University of South Carolina | N/A |
| Completed | Smoking Cessation Smartphone App for Cancer Patients (Quit2Heal Study) NCT03600038 | Fred Hutchinson Cancer Center | N/A |
| Completed | Feasibility and Acceptability of a Text Messaging Intervention to Increase Smoking Cessation in Vietnam NCT03219541 | NYU Langone Health | N/A |
| Unknown | Smokerface Mirroring in Brazil RCT NCT03178227 | University of Giessen | N/A |
| Terminated | Electroretinogram: a New Human Biomarker for Smoking Cessation Treatment NCT03213418 | New York State Psychiatric Institute | N/A |
| Completed | Sensory Perception of Sweet Flavors in E-Cigarette NCT03332953 | Oregon State University | N/A |
| Unknown | Testing a Self-affirmation Intervention for Use in a Mobile Application NCT03405220 | Kent State University | N/A |
| Completed | Using Mobile Technology to Better Understand and Measure Self-Regulation NCT03352713 | Dartmouth-Hitchcock Medical Center | N/A |
| Unknown | Grip&Health: Behavioural Intervention to Reduce Smoking, Stress and Improve Financial Health in Low-SES in Rot NCT03553979 | Erasmus Medical Center | N/A |
| Completed | Effect of Smoking and Periodontal Therapy on Salivary and Gingival Crevicular IL-17 and IL-35 NCT05281848 | Gazi University | N/A |
| Completed | Pain and Smoking Study NCT02971137 | VA Office of Research and Development | N/A |
| Completed | Smoking Tobacco and Drinking Study NCT03163303 | University of California, San Francisco | Phase 4 |
| Completed | Imaging the Neurochemistry of Drug Addiction With PET NCT02817698 | Yale University | EARLY_Phase 1 |
| Completed | Development of a Videogame Prototype Targeting Cigarette and Marijuana Smoking, and Tobacco Product Prevention NCT03722888 | Yale University | N/A |
| Completed | The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients NCT03938584 | Hennepin Healthcare Research Institute | N/A |
| Unknown | Tobacco Use and Uptake of COVID-19 Vaccinations NCT05479383 | Finnish Institute for Health and Welfare | — |
| Completed | Chicago Community Health Study NCT04460417 | University of Chicago | N/A |
| Completed | Implementing and Testing a Cardiovascular Assessment Screening Program (CASP) NCT03170752 | Memorial University of Newfoundland | N/A |
| Completed | Pulmonary Nodule Detection: Comparison of an Ultra Low Dose vs Standard Scan. NCT03305978 | University Hospital, Grenoble | N/A |
| Completed | CSD170304: Study to Assess Nicotine Uptake in Smokers From Electronic and Combustible Cigarettes NCT03294356 | RAI Services Company | N/A |
| Completed | A Nicotine Pharmacokinetics and Smoking Behaviour Study Examining Cigarette Ingredients NCT03272295 | British American Tobacco (Investments) Limited | N/A |
| Terminated | Comprehensive Care Program SBRT NCT03267368 | Corewell Health East | N/A |
| Completed | Online Automated Self-Hypnosis Program NCT03931772 | Stanford University | N/A |
| Terminated | Hookah Smoking, Carbon Monoxide, and Coronary Endothelial Function NCT03166787 | Cedars-Sinai Medical Center | Phase 1 |
| Terminated | Low Dose Computed Tomography for Lung Cancer Screening NCT03084835 | Mayo Clinic | N/A |
| Completed | Modeling Bronchial Epithelium Modifications Associated With COPD Using iPS NCT03181204 | University Hospital, Montpellier | — |
| Completed | Studying Partial-agonists for Ethanol and Tobacco Elimination in Russians With HIV (St PETER HIV) NCT02797587 | Boston Medical Center | Phase 2 / Phase 3 |
| Completed | CSD170302: Study to Assess Nicotine Uptake in Smokers From Electronic Cigarettes NCT03233997 | RAI Services Company | N/A |
| Completed | CSD170303: Study to Assess Nicotine Uptake in Smokers From Electronic Cigarettes NCT03234010 | RAI Services Company | N/A |
| Completed | Digital Ankle Brachial Index (ABI) as a Screening Tool in Detecting Peripheral Arterial Disease NCT03161327 | St. Louis University | N/A |
| Completed | e-Cigarette - DNA Adducts NCT03284632 | University of Minnesota | — |
| Completed | E-cigarette Nicotine Pharmacokinetic Study NCT03178981 | British American Tobacco (Investments) Limited | N/A |
| Completed | Impact of Smoking and Its Cessation on Systemic and Airway Immune Activation NCT02836067 | Boston Medical Center | N/A |
| Completed | Helping Poor Smokers Quit NCT03194958 | Washington University School of Medicine | N/A |
| Terminated | Smartphone App and CO Self-monitoring for Smoking Cessation NCT02840513 | Alain Nordmann | Phase 4 |
| Completed | Trial of An Innovative Smartphone Intervention for Smoking Cessation NCT02724462 | Fred Hutchinson Cancer Center | N/A |
| Completed | COach2Quit TRIAL: Assessing a Prototype Personal Carbon Monoxide Monitor for Smoking Cessation NCT03142932 | Johns Hopkins University | N/A |
| Completed | CSD170501: Study to Assess Biomarkers of Tobacco Exposure in Smokers During In-Clinic Confinement Switch to an NCT03170674 | RAI Services Company | N/A |
| Completed | The Effects of Inhaled Aclidinium Bromide/Formoterol Fumarate on Inspiratory Pleural Pressures in Smokers NCT03104634 | McGill University Health Centre/Research Institute of the McGill University Health Centre | Phase 3 |
| Completed | CSD170401: Study to Assess Elements of Abuse Liability for Three Electronic Tobacco Vapor Products During an 1 NCT03126357 | RAI Services Company | N/A |
| Completed | Web-Delivered Acceptance & Commitment Therapy for Smokers With Bipolar Disorder NCT02750904 | Fred Hutchinson Cancer Center | N/A |
| Completed | CSD170301: An Unblinded, Parallel, Randomized Study to Assess Nicotine Uptake in Smokers From Four Different E NCT03105804 | RAI Services Company | N/A |
| Completed | Feasibility and Smokers' Reactions to DNA Feedback NCT02922790 | Duke University | N/A |
| Completed | CSD1603: A Crossover Study to Evaluate the Exposure to "Tar" and Nicotine From 100s Menthol Cigarette Products NCT03063047 | RAI Services Company | N/A |
| Completed | CSD1602: A Crossover Study to Evaluate the Exposure to "Tar" and Nicotine From Two King Size Menthol Cigarette NCT03063034 | RAI Services Company | N/A |
| Completed | Neuroimaging Reward, Behavioral Treatment, and Smoking Cessation NCT02927847 | Maggie M Sweitzer, PhD | Phase 1 / Phase 2 |
| Completed | Apoptotic Changes in Gingiva Caused by Smoking NCT03631498 | Tokat Gaziosmanpasa University | — |
| Completed | Novel Approaches to Reducing Tobacco Related Harm NCT02600273 | Duke University | N/A |
| Completed | Combined Bio- and Neuro- Feedback vs. Varenicline Use for Smoking Cessation NCT02991781 | Aristotle University Of Thessaloniki | N/A |
| Completed | Smoking Treatment and Exercise Program for Underserved Populations (STEP UP) NCT02873754 | Duke University | N/A |
| Completed | Development of a Videogame Prototype Targeting Cigarette and Marijuana Smoking, and Tobacco Product Prevention NCT03107936 | Yale University | N/A |