NCT07412639

Tabata Exercise on Nitric Oxide Synthases and Maresin

Differential Effects of Tabata Exercise on Nitric Oxide Synthases and Maresin in Smokers and Non-Smokers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Ataturk University · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Smoking causes chronic inflammation and endothelial dysfunction through alterations in nitric oxide synthase (NOS) pathways. Maresin is an anti-inflammatory pro-resolving lipid mediator that plays important roles in the resolution of inflammatory processes. Tabata exercise is a short-duration, high-intensity exercise modality with beneficial effects on the cardiovascular system. The aim of this study was to comparatively evaluate the effects of tabata exercise on iNOS, eNOS, and Maresin levels, as well as the relationships among these biomarkers, in smokers and non-smokers.

Conditions

• Smoking
• Smoking, Cigarette

Interventions

Type	Name	Description
OTHER	Tabata Exercise Protocol	The Tabata protocol consisted of 20-second high-intensity intervals exceeding 70 % of VO₂max and approaching \~90 % of VO₂max, followed by 10 seconds of rest, repeated for 4 minutes per set. Exercises included high knees, froggers, speed skaters, jumping jacks, and mountain climbers. Following the original Tabata design \[29\], each work-rest cycle was repeated eight times. Each training session began with a 10-15 minute warm-up and concluded with a 10-15 minute cool-down. The total number of sets ranged from 1 to 4, and the number of exercises per session ranged from 4 to 8. Training intensity progressively increased from 30 % to 89 % of maximal effort according to the principle of progressive overload.

Timeline

• Start date: 2025-10-24
• Primary completion: 2026-01-16
• Completion: 2026-01-30
• First posted: 2026-02-17
• Last updated: 2026-02-17

Locations

1 site across 1 country: Turkey (Türkiye)