NCT03311646

Impact of Exclusive Use of Low Nicotine Cigarettes on Compensatory Smoking

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 31 (actual)
• Sponsor: Medical University of South Carolina · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Smoking is the leading cause of preventable death in the United States. An FDA-mandated reduction in the nicotine content of cigarettes might reduce the health burden of tobacco by reducing the prevalence of smoking. The proposed project will test the impact of nicotine reduction on smoking behavior and smoke exposure in a setting where participants are restricted from using their usual brand cigarettes.

Detailed description

Smoking is the leading cause of preventable death in the United States. An FDA-mandated reduction in the nicotine content of cigarettes might reduce the health burden of tobacco by reducing the prevalence of smoking. The proposed project will test the impact of nicotine reduction on smoking behavior and smoke exposure in a setting where participants are restricted from using their usual brand cigarettes.Smokers will be confined to a hotel for two hotel stays (five days/ four nights each) during which they will only have access to the investigational cigarettes provided to them. The nicotine content of the investigational cigarettes may differ between the two weeks. Participants will enter the hotel in groups of 10 and everyone in a given stay will receive the same investigational cigarette. The first aim will assess measures of smoke and nicotine exposure including urinary cotinine and expired carbon monoxide. The second aim will assess behavioral measures of smoking including cigarettes smoked per day and puff topography.

Conditions

• Smoking

Interventions

Type	Name	Description
OTHER	Normal nicotine content cigarettes (NNC, Baseline)	Participants will exclusively smoke research cigarettes that have a normal nicotine content for five days/four nights while staying in a hotel.
OTHER	Very low nicotine content (VLNC)	Participants will exclusively smoke research cigarettes that have a very low nicotine content for five days/four nights while staying in a hotel.

Timeline

• Start date: 2018-04-15
• Primary completion: 2018-11-15
• Completion: 2018-12-01
• First posted: 2017-10-17
• Last updated: 2020-01-28
• Results posted: 2020-01-18

Locations

1 site across 1 country: United States