NCT04870970

The Effect of Tobacco Products on Wound Healing

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: University of Minnesota · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to evaluate the effect of various tobacco products (including but not limited to combustible cigarettes, medicinal nicotine, electronic cigarettes, and smokeless tobacco) on cutaneous wound healing. There will also be a non- smoking control group. This study will be designed as a pilot study. The majority of individuals will be recruited from ongoing studies at the University of Minnesota - Tobacco Research Programs.

Detailed description

Participants will be recruited from ongoing studies will some recruitment of tobacco users and non-smoking controls outside of ongoing studies. In this prospective, cohort study of various tobacco users and non-smokers, a punch biopsy model of wound healing will be used to determine the effects of various tobacco products on inflammatory response and oxidative stress response to wounding: 1. Clinical wound inflammation as assessed by: 1. Thermography, 2. Clinical assessment, 3. Laser Doppler Technologies, 4. Transcutaneous oxygen assessment 2. Biological wound inflammation as assessed by: 1. Cytokine profiles, 2. Histology, 3. Genetic assessment, 4. Epigenetic evaluation 3. Systemic inflammation as assessed by: 1. Biomarkers, 2. Cell counts

Conditions

• Smoking
• Tobacco Use
• Tobacco Smoking

Timeline

• Start date: 2021-05-18
• Primary completion: 2027-02-01
• Completion: 2027-02-01
• First posted: 2021-05-04
• Last updated: 2026-02-18

Locations

1 site across 1 country: United States