| Not Yet Recruiting | Smoking Harm Reduction Using E-cigarettes and Cytisine NCT07274475 | Centre for Addiction and Mental Health | N/A |
| Not Yet Recruiting | A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery Systems NCT07323563 | RAI Services Company | N/A |
| Not Yet Recruiting | Efficacy of the Proactive Automatized Lifestyle Intervention NCT07441603 | University Medicine Greifswald | N/A |
| Recruiting | Using Novel Behavioral Economic Measures to Characterize Dual Marijuana and Tobacco Use in Young Adults NCT07398443 | Brown University | N/A |
| Not Yet Recruiting | Abuse Liability for Eight Electronic Nicotine Products NCT07323511 | RAI Services Company | N/A |
| Not Yet Recruiting | Abuse Liability for Four Heated Tobacco Product (HTP) Consumables and Two HTP Devices NCT07267195 | RAI Services Company | N/A |
| Recruiting | Abuse Liability for Five Modern Oral Nicotine Products NCT07132814 | RAI Services Company | N/A |
| Recruiting | Trauma-Informed Care for Smoking Cessation for Pregnancy NCT07129590 | University of California, San Francisco | N/A |
| Recruiting | Intervention to Increase Intention to Change Alcohol/Tobacco Use in Veterans With Chronic Disease NCT07039175 | VA Office of Research and Development | Phase 3 |
| Recruiting | Buteyko Breathing and Approach of Smoking Hygiene: Effects on Dysfucntion of Eustachian Tube and Lung Function NCT07236580 | Cairo University | N/A |
| Recruiting | Effects of Cannabidiol on Stress and Nicotine Withdrawal NCT07001930 | Johns Hopkins University | Phase 1 |
| Recruiting | CONNECT Cancer Survivors With Tobacco Treatment NCT07020273 | Washington University School of Medicine | N/A |
| Recruiting | Scaling Up Community-based Noncommunicable Disease Research Into Practice in Pokhara Metropolitan City of Nepa NCT06740708 | Johns Hopkins Bloomberg School of Public Health | N/A |
| Active Not Recruiting | E-cigarette Harm Reduction Among PLWHA in South Africa NCT06169813 | NYU Langone Health | Phase 1 |
| Recruiting | tDCS Plus Varenicline for Smoking Cessation NCT06798324 | Centre for Addiction and Mental Health | Phase 4 |
| Recruiting | Reach Through Equitable Implementation in Utah NCT06881069 | University of Utah | N/A |
| Recruiting | A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home NCT06693700 | Memorial Sloan Kettering Cancer Center | N/A |
| Recruiting | Cannabidiol for Reducing Cigarette Use NCT06218056 | University of California, Los Angeles | Phase 2 |
| Recruiting | The Efficacy of Conventional Screening Versus mHealth Screening in Early Detection of Oral Potentially Maligna NCT06535867 | Memorial Sloan Kettering Cancer Center | — |
| Recruiting | Smoke-free Home Study in Subsidized Housing NCT06170437 | University of California, San Francisco | N/A |
| Active Not Recruiting | Vaping Cessation Using the Ottawa Model for Smoking Cessation Among E-Cigarette Users NCT06164678 | Ottawa Heart Institute Research Corporation | N/A |
| Recruiting | Brief Behavioural Economic Intervention for Smoking Cessation NCT06451081 | The University of Hong Kong | N/A |
| Completed | Room Air Levels of Harmful and Potentially Harmful Constituents After Heated Tobacco Product Use and Cigarette NCT06476405 | Altria Client Services LLC | — |
| Completed | Tobacco Cessation at FDNY NCT05997225 | Albert Einstein College of Medicine | Phase 4 |
| Recruiting | Development of a Smoking Cessation Video Series NCT06443294 | Wayne State University | N/A |
| Recruiting | INSPIRE Respiratory Health Program in Botucatu, São Paulo, Brazil NCT06673225 | UPECLIN HC FM Botucatu Unesp | — |
| Recruiting | Smoking Cessation Program in the Construction Sector NCT06098144 | University of Miami | Phase 4 |
| Completed | Human Perception of Odors and Odor Blockers NCT06191419 | Tim McClintock | N/A |
| Not Yet Recruiting | Episodic Future Thinking, Loss Aversion and Cigarette Smoking NCT05110612 | University of Vermont | N/A |
| Recruiting | Effectiveness of Combined Tobacco Treatment in Hospitalized Subjects NCT06254001 | National Institute of Respiratory Diseases, Mexico | Phase 4 |
| Enrolling By Invitation | Enhancing Equity in Smoke-free Housing NCT06042361 | Harvard School of Public Health (HSPH) | N/A |
| Unknown | Nicotine Replacement Therapy Sampling for Smokers in the Community NCT05881083 | The University of Hong Kong | N/A |
| Completed | Prevalence of Smoking After Lung Transplantation NCT07050004 | Fondation Hôpital Saint-Joseph | — |
| Recruiting | Effects of Post-isometric Relaxation Technique on Chest Expansion and Pulmonary Function Tests in Smokers NCT06444971 | Foundation University Islamabad | N/A |
| Completed | The Effects of Sedatives on Tobacco Use Disorder Version 2 NCT05505630 | Wake Forest University Health Sciences | EARLY_Phase 1 |
| Recruiting | App for Pregnancy Smoking Cessation With Peer Support NCT05337722 | Michigan State University | N/A |
| Active Not Recruiting | Potential Impact of Menthol Ban in Cigarettes and E-cigarettes NCT05259566 | Yale University | N/A |
| Recruiting | Smoking Cessation and Menstrual Cycle Phase NCT05515354 | Centre for Addiction and Mental Health | Phase 4 |
| Completed | Reduced Exposure to HPHC in Smokers Switching From Cigarettes to Different Versions of THS NCT05599451 | Philip Morris Products S.A. | N/A |
| Recruiting | Oral Cannabidiol for Tobacco Cessation NCT05445804 | Johns Hopkins University | Phase 1 |
| Completed | Dual Use Approach Bias Training for Nicotine Addiction NCT05306158 | University of Houston | N/A |
| Enrolling By Invitation | Persistent Poverty Counties Pregnant Women With Medicaid NCT05415371 | University of Oklahoma | N/A |
| Active Not Recruiting | Testing a School-Based E-cigarette, Tobacco, and Betel (Areca) Nut Use Prevention Curriculum for Guam Youths NCT05037656 | University of Guam | N/A |
| Completed | CSD200902: Assessment of Indoor Air Quality for a Heated Tobacco Product With Four Non-Combusted Cigarette Var NCT05363254 | RAI Services Company | N/A |
| Completed | CSD201301: Study to Assess Elements of Abuse Liability for Four P13 Nicotine Pouches NCT05294497 | RAI Services Company | N/A |
| Completed | CSD210903: A Study to Determine Subject Puffing Patterns of a Heated Tobacco Product With Four Non-Combusted C NCT05307822 | RAI Services Company | N/A |
| Completed | Accelerated Transcranial Magnetic Stimulation (TMS) for Smoking Cessation in People Living With HIV/AIDS (PLWH NCT05295953 | Gopalkumar Rakesh | N/A |
| Completed | CSD201201: Study to Assess Elements of Abuse Liability for Electronic Nicotine Delivery System P12 NCT05210699 | RAI Services Company | N/A |
| Completed | COPD E-cigarette Topography Training NCT05510154 | University of Kansas Medical Center | N/A |
| Completed | CSD201004: An Actual Use Study of P10 and P13 Nicotine Pouches Among U.S. Adult Smokers NCT05184920 | RAI Services Company | — |
| Completed | BAT3221032: A Study to Evaluate the Effects of Switching From Cigarette Smoking to Using One of Five Variants NCT05142436 | British American Tobacco (Investments) Limited | N/A |
| Completed | Pilot Testing a Computer Delivered Tobacco Cessation Intervention in Outpatient Clinical Settings: A Feasibili NCT05145738 | Johns Hopkins University | N/A |
| Completed | Heart Rate Variability Biofeedback for Smoking Cessation Treatment NCT05224050 | Rutgers, The State University of New Jersey | Phase 2 |
| Completed | CSD200907: A Study to Assess Elements of Abuse Liability for a Heated Tobacco Product With Four Non-Combusted NCT05114863 | RAI Services Company | N/A |
| Completed | CSD201001: Study to Assess Elements of Abuse Liability for Three Nicotine Pouches NCT05129657 | RAI Services Company | N/A |
| Completed | CSD210904: Study to Assess Actual Use of a Heated Tobacco Product With Four Non-Combusted Cigarette Variants i NCT05102786 | RAI Services Company | — |
| Completed | Comparing Nicotine Delivery, Subjective Effects, and Sensory Experiences of Tobacco Users Using Oral Nicotine NCT05030194 | Roswell Park Cancer Institute | N/A |
| Completed | Cigarette Smoking Decision Study NCT04595279 | Johns Hopkins University | N/A |
| Unknown | Strategies to Connect Patients at Federally Qualified Health Clinics With Evidence Based Tobacco Cessation Tre NCT03900767 | University of Utah | N/A |
| Completed | eCEASE to Support Treatment for Parental Tobacco Use NCT04974736 | Massachusetts General Hospital | N/A |
| Completed | Adapt2Quit - An Adaptive Motivational System for Socio-Economically Disadvantaged Smokers NCT04720625 | University of Massachusetts, Worcester | N/A |
| Completed | Financial Incentives for Homeless Smokers: A Community-based RCT NCT04445662 | Massachusetts General Hospital | N/A |
| Active Not Recruiting | The Effect of Tobacco Products on Wound Healing NCT04870970 | University of Minnesota | — |
| Completed | A Study to Characterize Nicotine Pharmacokinetics and Subjective Effects of Nicotine Pouches in Adult Cigarett NCT04846088 | British American Tobacco (Investments) Limited | N/A |
| Completed | Promoting Evidenced-Based Tobacco Smoking Cessation Treatment in Community Mental Health Clinics NCT04796961 | Johns Hopkins University | N/A |
| Completed | CSD210202: A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery Systems NCT04751461 | RAI Services Company | N/A |
| Completed | A Study to Assess the Pharmacokinetics of Oral Nicotine Pouches and Lozenges in Healthy Adults NCT04755348 | British American Tobacco (Investments) Limited | N/A |
| Completed | Smoking Reduction In Gravid Substance Use Disorders NCT04132232 | University of Alabama at Birmingham | N/A |
| Completed | STARS (Smoking Treatment And Remote Sampling) Study NCT04525755 | Medical University of South Carolina | Phase 1 / Phase 2 |
| Completed | Computer Delivered and Community Health Worker Supported Smoking Cessation Intervention NCT04566159 | Johns Hopkins University | N/A |
| Unknown | The Effect of Electronic Cigarette Use on Smoking Behaviors Among Smokers Receiving Outpatient Psychiatric Tre NCT04014322 | Fordham University | N/A |
| Completed | Acute Effects of TCIG vs ECIG in PLWH NCT04568395 | University of California, Los Angeles | N/A |
| Unknown | Project MARS: Mobile-Assistance for Regulating Smoking NCT04376489 | University of Utah | N/A |
| Completed | CSD190601: A Study to Determine Subject Puffing Patterns of Electronic Nicotine Delivery Systems in an Ambulat NCT04308434 | RAI Services Company | N/A |
| Completed | CSD190401: A Study to Assess Elements of Abuse Liability for Nicotine-containing Pouch Tobacco Products NCT04372290 | RAI Services Company | N/A |
| Completed | CSD190501: A Study to Determine Subject Puffing Patterns of an Electronic Nicotine Delivery System in an Ambul NCT04226404 | RAI Services Company | N/A |
| Completed | Brain Imaging in Tobacco Smokers During a Quit Attempt NCT04055467 | Johns Hopkins University | Phase 1 |
| Completed | Connecting Alaska Native People to Quit Smoking NCT03645941 | Mayo Clinic | N/A |
| Completed | Evaluating the Comparative Pharmacokinetics of Nicotine After Administration Via JUUL or Tobacco Cigarettes NCT04053868 | University of California, San Francisco | N/A |
| Completed | CSD190301: A Study to Assess Elements of Abuse Liability for Two Dissolvable Nicotine Lozenge Tobacco Products NCT04167384 | RAI Services Company | N/A |
| Terminated | Laboratory Screening of Lorcaserin for Alcohol Use Disorder NCT04396847 | The Mind Research Network | Phase 2 |
| Completed | CSD190203: A Study to Determine Subject Puffing Patterns of an Electronic Nicotine Delivery System in an Ambul NCT04104152 | RAI Services Company | N/A |
| Completed | Evaluating Selected Constituents in the Exhaled Breath Samples NCT04143256 | Juul Labs, Inc. | N/A |
| Completed | CSD190202: Study to Assess Elements of Abuse Liability for Two Electronic Nicotine Delivery Systems NCT04094363 | RAI Services Company | N/A |
| Terminated | Mindfulness Based Smoking Cessation Among Cancer Survivors NCT04038255 | University of Miami | Phase 4 |
| Completed | Characterize the Nicotine Uptake and Subjective Effects With Use of JUUL Electronic Nicotine Delivery Systems NCT04123041 | Juul Labs, Inc. | N/A |
| Completed | Changes in Biomarkers of Cigarette Smoke Exposure After Switching Either Exclusively or Partly to JUUL ENDS NCT04107779 | Juul Labs, Inc. | N/A |
| Completed | Promoting Smoking Cessation in Lung Cancer Screening Through Proactive Treatment NCT03612804 | VA Office of Research and Development | N/A |
| Completed | Heart Rate Variability Biofeedback for Smoking Cessation NCT03972137 | Rutgers, The State University of New Jersey | Phase 2 |
| Completed | Persistence Targeted Smoking Cessation in Serious Mental Illness (SMI) NCT03873337 | Rutgers, The State University of New Jersey | N/A |
| Completed | Acceptance and Commitment Therapy for Tobacco Cessation Among Psychiatric Partial Hospital Patients NCT03911960 | The Miriam Hospital | N/A |
| Completed | Short Messaging Service Program to Help Quit Smoking During Perioperative Period. NCT03839043 | Mayo Clinic | N/A |
| Completed | Recruitment Messages for Current Smokers Recently Diagnosed With Cancer NCT05471284 | University of Oklahoma | N/A |
| Active Not Recruiting | Nivolumab for the Reversal of Squamous Dysplasia in High Risk Current and Former Smokers NCT03347838 | University of Colorado, Denver | Phase 2 |
| Completed | A Study of Unfiltered Cigarettes Among Committed Smokers NCT03749876 | San Diego State University | N/A |
| Recruiting | Smoking Cessation With Varenicline in Schizophrenia: Antipsychotic-Induced Neurological Symptoms as Correlates NCT03495024 | Corporal Michael J. Crescenz VA Medical Center | Phase 4 |
| Completed | Clinical Study Comparing 7 ENDS Products and 1 Combustible Cigarette Using 2 Delivery Methods. NCT03700112 | Juul Labs, Inc. | N/A |
| Completed | An Extended Facebook Intervention for Young Sexual and Gender Minority Smokers NCT03553992 | University of California, San Francisco | N/A |
| Completed | Innovative Digital Therapeutic for Smoking Cessation NCT03694327 | My Digital Study | N/A |
| Completed | United States Pre-Market Tobacco Application Pharmacokinetics NCT03719391 | Juul Labs, Inc. | N/A |
| Completed | Using Non-invasive Brain Stimulation (tDCS) With Varenicline for Treating Tobacco Dependence NCT03841292 | Centre for Addiction and Mental Health | N/A |
| Completed | Testing the Decoy Effect to Increase Tobacco Treatment Uptake NCT04200157 | NYU Langone Health | — |
| Completed | A Study to Characterize Puff Topography With Use of JUUL 5% Electronic Nicotine Delivery Systems (ENDS) in Adu NCT03596034 | Juul Labs, Inc. | N/A |
| Completed | Comparing the Pharmacokinetics of Nicotine Salt Based ENDS in Healthy Smokers NCT03593239 | Juul Labs, Inc. | N/A |
| Completed | Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace NCT03272685 | University of Minnesota | Phase 3 |
| Completed | Tobacco and Socioeconomic Disadvantage NCT03620708 | Rutgers, The State University of New Jersey | Phase 4 |
| Completed | A Guided Imagery Tobacco Cessation Intervention Delivered by a Quit Line and Website NCT02968381 | University of Arizona | N/A |
| Completed | A Facebook Intervention for Young Sexual and Gender Minority Smokers NCT03259360 | University of California, San Francisco | N/A |
| Completed | Effects of Nature Exposure on Smoking Behavior NCT03716440 | University of Montana | N/A |
| Terminated | Electroretinogram: a New Human Biomarker for Smoking Cessation Treatment NCT03213418 | New York State Psychiatric Institute | N/A |
| Completed | Smoking Prevalence at a University Hospital NCT03268980 | Hospices Civils de Lyon | — |
| Completed | Effects of Prenatal Tobacco Smoke Exposure on Lung Function and Respiratory Epithelium Functionality in Newbor NCT03047967 | Institut National de la Santé Et de la Recherche Médicale, France | N/A |
| Completed | EVarQuit: Extended Pre-quit Varenicline to Assist in Quitting Smoking NCT03262662 | State University of New York at Buffalo | Phase 3 |
| Completed | Pragmatic Randomised Controlled Trial Evaluating Effectiveness of a Smoking Cessation e- Intervention " Tabac NCT02841683 | Ecole des Hautes Etudes en Santé Publique | N/A |
| Completed | Development of a Tailored Smoking Cessation Program for Individuals With HIV Infection in Washington, D.C. NCT04594109 | Colorado State University | N/A |
| Completed | Helping Poor Smokers Quit NCT03194958 | Washington University School of Medicine | N/A |
| Completed | Financial Incentives to Reduce Pediatric Tobacco Smoke Exposures NCT03099811 | Johns Hopkins University | N/A |
| Completed | Evaluation of a Brief Tobacco Intervention in the US Military NCT03196102 | University of Virginia | N/A |
| Withdrawn | Investigation of the Impact of Smoking Status on Allergen-induced Nasal Airway Inflammation Using a Cat Hair ( NCT03031145 | University of North Carolina, Chapel Hill | Phase 1 |
| Completed | A Study of Tobacco Smoke and Children With Respiratory Illnesses NCT03062709 | MaineHealth | N/A |
| Completed | Developing Smokers for Smoker (S4S): A Collective Intelligence Tailoring System NCT02265354 | University of Massachusetts, Worcester | N/A |
| Completed | Cognitive and Emotional Skills to Aid Smoking Prevention NCT03058991 | Boston University Charles River Campus | N/A |
| Completed | E-cigarettes to Promote Smoking Reduction Among Individuals With Schizophrenia NCT02918630 | The University of Texas Health Science Center, Houston | N/A |
| Completed | Pilot Study of Contingency Management for Smoking Cessation NCT03015597 | King's College London | N/A |
| Completed | Air Quality Feedback to Reduce Second-hand Smoke (SHS) Exposure in the Home NCT03151421 | Institut Català d'Oncologia | N/A |
| Completed | EHR-Based and Fax-Based Referral to a Tobacco Quitline: A Comparative Study NCT02735382 | University of Wisconsin, Madison | N/A |
| Completed | Effects of Intranasal Oxytocin on Cigarette Smoking NCT02595749 | University of Southern California | Phase 4 |
| Completed | CSD1601: A Study to Evaluate the Exposure to Tar and Nicotine From Two Cigarette Products That Contain a Menth NCT04529551 | RAI Services Company | N/A |
| Completed | Effect of Packaging on Smoking Perceptions and Behavior NCT02676193 | University of California, San Diego | N/A |
| Completed | Investigation of Kava Effects on NNK Metabolism NCT02500472 | Masonic Cancer Center, University of Minnesota | N/A |
| Completed | Family Smoking Cessation in Romania Using Pregnancy as a Window of Opportunity NCT02512913 | Michigan State University | N/A |
| Completed | Methods Project 4: Clinical Trial - Amended NCT03111537 | University of Minnesota | N/A |
| Completed | Enhancing Smoking Cessation in the Homeless Population NCT01932996 | University of Minnesota | Phase 4 |
| Completed | Neurophysiological and Immunological Effects of the Transition From Combustible to Electronic Cigarettes NCT02433015 | Laureate Institute for Brain Research, Inc. | N/A |
| Completed | Project 2: Strategies for Reducing Nicotine Content in Cigarettes NCT02139930 | Wake Forest University Health Sciences | N/A |
| Completed | Behavioral Interventions to Target Self-Control NCT02281942 | Oregon Health and Science University | N/A |
| Unknown | Cardiovascular Risk Factors And Intensive Dietary Counselling NCT02173600 | Andalusian Regional Ministry of Health | N/A |
| Completed | Exercise for Depressed Smokers NCT02086149 | Butler Hospital | N/A |
| Unknown | Computer Tailored Program for Smoking Cessation Among Romanian Adults NCT02028962 | Iuliu Hatieganu University of Medicine and Pharmacy | N/A |
| Completed | Smoking Cessation for Young Adult Pacific Islanders: Motivating Pacifika Against Cigarettes and Tobacco NCT03238456 | Claremont Graduate University | N/A |
| Completed | Evaluation of National Cancer Institute Young Adult Stop-Smoking Program NCT01885052 | National Cancer Institute (NCI) | Phase 2 |
| Unknown | N-acetylcysteine for Tobacco Smoking NCT02124525 | Universidade Estadual de Londrina | Phase 3 |
| Completed | Decision Support for Smoking Cessation in Young Adults With Severe Mental Illness NCT01779440 | Dartmouth-Hitchcock Medical Center | N/A |
| Completed | Comparative Effectiveness of Post-Discharge Strategies for Hospitalized Smokers NCT01714323 | Massachusetts General Hospital | N/A |
| Unknown | Effects of Intensive Behavioral Training Program on Impulsivity and Inhibitory Control in Smokers NCT01314378 | Massachusetts General Hospital | N/A |
| Completed | Developing Genetic Education for Smoking Cessation NCT01186016 | University of Nebraska | N/A |
| Unknown | Working Inside for Smoking Elimination NCT01122589 | Memorial Hospital of Rhode Island | N/A |
| Completed | Mindfulness Training for Smoking Cessation NCT01144689 | Yale University | N/A |
| Completed | Trial Comparing Different Methods of Support With Stopping Smoking (PORTSSS/Stop Together Trial) NCT00775944 | University of Nottingham | Phase 4 |
| Completed | Study of Bronchial Inflammation in Adolescent Smokers With and Without Obesity NCT00942019 | Johann Wolfgang Goethe University Hospital | — |
| Completed | Intranet-based Tobacco Prevention Program for Children NCT00680875 | Oregon Research Institute | N/A |
| Completed | Evaluation of the Media Detective Program for Elementary School-Aged Children to Prevention Substance Use NCT01060852 | Innovation Research & Training | N/A |
| Completed | Effectiveness of Intensive Smoking Cessation Interventions in Patients With Cancer NCT04198688 | Bispebjerg Hospital | — |
| Unknown | Smoking Interventions in the General Population NCT00678938 | University Medicine Greifswald | Phase 2 |
| Unknown | Smoking Interventions in General Medical Practices NCT00679861 | University Medicine Greifswald | Phase 2 |
| Unknown | Healthy Outcomes of Pregnancy Education NCT00381823 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Phase 2 |