NCT04071119

Alcohol and Cigarette Craving During Oxytocin Treatment

The Neural Mechanisms Associated With Alcohol and Cigarette Craving in Alcohol Use Disorder Smokers During Oxytocin Treatment

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 19 (actual)
• Sponsor: Brown University · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

This proposed research seeks to examine the behavioral and neural substrates of intranasal oxytocin compared to placebo on alcohol cue-induced alcohol and cigarette craving smokers with an alcohol use disorder (AUD). Non treatment-seeking smokers with an AUD will be recruited to participate in a between-subjects, placebo-controlled, randomized pilot functional magnetic resonance imaging (fMRI) study. Participants will undergo an fMRI scan in conjunction with an alcohol-olfactory cue-reactivity task. Secondary assessments will include alcohol and cigarette craving, alcohol and cigarette consumption, physiological measures (heart rate and blood pressure) and mood measures.

Conditions

• Alcohol Use Disorder
• Smoking

Interventions

Type	Name	Description
DRUG	Oxytocin nasal spray	Participants administer the oxytocin (40 IU) twice a day for 5 - 7 days
DRUG	Placebo	Participants administer the placebo (40 IU) twice a day for 5 - 7 days

Timeline

• Start date: 2020-11-09
• Primary completion: 2024-04-02
• Completion: 2024-04-02
• First posted: 2019-08-28
• Last updated: 2024-05-14

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study