NCT03185546

Project 2 Cigarette and E-cigarette Nicotine Content and E-liquid Flavors

Project 2: The Impact of Cigarette Nicotine Content, E-cigarette Nicotine Content, and E-cigarette Flavoring on Smoking Behavior

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 156 (actual)
• Sponsor: Wake Forest University Health Sciences · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Project 2 will evaluate the impact of very low nicotine content cigarettes, e-cigarette nicotine content, and e-cigarette flavoring on cigarettes smoked per day, nicotine exposure, puff topography, discomfort/dysfunction, other health-related behaviors, nicotine/tobacco dependence, biomarkers of tobacco exposure, intention to quit, compensatory smoking, other tobacco use, cardiovascular function, and perceived risk. Project 2 will also evaluate differences between conditions in compliance with product use and the ability to abstain from cigarette smoking when provided a financial incentive for abstinence from combusted tobacco. This is not a treatment program for smoking.

Conditions

• Smoking

Interventions

Type	Name	Description
OTHER	NNC Spectrum Cigarette	Participants are provided with normal nicotine content Spectrum Cigarette for 13 weeks.
OTHER	VLNC Spectrum Cigarette	Participants are provided with very low nicotine content Spectrum Cigarette for13 weeks
OTHER	Moderate nicotine level e-liquid	Participants are provided with moderate nicotine level e-liquid for 13 weeks
OTHER	Low nicotine level e-liquid	Participants are provided with very low or nicotine-free nicotine level e-liquid for 13 weeks
OTHER	Tobacco Flavors	Participants can choose e-liquid flavors from a selection of tobacco flavors
OTHER	Tobacco and non-tobacco e-liquid flavors	Participants can choose e-liquid flavors from a selection of flavors that includes tobacco and non-tobacco choices

Timeline

• Start date: 2018-08-06
• Primary completion: 2020-03-13
• Completion: 2020-03-13
• First posted: 2017-06-14
• Last updated: 2021-05-14
• Results posted: 2021-05-14

Locations

2 sites across 1 country: United States