NCT04133376

Electronic Hookah and Endothelial Cell Function

The Effects of Electronic Hookah on Endothelial Cell Function: The Role of Nicotine

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 33 (actual)
• Sponsor: University of California, Los Angeles · Academic / Other
• Sex: All
• Age: 21 Years – 39 Years
• Healthy volunteers: Accepted

Summary

Electronic nicotine delivery systems (ENDS) are a rapidly growing global epidemic among adolescents and young adults. Unlike other ENDS such as e-cigarettes, e-hookahs are used through traditional water-pipes, allowing the vapor-containing nicotine, propylene glycol, glycerin, and flavorings-to pass through a water-filled basin, potentially altering the vapor, before it is inhaled through the user's mouth. Contributing to e-hookahs popularity is the belief that the flavored smoke is detoxified as it passes through the water-filled basin, rendering e-hookah a safer tobacco alternative. However, an e-hookahs deliver flavored nicotine by creating a vapor of fine particles and volatile organic compounds that could induce vascular toxicity. While e-hookah vaping acutely reduces endothelial function, the specific role of nicotine and the mechanisms by which it may impairs endothelial function remain understudied. The objective of this project is to investigate the specific role of nicotine in mediating the acute effects of e-hookah vaping on endothelial dysfunction.

Conditions

• Smoking
• Endothelial Dysfunction

Interventions

Type	Name	Description
OTHER	Electronic hookah vaping with nicotine	Participants will be invited to vape a 30-minute session of e-hookah containing nicotine
OTHER	Electronic hookah vaping without nicotine	Participants will be invited to vape a 30-minute session of e-hookah without containing nicotine

Timeline

• Start date: 2020-01-16
• Primary completion: 2022-11-29
• Completion: 2023-05-29
• First posted: 2019-10-21
• Last updated: 2026-03-12

Locations

1 site across 1 country: United States