NCT06991062

Bayesian Neurobehavioral Phenotyping: From Mechanism Identification to Personalized Neuromodulation Treatments. R61 PHASE

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: M.D. Anderson Cancer Center · Academic / Other
• Sex: All
• Age: 21 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical research study is to learn more about whether individual differences in brain responses to emotional triggers impact rTMS (repetitive transcranial magnetic stimulation) responses in people who smoke.

Detailed description

Primary Objectives: 1. Determine the extent to which neuroaffective individual differences moderate rTMS treatment effects. Our working hypothesis is that smokers characterized by the LPP+ profile will be more likely to reduce nicotine self-administration after inhibitory rTMS to the VMPFC than after excitatory rTMS to the DLPFC. 2. Determine the extent to which neurocognitive individual differences moderate rTMS treatment effects. Our working hypothesis is that smokers characterized by the θ+ profile will be more likely to reduce nicotine self-administration after excitatory rTMS to the DLPFC than after inhibitory rTMS to the VMPFC. Exploratory Objectives: Our long-term goal is to develop image-guided, personalized rTMS interventions. Carefully assessing the time required for each step in the protocol will allow us to identify opportunities to further optimize our procedures and reduce visit duration in our future studies. We will measure: 1. The time required by the staff to conduct each ERP assessment. 2. The time between the end of the last rTMS session and the start of the second ERP assessment. We will analyze each measure to obtain an accurate estimate of the duration of each step in the procedures.

Conditions

• Smoking

Interventions

Type	Name	Description
PROCEDURE	Repetitive Transcranial Magnetic Stimulation (rTMS)	TMS is a non-invasive procedure in which a coil is placed over the scalp, and focused magnetic pulses are applied to parts of the brain through the coil.

Timeline

• Start date: 2025-02-19
• Primary completion: 2026-12-01
• Completion: 2028-12-01
• First posted: 2025-05-25
• Last updated: 2026-01-26

Locations

1 site across 1 country: United States