NCT03272295

A Nicotine Pharmacokinetics and Smoking Behaviour Study Examining Cigarette Ingredients

A Randomised, Controlled, Double-Blind Study to Examine Nicotine Pharmacokinetics and Smoking Behaviour in Healthy Smokers When Smoking Cigarettes Containing Different Commonly Used Ingredients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: British American Tobacco (Investments) Limited · Industry
• Sex: All
• Age: 21 Years – 55 Years
• Healthy volunteers: Accepted

Summary

This study will compare nicotine delivery and smoking behaviour in healthy subjects using several combustible cigarette prototypes containing different ingredients which are commonly used in the European Union.

Conditions

• Healthy Volunteers
• Smoking

Interventions

Type	Name	Description
OTHER	Reference cigarette	The reference product is based on a commercially-available king-size cigarette design (length 83 mm, circumference 24.6 mm) with a single segment cellulose acetate filter and tobacco blend recipe without ingredients.
OTHER	Cigarette with carob bean extract	Based on reference cigarette with added ingredient
OTHER	Cigarette with cocoa powder	Based on reference cigarette with added ingredient
OTHER	Cigarette with fenugreek extract	Based on reference cigarette with added ingredient
OTHER	Cigarette with fig juice	Based on reference cigarette with added ingredient
OTHER	Cigarette with glycerol	Based on reference cigarette with added ingredient
OTHER	Cigarette with guaiacol	Based on reference cigarette with added ingredient
OTHER	Cigarette with liquorice extract powder	Based on reference cigarette with added ingredient
OTHER	Cigarette plus I-menthol	Based on reference cigarette with added ingredient
OTHER	Cigarette with propylene glycol	Based on reference cigarette with added ingredient
OTHER	Cigarette with sorbitol	Based on reference cigarette with added ingredient
OTHER	Cigarette with multiple ingredients	Based on reference cigarette plus propylene glycol, glycerol, liquorice extract powder, cocoa powder, carob bean extract, fig juice concentrate, maltol, guaiacol, geraniol, fenugreek extract.

Timeline

• Start date: 2017-09-12
• Primary completion: 2017-12-08
• Completion: 2017-12-08
• First posted: 2017-09-05
• Last updated: 2022-12-07

Locations

1 site across 1 country: United Kingdom