NCT06920849

Evaluation of the Influence of PRF (Platelet-rich Fibrin) on the Clinical Parameters and the Concentration of Selected Inflammation Mediators in GCF (Gingival Crevice Fluid) of Patients With Periodontitis

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Medical University of Bialystok · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Assessment of the influence of injectable platelet-rich fibrin (i-PRF) on the clinical parameters and the inflammation mediators levels in the gingival crevicular fluid (GCF) in patients with periodontitis.

Detailed description

Forty subjects diagnosed with periodontitis were randomly divided into two groups. In the test group, SRP was performed with the subsequent application of iPRF into periodontal pockets, while in the control group SRP was performed alone. Clinical examination was performed before and 1, 3 and 6 months after treatment. For inflammation mediators levels determination in GCF samples ELISA method will be used.

Conditions

• Periodontal Disease
• Periodontitis

Interventions

Type	Name	Description
BIOLOGICAL	SRP+iPRF	SRP (scaling and root planing) with iPRF (injectable platelet-rich fibrin)
PROCEDURE	SRP	SRP (scaling and root planing)

Timeline

• Start date: 2022-04-01
• Primary completion: 2025-06-30
• Completion: 2025-06-30
• First posted: 2025-04-10
• Last updated: 2025-04-10

Locations

1 site across 1 country: Poland