NCT07013162

Efficacy of Laser Therapy for Periodontitis

Efficacy of Diode Laser and Non-Surgical Periodontal Therapy in the Treatment of Periodontitis: A Clinical and Immunological Study

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 21 (estimated)
• Sponsor: University of Science and Technology, Yemen · Academic / Other
• Sex: All
• Age: 25 Years – 58 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to evaluate the efficacy of diode laser in addition to periodontal treatment in periodontitis patients and to investigate their effects on gingival crevicular fluid (GCF) cytokine levels before and after treatment, among some Yemeni individuals in Sana'a city.

Detailed description

This study aims to compare the clinical and immunological effects of traditional mechanical debridement alone versus combined treatment with diode laser (high and low power). The clinical parameters include Plaque Index (PI), Gingival Index (GI), Periodontal Pocket Depth (PPD), and Clinical Attachment Loss (CAL). Immunological parameters include IL-1β, IL-6, IL-8, and TNF-α levels in GCF. Participants will be selected from the Yemeni population residing in Sana'a City. The study will include a control group receiving conventional therapy and two test groups receiving diode laser therapy with high and low intensity settings, respectively. Measurements will be recorded at baseline (T0), one month after treatment (T1), and three months post-treatment (T2). The goal is to determine whether adjunctive diode laser therapy provides additional clinical and immunological benefits compared to conventional treatment alone.

Conditions

• Periodontal Disease

Interventions

Type	Name	Description
PROCEDURE	High power diode laser + SRT	2W laser will be applied to periodontal pockets
PROCEDURE	Low diode diode laser + SRT	A 0.5W low laser is applicated to periodontal pockets after mechanical debridement
PROCEDURE	Curettage (SRT) only	Mechanical debridement for pocket

Timeline

• Start date: 2025-07-01
• Primary completion: 2026-06-01
• Completion: 2026-08-01
• First posted: 2025-06-10
• Last updated: 2025-06-10