| Not Yet Recruiting | Catestatin as a Novel Biomarker for Cardiovascular and Microvascular Involvement in Systemic Sclerosis NCT07209644 | Assiut University | — |
| Suspended | Study to Evaluate the Safety, Tolerability, and Activity of CM-101 in Patients With Systemic Sclerosis NCT06210945 | ChemomAb Ltd. | Phase 2 |
| Not Yet Recruiting | A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis NCT07497087 | Boehringer Ingelheim | Phase 3 |
| Not Yet Recruiting | Immun4Cure Cohort of Autoimmune Diseases NCT07515638 | University Hospital, Montpellier | — |
| Not Yet Recruiting | A Study to Compare the Efficacy and Safety of BMS-986353 (Zolacaptagene- Autoleucel / Zola-cel), CD19-CAR T Ce NCT07335562 | Juno Therapeutics, Inc., a Bristol-Myers Squibb Company | Phase 3 |
| Recruiting | Umbilical Cord Blood CD19-BCMA CART Cell Therapy for SLE-LN, SSc, andpSS PAH. NCT06947473 | Beijing GoBroad Hospital | Phase 1 / Phase 2 |
| Recruiting | Autologous Stem Cell Transplant (ASCT) for Autoimmune Diseases NCT05029336 | Stephan Grupp MD PhD | Phase 2 |
| Recruiting | A Study of Nemolizumab for the Treatment of Adults With Systemic Sclerosis NCT07047690 | Galderma R&D | Phase 2 |
| Recruiting | Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA U CAR-T Cell Injection for the Treatm NCT07246096 | Changhai Hospital | EARLY_Phase 1 |
| Not Yet Recruiting | A Study of CD19 UCAR-T Cells in Subjects With Autoimmune Diseases NCT07212322 | Institute of Hematology & Blood Diseases Hospital, China | N/A |
| Recruiting | A Study of AZD0120 in Autoimmune Diseases NCT07295847 | AstraZeneca | Phase 1 |
| Not Yet Recruiting | Evaluating Tools to Communicate Scleroderma Research Results to Patients - Trial #1 NCT06373263 | Lady Davis Institute | N/A |
| Recruiting | Exploratory Clinical Study on YTS109 Cell Therapy for Autoimmune Diseases NCT07236801 | China Immunotech (Beijing) Biotechnology Co., Ltd. | Phase 1 |
| Recruiting | A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in A NCT07085104 | Allogene Therapeutics | Phase 1 |
| Not Yet Recruiting | EACVI Study on Multimodality Cardiovascular Imaging of Inflammatory Cardiovascular Diseases NCT07077304 | Assistance Publique - Hôpitaux de Paris | — |
| Not Yet Recruiting | Exploring the Patterns of Sleep Disordered Breathing in Systemic Sclerosis Patients NCT07175246 | Assiut University | — |
| Enrolling By Invitation | A Study of KITE-363 in Participants With Refractory Autoimmune Diseases NCT07038447 | Kite, A Gilead Company | Phase 1 |
| Recruiting | Study of the Efficacy of Nintedanib+Tocilizumab in Patients With Systemic Sclerosis and Interstitial Lung Dise NCT06297096 | National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland | Phase 3 |
| Not Yet Recruiting | Early Clinical Study of UTAA91 Injection for the Treatment of Relapsed/Refractory Autoimmune Diseases NCT06970951 | PersonGen BioTherapeutics (Suzhou) Co., Ltd. | EARLY_Phase 1 |
| Not Yet Recruiting | UCAR T-cell Therapy Targeting CD19/ BCMA in Patients With Relapse/ Refractory Autoimmune Diseases NCT06978738 | Changzhou No.2 People's Hospital | Phase 1 |
| Active Not Recruiting | A Phase 1 Study of SYNCAR-001 + STK-009 Without Conditioning Chemotherapy (Lymphodepletion) in Subjects With S NCT06544330 | Synthekine | Phase 1 |
| Recruiting | CD19-BCMA CART Cell Therapy for Refractory SLE-LN, SSc, and pSS-PAH NCT06947460 | Beijing GoBroad Hospital | Phase 1 / Phase 2 |
| Active Not Recruiting | UCAR T-cell Therapy Targeting CD19/ BCMA in Patients With Relapse/ Refractory Autoimmune Diseases NCT07155369 | The Affiliated Hospital of Xuzhou Medical University | N/A |
| Recruiting | A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease NCT06925542 | CRISPR Therapeutics | Phase 1 |
| Enrolling By Invitation | Mesenchymal Stem Cells Infusion in Patients With Autoimmune Diseases NCT06888973 | National Institute of Blood and Marrow Transplant (NIBMT), Pakistan | Phase 1 / Phase 2 |
| Completed | Self-Guided Resilience-Building Energy Management to Enhance Well-being (RENEW) Intervention for People With S NCT07402863 | University of Michigan | N/A |
| Recruiting | Clinical Study on Targeted CD19/BCMA CAR-T Therapy for Autoimmune Diseases NCT06775912 | Nanjing Bioheng Biotech Co., Ltd. | EARLY_Phase 1 |
| Recruiting | A Phase 1/2 Study of NKX019 in Subjects With Immune-Mediated Diseases (Ntrust-2) NCT06733935 | Nkarta, Inc. | Phase 1 / Phase 2 |
| Enrolling By Invitation | Chest CT Biomarkers as Prognostic Predictors in SSc-ILD NCT06472362 | Royal Brompton & Harefield NHS Foundation Trust | — |
| Recruiting | Clinical Study on Targeted CD19 or CD19-BCMA CAR-T Therapy for Autoimmune Diseases NCT06548607 | Nanjing Bioheng Biotech Co., Ltd. | EARLY_Phase 1 |
| Suspended | Clinical Study on Targeted CD19CAR-T Therapy for Autoimmune Diseases NCT06549296 | Nanjing Bioheng Biotech Co., Ltd. | EARLY_Phase 1 |
| Not Yet Recruiting | Evaluation of Patients With Systemic Sclerosis Without Specific or Associated Autoantibodies NCT06412614 | Central Hospital, Nancy, France | — |
| Recruiting | Mycophenolate Mofetil in Systemic Sclerosis With Subclinical Interstitial Lung Disease NCT05785065 | Centre hospitalier de l'Université de Montréal (CHUM) | Phase 2 |
| Active Not Recruiting | KYSA-5: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in Subjects With Systemic NCT06400303 | Kyverna Therapeutics | Phase 1 / Phase 2 |
| Recruiting | Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Aut NCT06434363 | M.D. Anderson Cancer Center | Phase 1 / Phase 2 |
| Recruiting | Fourth-gen CAR T Cells Targeting BCMA/CD19 for Refractory Systemic Lupus Erythematosus (SLE) NCT06350110 | Essen Biotech | Phase 1 / Phase 2 |
| Recruiting | RESET-SSc: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201, a CD19-CAR T Cell Therapy, in NCT06328777 | Cabaletta Bio | Phase 1 / Phase 2 |
| Recruiting | Integration of Remote Monitoring in the Management of Chronic Immunosuppressive Therapy NCT06544343 | University Of Perugia | N/A |
| Not Yet Recruiting | 89Zr-Oxine-RY_SW01 Cell Injection for the Treatment of Systemic Sclerosis NCT06489652 | Jiangsu Renocell Biotech Company | Phase 1 |
| Recruiting | Relmacabtagene Autoleucel for the Treatment of Systemic Sclerosis NCT06414135 | Liangjing Lu | Phase 1 |
| Recruiting | The Safety and Efficacy of Telitacicept in the Treatment of Systemic Sclerosis NCT06546540 | Peking University Third Hospital | Phase 4 |
| Not Yet Recruiting | The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refractory Autoimmune Diseases NCT06420154 | First Affiliated Hospital of Wenzhou Medical University | EARLY_Phase 1 |
| Not Yet Recruiting | Preliminary Clinical Study of UTAA09 Injection in the Treatment of Relapsed/Refractory Autoimmune Diseases NCT06417398 | PersonGen BioTherapeutics (Suzhou) Co., Ltd. | EARLY_Phase 1 |
| Recruiting | Color Doppler Ultrasonography Evaluation of Abdominal and Peripheral Vasculopathy in Systemic Sclerosis Patien NCT07012655 | Assiut University | — |
| Recruiting | An Clinical Study of YTS109 Cell Injection in Subjects With Recurrent/Refractory Autoimmune Disease NCT06379646 | China Immunotech (Beijing) Biotechnology Co., Ltd. | N/A |
| Recruiting | Anti-CD19-CD3E-CAR-T Cells in Relapsed/Refractory Autoimmune Disease NCT06373081 | Shanghai Changzheng Hospital | N/A |
| Recruiting | Hand Function Impairment in Systemic Sclerosis: Outcomes, Mechanisms and Experience (HANDSOME) NCT06133244 | UMC Utrecht | — |
| Recruiting | Personalized Home Respiratory Rehabilitation Program for Subjects With Systemic Sclerosis With Early Lung Dise NCT05533034 | Assistance Publique - Hôpitaux de Paris | N/A |
| Recruiting | Early Clinical Study of UTAA09 Injection in the Treatment of Relapsed/Refractory Autoimmune Diseases NCT06361745 | PersonGen BioTherapeutics (Suzhou) Co., Ltd. | N/A |
| Active Not Recruiting | Faecal Microbiota Transplantation Against Chronic Diarrhea in Patients With Systemic Sclerosis NCT06333795 | University of Aarhus | N/A |
| Recruiting | Interrogating the Pathophysiological Mechanisms of Constipation in Patients With Systemic Sclerosis NCT05989763 | The University of Texas Health Science Center, Houston | N/A |
| Unknown | Safety and Efficacy of Topical Sodium Metabisulfite for the Treatment of Calcinosis in Patients With Systemic NCT06155578 | Pontificia Universidad Catolica de Chile | Phase 1 / Phase 2 |
| Recruiting | Evaluation of Muscle Involvement in Systemic Sclerosis NCT06051773 | Central Hospital, Nancy, France | — |
| Recruiting | Neutrophil Extracellular Traps in Different Forms of Systemic Sclerosis NCT06462768 | CHU de Reims | — |
| Completed | Early Diagnosis of SSc in the General Rheumatology Clinic - Pilot NCT06291142 | University of Manchester | — |
| Completed | A Study of MK-2225 in Healthy Participants (MK-2225-003) NCT06643390 | Merck Sharp & Dohme LLC | Phase 1 |
| Active Not Recruiting | Determine Effectiveness of Anifrolumab In SYstemic Sclerosis (DAISY) NCT05925803 | AstraZeneca | Phase 3 |
| Recruiting | Safety and Efficacy Study of CD19-CAR-DNT Cells in Autoimmune Diseases NCT06316076 | RenJi Hospital | Phase 1 |
| Recruiting | RY_SW01 Cell Injection Therapy in Systemic Sclerosis NCT06058091 | Jiangsu Renocell Biotech Company | Phase 1 / Phase 2 |
| Recruiting | A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Dise NCT05869955 | Juno Therapeutics, Inc., a Bristol-Myers Squibb Company | Phase 1 |
| Unknown | Manufacturing of Allogeneic Adipose Tissue-derived Mesenchymal Stromal Cells for Treatment of Severe Systemic NCT05947682 | Assistance Publique - Hôpitaux de Paris | N/A |
| Not Yet Recruiting | Calcinosis Reduction by Pyrophosphate in SSC NCT04966416 | Szeged University | N/A |
| Recruiting | CAR-T Cells in Systemic B Cell Mediated Autoimmune Disease NCT06347718 | Miltenyi Biomedicine GmbH | Phase 1 / Phase 2 |
| Unknown | Acceptance and Effectiveness of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) Vaccination in Sy NCT05960058 | Assistance Publique - Hôpitaux de Paris | — |
| Active Not Recruiting | Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases NCT05879419 | University of Sao Paulo General Hospital | Phase 4 |
| Enrolling By Invitation | Universal CAR-T Cells (BRL-301) in Relapse or Refractory Autoimmune Diseases NCT05859997 | Bioray Laboratories | N/A |
| Recruiting | Interstitial Lung Disease Trajectories in Patients With Systemic Sclerosis NCT05345795 | Central Hospital, Nancy, France | — |
| Not Yet Recruiting | Implementation of a Biological Sample Collection in Systemic Sclerosis Patients NCT04986514 | University Hospital, Lille | — |
| Active Not Recruiting | Rheumatology-based Adaptive Intervention for Social Determinants and Health Equity NCT05715463 | Brigham and Women's Hospital | N/A |
| Recruiting | Safety and Efficacy of Itacitinib in Adults With Systemic Sclerosis NCT04789850 | Assistance Publique - Hôpitaux de Paris | Phase 2 |
| Completed | A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of RO7303509 in Participants With Systemic NCT05462522 | Genentech, Inc. | Phase 1 |
| Recruiting | Evaluation of HRCT Patterns in Systemic Sclerosis-associated Interstitial Lung Disease NCT05482607 | Central Hospital, Nancy, France | — |
| Terminated | RIC alloBMT With Post-transplant Cyclophosphamide for Refractory Systemic Sclerosis NCT05298358 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Phase 1 |
| Completed | Effectiveness of Cannabinoids on Appetite in Scleroderma NCT05416697 | Khon Kaen University | Phase 3 |
| Terminated | Efficacy and Safety of Riociguat in Incipient Pulmonary Vascular Disease as an Indicator for Early PAH NCT05339087 | Heidelberg University | Phase 2 |
| Recruiting | Nitric Oxide Lung Diffusing Capacity in Systemic Sclerosis NCT05505617 | Holger Dressel | — |
| Unknown | Sleep Quality, Stress, Depression, Blood Pressure Responses to Diaphragmatic Respiratory Exercise in Systemic NCT05623917 | Cairo University | N/A |
| Recruiting | Prospective Cohort of Patients With Systemic Sclerosis at Brest University Hospital With Biobanking NCT05532865 | University Hospital, Brest | — |
| Unknown | Efficacy of a Personalized Rehabilitation Program of Facial Involvement in Systemic Sclerosis NCT05177380 | University Hospital, Strasbourg, France | N/A |
| Unknown | Sirtuin 3 and Sirtuin 7 in Systemic Sclerosis NCT04303208 | Assiut University | N/A |
| Unknown | Treatment of Systemic Sclerosis With Autologous Regulatory Т-cells NCT05214014 | Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus | Phase 1 / Phase 2 |
| Active Not Recruiting | A Study of MT-0551 in Patients With Systemic Sclerosis NCT05198557 | Tanabe Pharma Corporation | Phase 3 |
| Recruiting | Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell IV Infusion for Systemic Scle NCT05016804 | The Foundation for Orthopaedics and Regenerative Medicine | Phase 1 |
| Recruiting | Preventive Effect of Clopidogrel on the Systemic Sclerosis Development Risk NCT05098704 | University Hospital, Bordeaux | Phase 2 / Phase 3 |
| Recruiting | Analysis of Dermal Fibroblasts and Immune Cells During Systemic Sclerosis NCT05273138 | University Hospital, Lille | — |
| Completed | Occupational and Environmental Causes of Autoimmune Diseases NCT07000903 | Université Catholique de Louvain | N/A |
| Completed | An Open-label, Phase 2 Study to Assess the Efficacy and Safety of Nemolizumab in Subjects With Systemic Sclero NCT05214794 | Maruho Co., Ltd. | Phase 2 |
| Completed | Ultrasound Therapy and Manual Therapy in Digital Ischemic Ulcers NCT05907200 | University of Palermo | N/A |
| Completed | Klotho and Mineral Bone Density in Systemic Sclerosis NCT05777954 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Unknown | COvid-19 Vaccine Booster in Immunocompromised Rheumatic Diseases NCT05236491 | Paul R Fortin | Phase 2 / Phase 3 |
| Active Not Recruiting | A Study Evaluating the Efficacy and Safety of Baricitinib in Systemic Sclerosis NCT05300932 | Tongji Hospital | Phase 4 |
| Unknown | Rheopheresis for Raynaud's and Digital Ulcers in Systemic Sclerosis NCT05204784 | Peter Korsten | N/A |
| Unknown | Systemic Sclerosis and Innate T Cells NCT04995588 | Poitiers University Hospital | N/A |
| Completed | The Effect of Cognitive Exercise Therapy Approach in Individuals With Systemic Sclerosis NCT05453071 | Hacettepe University | N/A |
| Withdrawn | Efficacy and Safety of JAK Inhibitors in Systemic Sclerosis-associated Interstitial Lung Disease NCT05177471 | Central Hospital, Nancy, France | — |
| Unknown | Stem Cell Factor, a Potential Biological Marker of Skin Involvement in Systemic Sclerosis? NCT05482594 | Brugmann University Hospital | — |
| Unknown | What is the Optimal Follow-up for Patients With Systemic Sclerosis? NCT05103553 | Leiden University Medical Center | N/A |
| Unknown | Mycophenolate in Limited Cutaneous Systemic Sclerosis (MINIMISE-Pilot) NCT04927390 | University College, London | Phase 2 |
| Enrolling By Invitation | PET Imaging of Systemic Sclerosis Using FDG and 68Ga-DOTA-Siglec-9 NCT05108857 | Turku University Hospital | — |
| Recruiting | Search for Diagnostic and Prognostic Biomarkers in Systemic Sclerosis and Inflammatory Myopathies NCT04917705 | University Hospital, Strasbourg, France | N/A |
| Completed | Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Digestive Symptoms in Systemic Sclerosis Systemi NCT04971018 | University Hospital, Grenoble | N/A |
| Recruiting | Mesenchymal Stromal Cells as Treatment for Digital Ulcers in Systemic Sclerosis NCT03211793 | UMC Utrecht | Phase 1 / Phase 2 |
| Completed | SPIN Self-Management Feasibility Trial With Progression to Full-scale Trial (SPIN-SELF) NCT04246528 | Lady Davis Institute | N/A |
| Completed | Exercise in People With Systemic Sclerosis NCT05234671 | Sheffield Hallam University | N/A |
| Recruiting | ILD-SARDs Registry and Biorepository NCT05007340 | McGill University Health Centre/Research Institute of the McGill University Health Centre | — |
| Unknown | Structural and Functional Impairment of Multiple Organs in Patients With Systemic Sclerosis: A MR Imaging Stud NCT05297474 | Tsinghua University | — |
| Completed | Systemic Sclerosis' Relatives Reflex NCT04917146 | Assistance Publique - Hôpitaux de Paris | — |
| Terminated | A Study to Evaluate the Safety and Tolerability of Oral Ixazomib in Scleroderma-related Lung Disease Patients NCT04837131 | Michael M. Pham | Phase 2 |
| Completed | Effect of Ozone Therapy for the Treatment of Digital Ulcer in Patients With SSc NCT04826419 | Pamukkale University | N/A |
| Unknown | Study of the Intestinal Microbiota of Patients With Systemic Sclerosis NCT04791280 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Clinical Relevance of Thoracic Echography for the Early Diagnosis of Interstitial Lung Disease in Systemic Scl NCT04725786 | University Hospital, Tours | N/A |
| Unknown | The Effects of Telerehabilitation Based Exercise Program in Patients With Systemic Sclerosis NCT05078749 | Gazi University | N/A |
| Completed | Optical Coherence Tomography Imaging in Systemic Sclerosis NCT04532151 | University Hospital, Strasbourg, France | N/A |
| Active Not Recruiting | Systemic Sclerosis and Jak Inhibitors : Emphasis on Macrophages NCT04206644 | Rennes University Hospital | — |
| Completed | A Study to Investigate Safety of GS-248 and Efficacy on Raynauds' Phenomenon in Systemic Sclerosis NCT04744207 | Gesynta Pharma AB | Phase 2 |
| Completed | Safety and Efficacy of Anaerobic Cultivated Human Intestinal Microbiome Transplantation in Systemic Sclerosis NCT04300426 | Oslo University Hospital | Phase 2 |
| Recruiting | Subcutaneous Injections of ASC to Heal Digital Ulcers in Patients With Scleroderma. NCT04356755 | University Hospital, Toulouse | Phase 2 |
| Completed | Upfront Autologous HSCT Versus Immunosuppression in Early Diffuse Cutaneous Systemic Sclerosis NCT04464434 | UMC Utrecht | Phase 4 |
| Unknown | Clinical Risk Assessment of Cognitive Function in Systemic Autoimmune Diseases NCT06029335 | University of Pecs | — |
| Completed | Utility of Breath-holding Test in Systemic Sclerosis NCT04484948 | Seoul National University Hospital | N/A |
| Recruiting | Rheumatology Patient Registry and Biorepository NCT04402086 | Yale University | — |
| Recruiting | Deployment o the Multidisciplinary Prospective Cohort Imminent NCT04334031 | University Hospital, Lille | N/A |
| Completed | The Effect of a Self-Management Program on Individuals With Scleroderma NCT06095921 | Emirhan Karakuş | N/A |
| Completed | Apollo Device for Fatigue in Systemic Sclerosis NCT04854850 | Robyn T. Domsic, MD, MPH | N/A |
| Completed | Is a History of Pre-eclampsia a Risk Factor for Vascular Phenotype in Women With Systemic Sclerosis? NCT04363021 | University Hospital, Brest | — |
| Unknown | Assessment of Nutritional Status in Systemic Sclerosis NCT04301596 | University Hospital, Montpellier | — |
| Recruiting | Cohort of Patients With Systemic Sclerosis Within the Framework of the RESO Reference Centre NCT04265144 | University Hospital, Bordeaux | N/A |
| Completed | Trial on Outpatients With Systemic Sclerosis Treated With Well-Being Therapy or With a Control Therapy NCT04212247 | University of Florence | N/A |
| Terminated | MPA AUC Monitoring in Patients Receiving MMF for Diffuse Cutaneous or Pulmonary Involvement in Systemic Sclero NCT04244916 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Online Fatigue Intervention Program for People With Scleroderma NCT04401943 | University of New Mexico | N/A |
| Completed | Effects of Fractional CO2 Laser Treatment on Vaginal Symptoms and Sexual Dysfunction in Women With Systemic Sc NCT06231433 | IRCCS San Raffaele | Phase 2 / Phase 3 |
| Completed | Evaluation of the Scleroderma Patient-centered Intervention Network COVID-19 Home-isolation Activities Togethe NCT04335279 | Lady Davis Institute | N/A |
| Unknown | Evaluating Gut Imaging and Stool Biomarkers in Patients With Scleroderma-associated Gastrointestinal Disease NCT04630782 | Singapore General Hospital | — |
| Recruiting | Subcutaneous Injection of Sodium Thiosulfate for Ectopic Calcifications or Ossifications. A Pilot Study NCT03582800 | University Hospital, Limoges | Phase 2 |
| Completed | Cold Challenge With C21 in RP NCT04388176 | Vicore Pharma AB | Phase 2 |
| Recruiting | Connective Tissue Diseases and Lung Manifestations NCT04095351 | Medical University Innsbruck | — |
| Completed | Mouth Handicap in Systemic Sclerosis NCT04273386 | Istanbul University | N/A |
| Completed | RElevance of UltraSonography for Assessing Salivary Gland Involvement in Systemic Sclerosis (SSc) NCT04001556 | Rennes University Hospital | N/A |
| Completed | The Effect of Physiotherapy Program in Scleroderma Patients NCT04179292 | Istanbul University | N/A |
| Completed | Muscular Respiratory Involvement and Systemic Sclerosis NCT04118725 | Poitiers University Hospital | N/A |
| Recruiting | Longitudinal Characterization of Microbial Signature in Systemic Sclerosis Patients NCT04132206 | Hôpital Européen Marseille | — |
| Recruiting | Belimumab and Rituximab Combination Therapy for the Treatment of Diffuse Cutaneous Systemic Sclerosis NCT03844061 | Hospital for Special Surgery, New York | Phase 2 |
| Terminated | A Clinical Study to Test Long Term Safety of GLPG1690 for Patients With Systemic Sclerosis NCT03976648 | Galapagos NV | Phase 2 |
| Completed | SPIN Self-Management Feasibility Trial NCT03914781 | Lady Davis Institute | N/A |
| Completed | Cell Surface Marker Expression in Autoimmune Diseases NCT03757065 | Alpine Immune Sciences, Inc. | — |
| Completed | IgG-4 Levels in Systemic Sclerosis NCT04219592 | Meir Medical Center | — |
| Withdrawn | Objective Measurement Methods for Autoimmune Disease and Dry Eye Syndrome NCT03937271 | Taipei Veterans General Hospital, Taiwan | — |
| Unknown | The Small Intestine Bacterial Overgrowth Study Pilot NCT03588845 | Canadian Scleroderma Research Group | N/A |
| Unknown | Periodontal Health Status in Patients with Systemic Sclerosis NCT05215431 | University of Belgrade | N/A |
| Completed | A Clinical Study to Test How Effective and Safe GLPG1690 is for Participants With Systemic Sclerosis NCT03798366 | Galapagos NV | Phase 2 |
| Completed | Effects of Fibromyalgia Syndrome in Patients With Systemic Sclerosis NCT04411498 | Antalya Training and Research Hospital | — |
| Completed | A Study to Evaluate VIB7734 in Participants With Systemic Lupus Erythematosus (SLE), Cutaneous Lupus Erythemat NCT03817424 | Amgen | Phase 1 |
| Completed | Role of Eosinophil in Fibrogenesis of Systemic Sclerosis NCT03816189 | University Hospital, Lille | — |
| Completed | Mycophenolate Mofetil Pharmacokinetics in Systemic Sclerosis NCT03678987 | Region Skane | — |
| Completed | Evaluation of Effectiveness of Acetylsalicylic Acid on Markers of Vascular Dysfunction in Scleroderma Patients NCT03558854 | Federal University of São Paulo | Phase 4 |
| Recruiting | Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis NCT03630211 | Paul Szabolcs | Phase 2 |
| Completed | Analysis of Cytokine Expression Pattern in Systemic Sclerosis NCT03537105 | Poitiers University Hospital | N/A |
| Completed | Injection of Autologous Adipose-derived Stromal Vascular Fraction in the Finger of Systemic Sclerosis Patients NCT03060551 | Suk-Ho Moon | EARLY_Phase 1 |
| Completed | Identifying Unique Pathogenic Macrophages in Systemic Sclerosis-ILD NCT03438032 | Northwestern University | — |
| Completed | Suction Based Characterization of Healthy and Diseased Skin NCT03644225 | Oliver Distler | N/A |
| Completed | Effects of a Supervised Exercise Program and a Home Exercise Program in Patients With Systemic Sclerosis NCT04675502 | Dokuz Eylul University | N/A |
| Completed | Professional and Personal Toxic Exposure in Systemic Sclerosis : Type, Intensity and Probability of Exposition NCT03543956 | University Hospital, Bordeaux | — |
| Unknown | A Pilot-Study of Sirolimus for the Treatment of Systemic Sclerosis NCT03365869 | Peking University People's Hospital | Phase 2 |
| Terminated | Cardiac Safe Transplants for Systemic Sclerosis NCT03593902 | Northwestern University | Phase 2 / Phase 3 |
| Completed | The Scleroderma Patient-centered Intervention Network (SPIN) Support Group Leader Education Program Feasibilit NCT03508661 | Lady Davis Institute | N/A |
| Completed | Rehabilitation for Arm Coordination and Hand Movement in Systemic Sclerosis NCT03482219 | University of Michigan | N/A |
| Recruiting | Meir Medical Center Rheumatologic Biobank NCT03473912 | Meir Medical Center | — |
| Completed | Description of the Functional Evolution of Diffuse Infiltrating Pneumonia Associated With Systemic Scleroderma NCT03271333 | University Hospital, Lille | — |
| Completed | Scleroderma Patient-centered Intervention Network (SPIN) Hand Program NCT03419208 | Lady Davis Institute | N/A |
| Unknown | Volatile Organic Compounds (VOCs) as a Biomarker in Immune-mediated Pulmonary Arterial Hypertension (PAH) NCT03819777 | Maastricht University Medical Center | — |
| Completed | A Systematic Review of Factors Associated With Pulmonary Arterial Hypertension in Systemic Sclerosis NCT03889509 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | — |
| Completed | Neutrophil Extracellular Traps in Systemic Sclerosis NCT03374618 | CHU de Reims | N/A |
| Completed | Yellow Fever Vaccine in Patients With Rheumatic Diseases NCT03430388 | University of Sao Paulo General Hospital | N/A |
| Recruiting | New Orleans Pulmonary Hypertension Biobank NCT03269630 | Louisiana State University Health Sciences Center in New Orleans | — |
| Completed | Prednisolone in Early Diffuse Systemic Sclerosis NCT03708718 | Prof. Ariane herrick | Phase 2 |
| Completed | Evaluation of Calcinosis in Systemic Sclerosis NCT03340194 | University Hospital, Lille | — |
| Completed | A Study of KHK4827 in Patients With Systemic Sclerosis NCT04368403 | Kyowa Kirin Co., Ltd. | Phase 1 |
| Completed | Evaluation of Tofacitinib in Early Diffuse Cutaneous Systemic Sclerosis (dcSSc) NCT03274076 | University of Michigan | Phase 1 / Phase 2 |
| Unknown | Pulmonary Hypertension Screening for Rheumatology Patients (SOPHIE) NCT03446339 | The University of Hong Kong | — |
| Unknown | Autologous Adipose Tissue in the Treatment of Systemic Sclerosis Digital Ulcers NCT03406988 | ASST Gaetano Pini-CTO | N/A |
| Completed | Scleroderma Patient-centered Intervention Network (SPIN) Hand Program Feasibility Study NCT03092024 | Lady Davis Institute | N/A |
| Withdrawn | Intraoperative ICG for Systemic Sclerosis NCT03155464 | Duke University | Phase 4 |
| Unknown | Pirfenidone as Treatment of Skin Fibrosis in Systemic Sclerosis NCT03068234 | RenJi Hospital | Phase 2 / Phase 3 |
| Unknown | Echo Systemic Sclerosis NCT03143413 | University Hospital, Clermont-Ferrand | — |
| Completed | The Effect of a Home-based Orofacial Exercise Program on Oral Aperture of Systemic Sclerosis Patients NCT04336475 | Cukurova University | N/A |
| Completed | Individualized Home-based Exercise Program for Patient With Systemic Sclerosis. NCT03614208 | Universita di Verona | N/A |
| Unknown | SCLERoderma et Adipose-DErived Stroma Cells NCT02866552 | Assistance Publique Hopitaux De Marseille | Phase 2 |
| Unknown | The Effect of High Dose Methylprednisolone on Nailfold in Early Systemic Sclerosis ( SSc ) NCT03059979 | Radboud University Medical Center | EARLY_Phase 1 |
| Completed | Effectiveness and Safety of SAR156597 in Treating Diffuse Systemic Sclerosis NCT02921971 | Sanofi | Phase 2 |
| Completed | Evaluation of Aesthetic Impact in Patients With Systemic Sclerosis NCT03271320 | University Hospital, Lille | — |
| Terminated | Dimethyl Fumarate (DMF) in Systemic Sclerosis-Associated Pulmonary Arterial Hypertension NCT02981082 | Robert Lafyatis | Phase 1 |
| Completed | ADMSCs for the Treatment of Systemic Sclerosis NCT02975960 | The Catholic University of Korea | N/A |
| Completed | Study to Compare the Efficacy of Mycophenolate Mofetil in Systemic Sclerosis Related Early Interstitial Lung D NCT02896205 | Post Graduate Institute of Medical Education and Research, Chandigarh | Phase 3 |
| Completed | Safety and Efficacy of Oral Treprostinil in the Treatment of Calcinosis in Patients With Systemic Sclerosis NCT02663895 | Stanford University | Phase 2 |
| Completed | Effectiveness of a Home-based, Self-administered Exercise Program for Hands in Patients With Systemic Sclerosi NCT04481984 | Cukurova University | N/A |
| Completed | The Effects of Exercise in Patients With Systemic Sclerosis NCT03058887 | Sheffield Hallam University | N/A |
| Unknown | FOLLOW HEART TRANSPLANT FOR ACHIEVING THE HEART PRIMITIVE RELATED SCLERODERMA SYSTEMIC NCT02808481 | University Hospital, Strasbourg, France | — |
| Terminated | Duke Scleroderma Clinic Patient Registry NCT02851875 | Duke University | — |
| Completed | Comparing and Combining Bortezomib and Mycophenolate in SSc Pulmonary Fibrosis NCT02370693 | Northwestern University | Phase 2 |
| Unknown | Seoul National University Hospital Systemic Sclerosis Cohort NCT02819947 | Seoul National University Hospital | — |
| Completed | Itch and Clinacal Caracteristics in Systemic Sclerosis NCT03297580 | University Hospital, Brest | — |
| Withdrawn | Systemic Sclerosis Clinical and Biomarker Study NCT02531009 | Biogen | — |
| Completed | A Study of the Efficacy and Safety of Tocilizumab in Participants With Systemic Sclerosis (SSc) NCT02453256 | Hoffmann-La Roche | Phase 3 |
| Completed | Topical Rosemary Oil Application in Systemic Sclerosis NCT03531216 | ARCIM Institute Academic Research in Complementary and Integrative Medicine | N/A |
| Unknown | CSL Behring Sclero XIII NCT02551042 | University College, London | Phase 2 |
| Completed | Safety Of Fat Micrografts With Adipose-Derived Stromal Vascular Fraction In Hands Of Patients With Systemic Sc NCT04387825 | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | Phase 2 |
| Completed | Effectiveness of Saccharomyces Boulardii for Gastrointestinal Bacterial-overgrowth in Systemic Sclerosis NCT03692299 | Coordinación de Investigación en Salud, Mexico | Phase 4 |
| Completed | Scleroderma Treatment With Celution Processed Adipose Derived Regenerative Cells (STAR) NCT02396238 | Cytori Therapeutics | N/A |
| Withdrawn | Evaluating Pulmonary Arterial Hypertension in Patients With Systemic Sclerosis NCT02339961 | Echosense Ltd. | N/A |
| Terminated | Treatment of Digital Ulcers in Korean Patients With Systemic Sclerosis: a Prospective Cohort Study NCT02642146 | Seoul National University Hospital | — |
| Completed | Long Term Effect of Buspirone on Esophageal Function and Esophageal Symptoms in Patients With Systematic Scler NCT02363478 | Laikο General Hospital, Athens | EARLY_Phase 1 |
| Unknown | Effects of Probiotics on Gastrointestinal Symptoms and on the Immune System in Patients With Systemic Sclerosi NCT02302352 | Federal University of São Paulo | Phase 3 |
| Completed | Endothelial Microparticles in Systemic Sclerosis Pulmonary Hypertension NCT02331225 | Louisiana State University Health Sciences Center in New Orleans | — |
| Unknown | Vocal Intervention in Systemic Sclerosis NCT02821663 | Medical University of Vienna | N/A |
| Withdrawn | Evaluation of Pulmonary Doppler Signals in Patients With Systemic Sclerosis(SSc) NCT02278445 | Echosense Ltd. | N/A |
| Terminated | Evaluating Lung Doppler Signals in Patients With Systemic Sclerosis (SSc) NCT02246348 | Echosense Ltd. | N/A |
| Terminated | Detecting Pulmonary Arterial Hypertension (PAH) in Patients With Systemic Sclerosis (SSc) by Ultrasound NCT02243111 | Echosense Ltd. | N/A |
| Completed | Analysis of the Distribution of Regulatory B Cells in Blood of Multiple Sclerosis Patients NCT02789670 | University Hospital, Lille | — |
| Unknown | EFFECTS OF THE MICRO REINJECTION OF AUTOLOGOUS ADIPOSE TISSUE IN THE FACE OF PATIENTS WITH SYSTEMIC SCLEROSIS NCT02206672 | Assistance Publique Hopitaux De Marseille | N/A |
| Completed | Early Treatment of Borderline Pulmonary Arterial Hypertension Associated With Systemic Sclerosis (SSc-APAH) NCT02290613 | Heidelberg University | Phase 2 |
| Withdrawn | Divalproex Sodium in the Treatment of the Cutaneous Manifestations of Scleroderma NCT02166229 | Yale University | Phase 1 / Phase 2 |
| Completed | Soluble VE-cadherin and VE-cadherin Antibody in Sclerodermic Sclerosis NCT02212249 | University Hospital, Grenoble | N/A |
| Completed | Swallowing Difficulties With Medication Intake and Coping Strategies in Patients With Systemic Sclerosis NCT02105818 | Kurt Hersberger | — |
| Unknown | The Role of Gastroesophageal Reflux in Scleroderma Pulmonary Fibrosis NCT02136394 | Royal Brompton & Harefield NHS Foundation Trust | — |
| Completed | Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases NCT01988506 | Assistance Publique - Hôpitaux de Paris | Phase 2 |
| Unknown | Lysyl Oxidase, Semaphorin 7a and Semaphorin 3a in Patients With Systemic Sclerosis NCT01943968 | Hillel Yaffe Medical Center | N/A |
| Completed | Safety and Tolerability of Pirfenidone in Participants With Systemic Sclerosis-Related Interstitial Lung Disea NCT01933334 | Genentech, Inc. | Phase 2 |
| Completed | Lower Urinary Tract Symptoms in Systemic Sclerosis NCT01971294 | University Hospital, Geneva | — |
| Completed | Gastroesophageal Reflux Treatment in Scleroderma NCT01878526 | Khon Kaen University | Phase 3 |
| Completed | Prevalence and Predictors of Proton Pump Inhibitor Partial Response in Gastroesophageal Reflux Disease in Syst NCT03561233 | Khon Kaen University | Phase 1 |
| Unknown | Treatment and Prevention of Progression of Interstitial Lung Disease in Systemic Sclerosis NCT01858259 | Gabriela Riemekasten | — |
| Unknown | Clinical Trial of Probiotics in Systemic Sclerosis Associated Gastrointestinal Disease NCT01804959 | Singapore General Hospital | Phase 2 |
| Completed | Rituximab in Systemic Sclerosis NCT01748084 | Assistance Publique - Hôpitaux de Paris | Phase 2 / Phase 3 |
| Unknown | Development and Prevention of Severe Heart Disease in Systemic Sclerosis NCT01829126 | Gabriele Valentini | — |
| Unknown | IVIG Treatment in Systemic Sclerosis NCT01785056 | Georgetown University | N/A |
| Unknown | Development and Prevention of Pulmonary Hypertension in Systemic Sclerosis NCT01840748 | University of Paris 5 - Rene Descartes | — |
| Unknown | Improvement of Hand Dysfunction by Arthritis in Systemic Sclerosis NCT01834157 | Prof. Laszlo Czirjak | — |
| Unknown | Prevention and Treatment of Digital Ulcers in Systemic Sclerosis NCT01836263 | marco matucci cerinic | — |
| Completed | Cyclophosphamide Systemic Sclerosis Associated Interstitial Lung Disease NCT01570764 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Completed | Proof of Biological Activity of SAR100842 in Systemic Sclerosis NCT01651143 | Sanofi | Phase 2 |
| Completed | Assessment of the Subcutaneous Reinjection of Human Autologous Adipose-derived Stromal Vascular Fraction (Celu NCT01813279 | Assistance Publique Hopitaux De Marseille | N/A |
| Completed | Conception of an ICF Core Set for Systemic Sclerosis NCT01848418 | Assistance Publique - Hôpitaux de Paris | — |
| Terminated | Study of Pomalidomide (CC-4047) to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Effec NCT01559129 | Celgene | Phase 2 |
| Completed | Belimumab for the Treatment of Diffuse Cutaneous Systemic Sclerosis NCT01670565 | Hospital for Special Surgery, New York | Phase 2 |
| Completed | Vasculopathy, Inflammation and Systemic Sclerosis NCT02562079 | University Hospital, Bordeaux | N/A |
| Completed | Sacroiliitis in Systemic Sclerosis NCT01673633 | Cukurova University | — |
| Completed | IL1-TRAP, Rilonacept, in Systemic Sclerosis NCT01538719 | Boston University | Phase 1 / Phase 2 |
| Completed | An Open-Label Study to Evaluate Biomarkers and Safety in Systemic Sclerosis Patients Treated With ABR-215757 ( NCT01487551 | Active Biotech AB | Phase 2 |
| Completed | Macitentan for the Treatment of Digital Ulcers in Systemic Sclerosis Patients NCT01474109 | Actelion | Phase 3 |
| Completed | Hemodynamic Changes in Connective Tissue Disease NCT01468792 | Medical University of Graz | — |
| Completed | Bosentan in Systemic Sclerosis NCT01395732 | Actelion | Phase 4 |
| Completed | Neuropsychiatric Scleroderma Study: Systematic Evaluation of Neuropsychiatric Involvement in Systemic Sclerosi NCT01488214 | University Hospital, Lille | N/A |
| Completed | Digital Ulceration NCT01377090 | Actelion | — |
| Completed | Sonographic and Laboratory Evaluation of the Thyroid Gland in Patients With Systemic Sclerosis NCT01270425 | Meir Medical Center | — |
| Completed | Nilotinib in the Treatment of Systemic Sclerosis NCT01166139 | Hospital for Special Surgery, New York | Phase 2 |
| Completed | Auto-immunity and Pulmonary Arterial Hypertension NCT01208792 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Study of Ambrisentan With Antifibrotic Agent Combination Therapy in Diffuse Systemic Sclerosis NCT01093885 | University of Pennsylvania | N/A |
| Completed | A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Scle NCT01042158 | Johns Hopkins University | Phase 4 |
| Completed | Effects of Intensive Aerobic and Muscle Endurance Exercise in Patients With Systemic Sclerosis - a Pilot Study NCT01813578 | Karolinska University Hospital | N/A |
| Terminated | Open-Label Study of Oral Treprostinil in Digital Ulcers NCT00848107 | United Therapeutics | Phase 2 |
| Unknown | Allogeneic Mesenchymal Stem Cells Transplantation for Systemic Sclerosis (SSc) NCT00962923 | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | Phase 1 / Phase 2 |
| Completed | Small Intestinal Mucosal Abnormalities in Systemic Sclerosis Using Capsule Endoscopy NCT00958672 | University Hospital, Rouen | — |
| Completed | The CARRA Registry NCT01697254 | Duke University | — |
| Completed | Digital Ischemic Lesions in Scleroderma Treated With Oral Treprostinil Diethanolamine NCT00775463 | United Therapeutics | Phase 2 |
| Completed | Exercise Induced Pulmonary Hypertension in Systemic Sclerosis and Treatment With Ambrisentan NCT01051960 | University of California, Los Angeles | Phase 4 |
| Unknown | Low-Dose Oral Imatinib for Scleroderma Pulmonary Involvement NCT00573326 | Azienda Ospedaliera Universitaria Policlinico | Phase 2 |
| Completed | Pharmacokinetics of Oral Treprostinil in Patients With Systemic Sclerosis NCT00848939 | United Therapeutics | Phase 1 |
| Unknown | AIMSPRO in Established Diffuse Cutaneous Systemic Sclerosis NCT00769028 | Daval International Limited | Phase 2 |
| Completed | Skin Biopsy Specimens as Biomarkers of Systemic Sclerosis and Response to Mycophenolate Mofetil NCT00853788 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | — |
| Terminated | Early, Simple and Reliable Detection of Pulmonary Arterial Hypertension (PAH) in Systemic Sclerosis (SSc) NCT00706082 | Actelion | — |
| Completed | Effect of Rosuvastatin on Systemic Sclerosis-related Pulmonary Hypertension NCT00984932 | University of Alexandria | Phase 3 |
| Completed | Stimulatory Autoantibodies to the Platelet-Derived Growth Factor Receptor (PDGFR) in Patients With Systemic Sc NCT00667134 | University of Michigan | — |
| Terminated | Effectiveness of UVA1-irradiation in the Treatment of Early Skin Fibrosis in Patients Suffering From Systemic NCT00628797 | Nicolas Hunzelmann | Phase 1 / Phase 2 |
| Completed | Early Therapy of Pulmonary Arterial Hypertension NCT00909337 | Medical University of Graz | N/A |
| Completed | Investigation of Coronary and Pulmonary Circulatory Parameters in Systemic Sclerosis NCT00843102 | University of Pecs | — |
| Unknown | Pulmonary Arterial Hypertension in Systemic Sclerosis NCT00617487 | Fondazione IRCCS Policlinico San Matteo di Pavia | — |
| Completed | Oral Health and People With Systemic Sclerosis NCT01817361 | University of Alabama at Birmingham | — |
| Completed | A Study Using The Experimental Drug Called Imatinib (Gleevec) in Subjects With Systemic Sclerosis NCT00512902 | University of California, Los Angeles | Phase 1 / Phase 2 |
| Terminated | Reduced Intensity Transplant in Medically Refractory Systemic Lupus Erythematosus (SLE) and Systemic Sclerosis NCT00684255 | New York Medical College | Phase 1 |
| Completed | Imatinib Mesylate (Gleevec) in the Treatment of Systemic Sclerosis NCT00555581 | Hospital for Special Surgery, New York | Phase 2 |
| Completed | Angiogenic/Angiostatic Mediators in Patients With Systemic Sclerosis NCT00668473 | University of Michigan | — |
| Unknown | Non-Invasive Diagnostic and Functional Evaluation of Cardiac Involvement in Patients With Systemic Sclerosis NCT00453752 | Medical University of Warsaw | — |
| Completed | Multi-center, Web Based Observational Study of Pulmonary Hypertension in Scleroderma Patients NCT00377949 | Georgetown University | — |
| Completed | The Effect of Physical Therapy on Raynaud's Phenomenon Secondary to Systemic Sclerosis NCT00946738 | Charite University, Berlin, Germany | N/A |
| Completed | Efficacy and Safety of Oral Bosentan on Healing/Prevention of Digital (Finger) Ulcers in Patients With Sclerod NCT00077584 | Actelion | Phase 3 |
| Terminated | Nonmyeloablative Allo Stem Cell Transplant for Severe Autoimmune Diseases NCT00849745 | Duke University | Phase 1 |
| Completed | Rapamycin vs Methotrexate in Diffuse SSc NCT00241189 | University of California, Los Angeles | Phase 1 / Phase 2 |
| Terminated | Safety and Value of Self Bone Marrow Transplants Following Chemotherapy in Scleroderma Patients NCT00040651 | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | Phase 1 |
| Completed | Small Bowel Motor Impairment in Scleroderma: Results of a Prospective 5-year Manometric Follow-up NCT00213460 | University Hospital, Rouen | — |
| Completed | Trial of IC351 in Female Scleroderma Patients With Raynaud's and Sexual Dysfunction NCT00707187 | University of Medicine and Dentistry of New Jersey | Phase 2 |
| Completed | Psychological Treatments for Scleroderma NCT00007267 | Johns Hopkins University | Phase 2 |
| Completed | Pilot Study of Total Body Irradiation in Combination With Cyclophosphamide, Anti-thymocyte Globulin, and Autol NCT00010335 | Fred Hutchinson Cancer Center | Phase 1 |
| Completed | Scleroderma Registry NCT00074568 | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | — |
| Completed | Phase II Pilot Study of Cyclophosphamide and Rabbit Anti-Thymocyte Globulin as Salvage Therapy in Patients Wit NCT00016458 | Fred Hutchinson Cancer Center | Phase 2 |
| Completed | Stem Cell Transplant to Treat Patients With Systemic Sclerosis NCT00058578 | Baylor College of Medicine | Phase 1 |
| Completed | Recombinant Human Relaxin in the Treatment of Diffuse Scleroderma NCT00704665 | University of Medicine and Dentistry of New Jersey | Phase 3 |
| Unknown | Genetic Study of the FBN1 Gene and Fibrillin-1 Abnormalities in Choctaw Native Americans and Other Patients Wi NCT00006393 | National Center for Research Resources (NCRR) | — |
| Terminated | Effect of Different Iloprost Doses on Symptoms in Systemic Sclerosis NCT00622687 | Charite University, Berlin, Germany | Phase 2 |
| Completed | Phase III Randomized, Double-Blind, Placebo-Controlled Study of Oral Iloprost for Raynaud's Phenomenon Seconda NCT00004786 | National Center for Research Resources (NCRR) | Phase 3 |
| Completed | Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity NCT03941184 | Mayo Clinic | — |